STRINGSTRING
MED28 MED28 METTL14 METTL14 MED21 MED21 ENSUMAP00000005096 ENSUMAP00000005096 PHF19 PHF19 MED15 MED15 EIF4E EIF4E PIWIL2 PIWIL2 PELO PELO FGF10 FGF10 MED17 MED17 ENSUMAP00000009652 ENSUMAP00000009652 NODAL NODAL REST REST JAG1 JAG1 DLL1 DLL1 FANCC FANCC ENSUMAP00000011864 ENSUMAP00000011864 LSM1 LSM1 YAP1 YAP1 TBX3 TBX3 MTF2 MTF2 SRRT SRRT NIPBL NIPBL RTF1 RTF1 LRP5 LRP5 BMPR1A BMPR1A BRAF BRAF CTR9 CTR9 WNT9B WNT9B IGF2BP1 IGF2BP1 DIS3L2 DIS3L2 EIF4ENIF1 EIF4ENIF1 MED27 MED27 LIF LIF RAF1 RAF1 MED14 MED14 ENSUMAP00000024222 ENSUMAP00000024222 PROX1 PROX1 PRDM14 PRDM14 FANCD2 FANCD2 SMC1A SMC1A LEO1 LEO1 PAF1 PAF1 HESX1 HESX1 KLF10 KLF10 FOXO3 FOXO3 NR2E1 NR2E1 MED30 MED30 GNL3 GNL3 PCM1 PCM1 CUL4A CUL4A PADI4 PADI4 SETD6 SETD6 PADI1 PADI1 SS18 SS18 FAXC FAXC FZD7 FZD7 SMC5 SMC5 ZHX2 ZHX2 MED12 MED12 LDB1 LDB1 TRIM8 TRIM8 SMC3 SMC3 SALL4 SALL4 STAT3 STAT3 HOOK3 HOOK3 SFRP1 SFRP1 HES1 HES1 BCL9L BCL9L DDX6 DDX6 RIF1 RIF1 VPS72 VPS72 MED7 MED7 NANOG NANOG LDB2 LDB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MED28Mediator of RNA polymerase II transcription subunit 28. (175 aa)
METTL14N6-adenosine-methyltransferase subunit METTL14; Belongs to the MT-A70-like family. (456 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (144 aa)
ENSUMAP00000005096annotation not available (174 aa)
PHF19PHD finger protein 19. (472 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (597 aa)
EIF4EEukaryotic Translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (970 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (616 aa)
ENSUMAP00000009652annotation not available (108 aa)
NODALNodal homolog. (271 aa)
RESTRE1-silencing transcription factor. (1213 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (695 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (590 aa)
ENSUMAP00000011864annotation not available (106 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
YAP1LOW QUALITY PROTEIN: yorkie homolog. (457 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (130 aa)
MTF2Metal-response element-binding transcription factor 2 isoform X1. (593 aa)
SRRTSerrate RNA effector molecule homolog isoform X1. (876 aa)
NIPBLNipped-B protein. (2805 aa)
RTF1RNA polymerase-associated protein RTF1 homolog. (656 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1602 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BRAFSerine/threonine-protein kinase B-raf. (715 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
IGF2BP1Insulin-like growth factor 2 mRNA-binding protein 1 isoform X1. (577 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (926 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (985 aa)
MED27Mediator of RNA polymerase II transcription subunit 27. (311 aa)
LIFLeukemia inhibitory factor. (204 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1338 aa)
ENSUMAP00000024222annotation not available (52 aa)
PROX1Prospero homeobox protein 1. (737 aa)
PRDM14PR domain zinc finger protein 14. (566 aa)
FANCD2Fanconi anemia group D2 protein. (1453 aa)
SMC1AStructural maintenance of chromosomes protein. (1234 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (665 aa)
PAF1RNA polymerase II-associated factor 1 homolog. (479 aa)
HESX1Homeobox expressed in ES cells 1. (181 aa)
KLF10Krueppel-like factor 10. (480 aa)
FOXO3Forkhead box protein O3. (453 aa)
NR2E1LOW QUALITY PROTEIN: nuclear receptor subfamily 2 group E member 1. (372 aa)
MED30Mediator of RNA polymerase II transcription subunit 30. (178 aa)
GNL3Guanine nucleotide-binding protein-like 3. (550 aa)
PCM1Pericentriolar material 1 protein. (2187 aa)
CUL4Acullin-4A; Belongs to the cullin family. (856 aa)
PADI4Protein-arginine deiminase type-4 isoform X1. (665 aa)
SETD6N-lysine methyltransferase SETD6. (383 aa)
PADI1Protein-arginine deiminase type-1. (651 aa)
SS18Protein SSXT. (395 aa)
FAXCFailed axon connections homolog, metaxin like GST domain containing. (409 aa)
FZD7LOW QUALITY PROTEIN: frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (541 aa)
SMC5LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 5. (1049 aa)
ZHX2Zinc fingers and homeoboxes protein 2. (840 aa)
MED12LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 12. (2045 aa)
LDB1LIM domain-binding protein 1 isoform X1. (375 aa)
TRIM8Probable E3 ubiquitin-protein ligase TRIM8. (515 aa)
SMC3Structural maintenance of chromosomes protein. (1103 aa)
SALL4Sal-like protein 4. (1021 aa)
STAT3Signal transducer and activator of transcription. (838 aa)
HOOK3Protein Hook homolog 3. (678 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
HES1Transcription factor HES-1. (166 aa)
BCL9LLOW QUALITY PROTEIN: B-cell CLL/lymphoma 9-like protein. (1497 aa)
DDX6Probable ATP-dependent RNA helicase DDX6; Belongs to the DEAD box helicase family. (483 aa)
RIF1Replication timing regulatory factor 1. (2473 aa)
VPS72Vacuolar protein sorting-associated protein 72 homolog. (364 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (232 aa)
NANOGHomeobox protein NANOG isoform X1. (315 aa)
LDB2LIM domain-binding protein 2 isoform X1. (373 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.