STRINGSTRING
THOC5 THOC5 CSF1 CSF1 SP3 SP3 FASN FASN MED1 MED1 MYH9 MYH9 PDE1B PDE1B IL31RA IL31RA CSF2 CSF2 GPR68 GPR68 VEGFA VEGFA PIR PIR BMP4 BMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THOC5THO complex subunit 5 homolog isoform X1. (694 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
SP3Transcription factor Sp3. (727 aa)
FASNFatty acid synthase. (2457 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
MYH9LOW QUALITY PROTEIN: myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2048 aa)
PDE1BPhosphodiesterase. (524 aa)
IL31RAInterleukin-31 receptor subunit alpha. (730 aa)
CSF2Granulocyte-macrophage colony-stimulating factor isoform X1. (277 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (211 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (179 aa)
PIRPirin isoform X1; Belongs to the pirin family. (331 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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