STRINGSTRING
PTPRJ PTPRJ NEXMIF NEXMIF EMILIN1 EMILIN1 MEOX2 MEOX2 MIIP MIIP PODN PODN TRIB1 TRIB1 JUP JUP DUSP10 DUSP10 FAM102A FAM102A PIP5KL1 PIP5KL1 DAG1 DAG1 ABHD6 ABHD6 ENSUMAP00000032426 ENSUMAP00000032426 PTPRG PTPRG THY1 THY1 STARD13 STARD13 MITF MITF ARID2 ARID2 TIE1 TIE1 SVBP SVBP CLDN19 CLDN19 GPR18 GPR18 LDLRAD4 LDLRAD4 STAT3 STAT3 ANGPT2 ANGPT2 STK24 STK24 ZMYND8 ZMYND8 RAP2A RAP2A ADA ADA SFRP1 SFRP1 DACH1 DACH1 PTPRU PTPRU TBX5 TBX5 PRKG1 PRKG1 ENSUMAP00000015139 ENSUMAP00000015139 RECK RECK DNAJA4 DNAJA4 LOC103668179 LOC103668179 TCAF1 TCAF1 TCAF2 TCAF2 EPHA1 EPHA1 RAP2B RAP2B STK26 STK26 RAP2C RAP2C ENSUMAP00000016356 ENSUMAP00000016356 PFN2 PFN2 PTEN PTEN DLL4 DLL4 FAM102B FAM102B MEOX1 MEOX1 CORO1B CORO1B RNF20 RNF20 CLIC4 CLIC4 HDAC5 HDAC5 STAP1 STAP1 DLG5 DLG5 ENSUMAP00000018906 ENSUMAP00000018906 ADORA3 ADORA3 LY6G5B LY6G5B CSNK2B CSNK2B NRG3 NRG3 BMPR1A BMPR1A MMRN2 MMRN2 THBS1 THBS1 LOC103671894 LOC103671894 SPRED1 SPRED1 BRAF BRAF NF1 NF1 ENSUMAP00000020575 ENSUMAP00000020575 AIF1 AIF1 TNF TNF RABGEF1 RABGEF1 GDF2 GDF2 CARD10 CARD10 PATZ1 PATZ1 KLRK1 KLRK1 SFRP2 SFRP2 TP53INP1 TP53INP1 RNF41 RNF41 ATP1B2 ATP1B2 MCC MCC LRCH1 LRCH1 HMGB1 HMGB1 ADTRP ADTRP NEDD9 NEDD9 EPHA4 EPHA4 SULF1 SULF1 PTPRM PTPRM COL3A1 COL3A1 KRIT1 KRIT1 SRGAP3 SRGAP3 KANK1 KANK1 EMILIN2 EMILIN2 ADAM15 ADAM15 FOXO3 FOXO3 IGFBP5 IGFBP5 RIPOR2 RIPOR2 SRGAP1 SRGAP1 SLURP1 SLURP1 DLC1-2 DLC1-2 TMEFF2 TMEFF2 CCN3 CCN3 MECP2 MECP2 PTPRR PTPRR APOH APOH BMP10 BMP10 NDRG4 NDRG4 NISCH NISCH OSBPL8 OSBPL8 PADI2 PADI2 NAV3 NAV3 ADGRG1 ADGRG1 TNFAIP6 TNFAIP6 ENG ENG ENSUMAP00000000372 ENSUMAP00000000372 EVL EVL PTPRK PTPRK ENSUMAP00000001219 ENSUMAP00000001219 BCR BCR GJA1 GJA1 PTPRT PTPRT DCN DCN WDR63 WDR63 RRAS RRAS SINHCAF SINHCAF SCAI SCAI ARHGDIB ARHGDIB PDCD10 PDCD10 APOD APOD SLIT2 SLIT2 DAB2IP DAB2IP ITGB1BP1 ITGB1BP1 PTPN23 PTPN23 CD74 CD74 SRGAP2 SRGAP2 C5 C5 ADIPOQ ADIPOQ HRG HRG IL27RA IL27RA FGF2 FGF2 BMERB1 BMERB1 CX3CR1 CX3CR1 GCSAM GCSAM RIN3 RIN3 FLCN FLCN MEF2C MEF2C ADIPOR1 ADIPOR1 ATP2B4 ATP2B4 CNN2 CNN2 WASL WASL ACVR1C ACVR1C LOC103677394 LOC103677394 CORO1C CORO1C ABHD2 ABHD2 CCL21 CCL21 GADD45A GADD45A FUZ FUZ VASH1 VASH1 PTGER4 PTGER4 CXCL13 CXCL13 NODAL NODAL ARPIN ARPIN DPYSL3 DPYSL3 SEMA6D SEMA6D SYNJ2BP SYNJ2BP IGFBP3 IGFBP3 CD300A CD300A ENSUMAP00000010835 ENSUMAP00000010835 JAG1 JAG1 ACVRL1 ACVRL1 DPEP1 DPEP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPRJReceptor-type tyrosine-protein phosphatase eta isoform X1. (1203 aa)
NEXMIFProtein KIAA2022 homolog. (1501 aa)
EMILIN1EMILIN-1. (542 aa)
MEOX2Homeobox protein MOX-2. (303 aa)
MIIPMigration and invasion-inhibitory protein. (401 aa)
PODNPodocan. (614 aa)
TRIB1Tribbles homolog 1. (191 aa)
JUPJunction plakoglobin. (716 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
FAM102AFamily with sequence similarity 102 member A. (379 aa)
PIP5KL1Phosphatidylinositol 4-phosphate 5-kinase-like protein 1. (382 aa)
DAG1Dystroglycan 1. (888 aa)
ABHD6Monoacylglycerol lipase ABHD6 isoform X1. (337 aa)
ENSUMAP00000032426annotation not available (94 aa)
PTPRGLOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase gamma. (1315 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
STARD13StAR related lipid transfer domain containing 13. (1107 aa)
MITFMicrophthalmia-associated transcription factor isoform X2. (524 aa)
ARID2LOW QUALITY PROTEIN: AT-rich interactive domain-containing protein 2. (1411 aa)
TIE1Tyrosine-protein kinase receptor Tie-1. (907 aa)
SVBPCoiled-coil domain-containing protein 23. (66 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
GPR18N-arachidonyl glycine receptor; Belongs to the G-protein coupled receptor 1 family. (331 aa)
LDLRAD4Low-density lipoprotein receptor class A domain-containing protein 4. (289 aa)
STAT3Signal transducer and activator of transcription. (838 aa)
ANGPT2Angiopoietin-2 isoform X2. (494 aa)
STK24Serine/threonine-protein kinase 24 isoform X1. (445 aa)
ZMYND8Protein kinase C-binding protein 1. (1210 aa)
RAP2ARAP2A, member of RAS oncogene family. (183 aa)
ADAAdenosine deaminase isoform X4. (423 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
DACH1LOW QUALITY PROTEIN: dachshund homolog 1. (583 aa)
PTPRULOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase U. (1424 aa)
TBX5T-box transcription factor TBX5. (474 aa)
PRKG1cGMP-dependent protein kinase 1. (472 aa)
ENSUMAP00000015139annotation not available (194 aa)
RECKReversion-inducing cysteine-rich protein with Kazal motifs. (926 aa)
DNAJA4dnaJ homolog subfamily A member 4. (408 aa)
LOC103668179LOW QUALITY PROTEIN: high mobility group protein B1-like. (200 aa)
TCAF1Protein FAM115A isoform X1. (919 aa)
TCAF2Protein FAM115C. (904 aa)
EPHA1Ephrin type-A receptor 1. (942 aa)
RAP2BRAP2B, member of RAS oncogene family. (183 aa)
STK26Serine/threonine-protein kinase MST4. (416 aa)
RAP2CRas-related protein Rap-2c isoform X2. (117 aa)
ENSUMAP00000016356annotation not available (93 aa)
PFN2Profilin; Belongs to the profilin family. (98 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
FAM102BProtein FAM102B. (329 aa)
MEOX1Homeobox protein MOX-1 isoform X1. (254 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (408 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (252 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (679 aa)
STAP1Signal-transducing adaptor protein 1 isoform X1. (293 aa)
DLG5Disks large homolog 5; Belongs to the MAGUK family. (1852 aa)
ENSUMAP00000018906annotation not available (223 aa)
ADORA3Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (318 aa)
LY6G5BLymphocyte antigen 6 complex locus protein G5b. (217 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (250 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform. (341 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MMRN2Multimerin 2. (877 aa)
THBS1LOW QUALITY PROTEIN: thrombospondin-1. (1168 aa)
LOC103671894Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (172 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1. (445 aa)
BRAFSerine/threonine-protein kinase B-raf. (715 aa)
NF1Neurofibromin. (2862 aa)
ENSUMAP00000020575annotation not available (177 aa)
AIF1Leukocyte-specific transcript 1 protein. (191 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
RABGEF1Rab5 GDP/GTP exchange factor isoform X2. (491 aa)
GDF2Growth/differentiation factor 2. (402 aa)
CARD10Caspase recruitment domain-containing protein 10. (852 aa)
PATZ1POZ-, AT hook-, and zinc finger-containing protein 1. (536 aa)
KLRK1NKG2-D type II integral membrane protein isoform X1. (180 aa)
SFRP2Secreted frizzled-related protein 2. (299 aa)
TP53INP1Tumor protein p53-inducible nuclear protein 1 isoform X1. (239 aa)
RNF41E3 ubiquitin-protein ligase NRDP1. (317 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (237 aa)
MCCColorectal mutant cancer protein. (998 aa)
LRCH1Leucine-rich repeat and calponin homology domain-containing protein 1. (650 aa)
HMGB1High mobility group protein B1. (215 aa)
ADTRPAndrogen-dependent TFPI-regulating protein. (246 aa)
NEDD9Enhancer of filamentation 1. (842 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (911 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (886 aa)
PTPRMReceptor-type tyrosine-protein phosphatase mu. (1390 aa)
COL3A1Collagen alpha-1(III) chain. (762 aa)
KRIT1Krev interaction trapped protein 1. (736 aa)
SRGAP3SLIT-ROBO Rho GTPase-activating protein 3. (333 aa)
KANK1LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 1. (1289 aa)
EMILIN2EMILIN-2. (1030 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15. (772 aa)
FOXO3Forkhead box protein O3. (453 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (271 aa)
RIPOR2Protein FAM65B. (974 aa)
SRGAP1SLIT-ROBO Rho GTPase-activating protein 1. (1074 aa)
SLURP1Secreted LY6/PLAUR domain containing 1. (130 aa)
DLC1-2Rho GTPase-activating protein 7 isoform X5. (361 aa)
TMEFF2Tomoregulin-2. (317 aa)
CCN3Protein NOV homolog. (220 aa)
MECP2methyl-CpG-binding protein 2. (172 aa)
PTPRRReceptor-type tyrosine-protein phosphatase R isoform X1. (652 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
NDRG4Protein NDRG4 isoform X1. (356 aa)
NISCHLOW QUALITY PROTEIN: nischarin. (595 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (873 aa)
PADI2Protein-arginine deiminase type-2. (700 aa)
NAV3Neuron navigator 3 isoform X1. (2386 aa)
ADGRG1LOW QUALITY PROTEIN: G-protein coupled receptor 56; Belongs to the G-protein coupled receptor 2 family. (660 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein. (277 aa)
ENGEndoglin. (609 aa)
ENSUMAP00000000372annotation not available (53 aa)
EVLena/VASP-like protein. (160 aa)
PTPRKReceptor-type tyrosine-protein phosphatase kappa. (1368 aa)
ENSUMAP00000001219annotation not available (80 aa)
BCRBCR activator of RhoGEF and GTPase. (1162 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
PTPRTReceptor-type tyrosine-protein phosphatase T. (1453 aa)
DCNDecorin; May affect the rate of fibrils formation. (355 aa)
WDR63WD repeat-containing protein 63 isoform X1. (900 aa)
RRASRas-related protein R-Ras. (195 aa)
SINHCAFSIN3-HDAC complex associated factor. (221 aa)
SCAIProtein SCAI; Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. (578 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (200 aa)
PDCD10Programmed cell death protein 10. (212 aa)
APODApolipoprotein D. (183 aa)
SLIT2Slit homolog 2 protein isoform X1. (1530 aa)
DAB2IPDisabled homolog 2-interacting protein. (877 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
PTPN23LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 23. (1171 aa)
CD74LOW QUALITY PROTEIN: HLA class II histocompatibility antigen gamma chain. (279 aa)
SRGAP2SLIT-ROBO Rho GTPase-activating protein 2 isoform X3. (1071 aa)
C5Complement C5. (1676 aa)
ADIPOQAdiponectin isoform X2. (297 aa)
HRGHistidine-rich glycoprotein. (521 aa)
IL27RAInterleukin-27 receptor subunit alpha. (636 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
BMERB1BMERB domain containing 1. (204 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
GCSAMGerminal center-associated signaling and motility protein. (177 aa)
RIN3Ras and Rab interactor 3. (886 aa)
FLCNFolliculin. (579 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X3. (433 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
CNN2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (247 aa)
WASLNeural Wiskott-Aldrich syndrome protein. (489 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (488 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
ABHD2Abhydrolase domain-containing protein 2 isoform X1. (425 aa)
CCL21C-C motif chemokine ligand 21. (137 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (103 aa)
FUZLOW QUALITY PROTEIN: protein fuzzy homolog. (373 aa)
VASH1Vasohibin-1. (363 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
CXCL13C-X-C motif chemokine ligand 13. (110 aa)
NODALNodal homolog. (271 aa)
ARPINArpin. (133 aa)
DPYSL3Dihydropyrimidinase-related protein 3. (534 aa)
SEMA6Dsemaphorin-6D isoform X1; Belongs to the semaphorin family. (1086 aa)
SYNJ2BPSynaptojanin-2-binding protein. (145 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (102 aa)
CD300ACMRF35-like molecule 8. (168 aa)
ENSUMAP00000010835annotation not available (213 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (389 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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