STRINGSTRING
SFN SFN NCOA3 NCOA3 PTCH2 PTCH2 AHI1 AHI1 LHX1 LHX1 TMEM100 TMEM100 ETV2 ETV2 CYP27B1 CYP27B1 PAX6 PAX6 BMP6 BMP6 MACROH2A1 MACROH2A1 MED1 MED1 ALOX15B ALOX15B LIF LIF BMP4 BMP4 GDF2 GDF2 PRKCH PRKCH FOXN1 FOXN1 KDF1 KDF1 SFRP4 SFRP4 TP73 TP73 PTCH1 PTCH1 ACVRL1 ACVRL1 PAX8 PAX8 CYP27C1 CYP27C1 GDNF GDNF NUMA1 NUMA1 TRIM16 TRIM16 WNT10B WNT10B ENSUMAP00000007732 ENSUMAP00000007732 BMP2 BMP2 ZBED2 ZBED2 FGF2 FGF2 PROM1 PROM1 BAD BAD BTG1 BTG1 VDR VDR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (258 aa)
NCOA3Nuclear receptor coactivator. (1435 aa)
PTCH2LOW QUALITY PROTEIN: protein patched homolog 2. (1189 aa)
AHI1LOW QUALITY PROTEIN: jouberin. (1133 aa)
LHX1LOW QUALITY PROTEIN: LIM/homeobox protein Lhx1. (395 aa)
TMEM100Transmembrane protein 100. (134 aa)
ETV2ETS variant transcription factor 2. (153 aa)
CYP27B125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
PAX6Paired box protein Pax-6 isoform X2. (450 aa)
BMP6Bone morphogenetic protein 6. (364 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
ALOX15BArachidonate 15-lipoxygenase B. (524 aa)
LIFLeukemia inhibitory factor. (204 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GDF2Growth/differentiation factor 2. (402 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
FOXN1LOW QUALITY PROTEIN: forkhead box protein N1. (628 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
SFRP4Secreted frizzled-related protein 4. (254 aa)
TP73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (595 aa)
PTCH1Protein patched homolog 1. (1388 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
PAX8Paired box protein Pax-8. (459 aa)
CYP27C1Cytochrome P450 27C1; Belongs to the cytochrome P450 family. (372 aa)
GDNFGlial cell line-derived neurotrophic factor. (241 aa)
NUMA1Nuclear mitotic apparatus protein 1 isoform X1. (2143 aa)
TRIM16Tripartite motif-containing protein 16. (558 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
ENSUMAP00000007732annotation not available (389 aa)
BMP2Bone morphogenetic protein 2 isoform X2. (395 aa)
ZBED2Zinc finger BED domain-containing protein 2. (217 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
PROM1Prominin-1 isoform X1. (839 aa)
BADBcl2-associated agonist of cell death. (168 aa)
BTG1Protein BTG1. (96 aa)
VDRVitamin D3 receptor isoform X2. (427 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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