STRINGSTRING
WHRN WHRN LEF1 LEF1 SCRIB SCRIB SEC24B SEC24B KLHL5 KLHL5 HES1 HES1 PHOX2B PHOX2B ARL13B ARL13B ARCN1 ARCN1 CD3E CD3E HSPA5 HSPA5 RPGRIP1L RPGRIP1L ATRN ATRN CRKL CRKL LRRC1 LRRC1 ENSUMAP00000005722 ENSUMAP00000005722 GRID2 GRID2 FGF2 FGF2 AGTPBP1 AGTPBP1 KDM2B KDM2B CEND1 CEND1 GNPAT GNPAT LOC103667110 LOC103667110 LOC103667111 LOC103667111 ENSUMAP00000008321 ENSUMAP00000008321 WNT1 WNT1 LOC103673918 LOC103673918 CBLN1 CBLN1 EGR2 EGR2 SMO SMO ATF5 ATF5 FAIM2 FAIM2 DLL1 DLL1 KLHL1 KLHL1 PTPRS PTPRS OGDH OGDH PTPN11 PTPN11 CRK CRK SEZ6L2 SEZ6L2 EZH2 EZH2 SEZ6 SEZ6 SEMA4C SEMA4C SPTBN2 SPTBN2 TTC21B TTC21B EN2 EN2 CDK5R1 CDK5R1 ATF2 ATF2 SMAD1 SMAD1 HOXB1 HOXB1 ITGB1 ITGB1 CDK5 CDK5 RBFOX2 RBFOX2 ATP1B2 ATP1B2 TP53 TP53 AARS1 AARS1 NFIB NFIB PROX1 PROX1 SERPINE2 SERPINE2 UQCRQ UQCRQ OPHN1 OPHN1 CLP1 CLP1 ABL1 ABL1 LOC103658794 LOC103658794 CDK5R2 CDK5R2 GBA GBA COQ8B COQ8B GLI1 GLI1 PDSS2 PDSS2 KCNE1 KCNE1 TTLL1 TTLL1 NAV2 NAV2 MECP2 MECP2 LHX1 LHX1 PLXNA2 PLXNA2 XRCC1 XRCC1 LDB1 LDB1 KAT2A KAT2A ALDH1A2 ALDH1A2 KLHL4 KLHL4 RORA RORA AHI1 AHI1 FZD4 FZD4 RERE RERE CNTN1 CNTN1 B4GALT2 B4GALT2 KIF14 KIF14 CBS CBS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WHRNWhirlin. (798 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X2. (450 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (844 aa)
SEC24BProtein transport protein Sec24B. (1144 aa)
KLHL5Kelch-like protein 5. (769 aa)
HES1Transcription factor HES-1. (166 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (187 aa)
ARL13BADP-ribosylation factor-like protein 13B isoform X1. (428 aa)
ARCN1Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (488 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (201 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
RPGRIP1LLOW QUALITY PROTEIN: protein fantom. (1260 aa)
ATRNAttractin. (1372 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
LRRC1Leucine-rich repeat-containing protein 1. (493 aa)
ENSUMAP00000005722annotation not available (85 aa)
GRID2Glutamate receptor ionotropic, delta-2. (926 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
AGTPBP1Cytosolic carboxypeptidase 1. (1227 aa)
KDM2BLOW QUALITY PROTEIN: lysine-specific demethylase 2B. (685 aa)
CEND1Cell cycle exit and neuronal differentiation protein 1. (160 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (679 aa)
LOC103667110Protein FAM205A-like. (528 aa)
LOC103667111LOW QUALITY PROTEIN: protein FAM205A-like. (629 aa)
ENSUMAP00000008321annotation not available (236 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (334 aa)
LOC103673918Zinc finger protein 423-like. (115 aa)
CBLN1Cerebellin-1. (182 aa)
EGR2LOW QUALITY PROTEIN: E3 SUMO-protein ligase EGR2. (323 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (745 aa)
ATF5LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-5. (248 aa)
FAIM2Protein lifeguard 2; Belongs to the BI1 family. (319 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (695 aa)
KLHL1Kelch-like protein 1 isoform X1. (747 aa)
PTPRSReceptor-type tyrosine-protein phosphatase S. (1655 aa)
OGDH2-oxoglutarate dehydrogenase, mitochondrial. (1066 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
CRKAdapter molecule crk. (287 aa)
SEZ6L2Seizure 6-like protein 2 isoform X1. (923 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (747 aa)
SEZ6Seizure protein 6 homolog isoform X2. (983 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (843 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2227 aa)
TTC21BTetratricopeptide repeat protein 21B. (1267 aa)
EN2Homeobox protein engrailed-like. (510 aa)
CDK5R1Cyclin-dependent kinase 5 activator 1. (289 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (482 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
HOXB1Homeobox protein Hox-B1. (301 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (361 aa)
RBFOX2RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (391 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (237 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
AARS1alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (559 aa)
PROX1Prospero homeobox protein 1. (737 aa)
SERPINE2Glia-derived nexin; Belongs to the serpin family. (397 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
OPHN1Oligophrenin-1. (801 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
ABL1Tyrosine-protein kinase. (1135 aa)
LOC103658794Protein lifeguard 2-like; Belongs to the BI1 family. (285 aa)
CDK5R2Cyclin-dependent kinase 5 activator 2. (98 aa)
GBAGlucosylceramidase. (562 aa)
COQ8BaarF domain-containing protein kinase 4. (525 aa)
GLI1Zinc finger protein GLI1. (1097 aa)
PDSS2Decaprenyl-diphosphate synthase subunit 2 isoform X1; Belongs to the FPP/GGPP synthase family. (400 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1. (129 aa)
TTLL1LOW QUALITY PROTEIN: probable tubulin polyglutamylase TTLL1. (394 aa)
NAV2Neuron navigator 2. (2411 aa)
MECP2methyl-CpG-binding protein 2. (172 aa)
LHX1LOW QUALITY PROTEIN: LIM/homeobox protein Lhx1. (395 aa)
PLXNA2LOW QUALITY PROTEIN: plexin-A2. (1891 aa)
XRCC1LOW QUALITY PROTEIN: DNA repair protein XRCC1. (610 aa)
LDB1LIM domain-binding protein 1 isoform X1. (375 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (787 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X2; Belongs to the aldehyde dehydrogenase family. (521 aa)
KLHL4Kelch-like protein 4. (703 aa)
RORALOW QUALITY PROTEIN: nuclear receptor ROR-alpha. (522 aa)
AHI1LOW QUALITY PROTEIN: jouberin. (1133 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (534 aa)
REREArginine-glutamic acid dipeptide repeats protein. (1465 aa)
CNTN1Contactin-1. (1011 aa)
B4GALT2Beta-1,4-galactosyltransferase 2. (389 aa)
KIF14Kinesin-like protein KIF14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1630 aa)
CBSCystathionine beta-synthase. (557 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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