STRINGSTRING
INS-IGF2 INS-IGF2 NTF3 NTF3 PPIA PPIA ENSUMAP00000013924 ENSUMAP00000013924 FGF1 FGF1 LOC103660820 LOC103660820 ADRA2B ADRA2B INSR INSR ENSUMAP00000019674 ENSUMAP00000019674 PDGFB PDGFB ENSUMAP00000022061 ENSUMAP00000022061 RNASE4 RNASE4 ENSUMAP00000026814 ENSUMAP00000026814 GAS6 GAS6 ENSUMAP00000035005 ENSUMAP00000035005 ADRA2A ADRA2A OSBPL8 OSBPL8 PDPK1 PDPK1 ENSUMAP00000000459 ENSUMAP00000000459 MT3 MT3 ENSUMAP00000003507 ENSUMAP00000003507 LOC103664441 LOC103664441 ITGB1BP1 ITGB1BP1 NTRK3 NTRK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INS-IGF2Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (199 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
PPIAPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (170 aa)
ENSUMAP00000013924annotation not available (104 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LOC103660820Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (154 aa)
ADRA2BLOW QUALITY PROTEIN: alpha-2B adrenergic receptor. (463 aa)
INSRTyrosine-protein kinase receptor. (1375 aa)
ENSUMAP00000019674annotation not available (104 aa)
PDGFBPlatelet-derived growth factor subunit B. (234 aa)
ENSUMAP00000022061annotation not available (81 aa)
RNASE4Ribonuclease 4 isoform X1; Belongs to the pancreatic ribonuclease family. (319 aa)
ENSUMAP00000026814annotation not available (119 aa)
GAS6LOW QUALITY PROTEIN: growth arrest-specific protein 6. (614 aa)
ENSUMAP00000035005annotation not available (128 aa)
ADRA2AAdrenoceptor alpha 2A. (418 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (873 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (572 aa)
ENSUMAP00000000459annotation not available (218 aa)
MT3Metallothionein 3. (68 aa)
ENSUMAP00000003507annotation not available (155 aa)
LOC103664441Dynactin-associated protein-like. (154 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
NTRK3Tyrosine-protein kinase receptor. (861 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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