node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADRA2A | ADRA2B | ENSUMAP00000032973 | ENSUMAP00000016672 | Adrenoceptor alpha 2A. | LOW QUALITY PROTEIN: alpha-2B adrenergic receptor. | 0.448 |
ADRA2B | ADRA2A | ENSUMAP00000016672 | ENSUMAP00000032973 | LOW QUALITY PROTEIN: alpha-2B adrenergic receptor. | Adrenoceptor alpha 2A. | 0.448 |
FGF1 | INS-IGF2 | ENSUMAP00000015805 | ENSUMAP00000008147 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.606 |
FGF1 | INSR | ENSUMAP00000015805 | ENSUMAP00000019291 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Tyrosine-protein kinase receptor. | 0.682 |
FGF1 | PDGFB | ENSUMAP00000015805 | ENSUMAP00000019723 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Platelet-derived growth factor subunit B. | 0.426 |
INS-IGF2 | FGF1 | ENSUMAP00000008147 | ENSUMAP00000015805 | Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 0.606 |
INS-IGF2 | INSR | ENSUMAP00000008147 | ENSUMAP00000019291 | Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Tyrosine-protein kinase receptor. | 0.997 |
INS-IGF2 | NTF3 | ENSUMAP00000008147 | ENSUMAP00000010276 | Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.436 |
INS-IGF2 | NTRK3 | ENSUMAP00000008147 | ENSUMAP00000008127 | Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Tyrosine-protein kinase receptor. | 0.424 |
INSR | FGF1 | ENSUMAP00000019291 | ENSUMAP00000015805 | Tyrosine-protein kinase receptor. | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 0.682 |
INSR | INS-IGF2 | ENSUMAP00000019291 | ENSUMAP00000008147 | Tyrosine-protein kinase receptor. | Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.997 |
INSR | NTF3 | ENSUMAP00000019291 | ENSUMAP00000010276 | Tyrosine-protein kinase receptor. | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.717 |
INSR | PDPK1 | ENSUMAP00000019291 | ENSUMAP00000031700 | Tyrosine-protein kinase receptor. | 3-phosphoinositide-dependent protein kinase 1 isoform X1. | 0.416 |
LOC103660820 | PPIA | ENSUMAP00000015909 | ENSUMAP00000013002 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | 0.901 |
NTF3 | INS-IGF2 | ENSUMAP00000010276 | ENSUMAP00000008147 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.436 |
NTF3 | INSR | ENSUMAP00000010276 | ENSUMAP00000019291 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | Tyrosine-protein kinase receptor. | 0.717 |
NTF3 | NTRK3 | ENSUMAP00000010276 | ENSUMAP00000008127 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | Tyrosine-protein kinase receptor. | 0.805 |
NTRK3 | INS-IGF2 | ENSUMAP00000008127 | ENSUMAP00000008147 | Tyrosine-protein kinase receptor. | Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.424 |
NTRK3 | NTF3 | ENSUMAP00000008127 | ENSUMAP00000010276 | Tyrosine-protein kinase receptor. | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. | 0.805 |
PDGFB | FGF1 | ENSUMAP00000019723 | ENSUMAP00000015805 | Platelet-derived growth factor subunit B. | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 0.426 |