STRINGSTRING
DDX58 DDX58 MYD88 MYD88 CHI3L1 CHI3L1 ELANE ELANE TLR8 TLR8 TLR7 TLR7 F2RL1 F2RL1 CD2 CD2 TLR4 TLR4 MAVS MAVS CD74 CD74 ADIPOQ ADIPOQ BCL10 BCL10 NOD1 NOD1 AFAP1L2 AFAP1L2 GDF2 GDF2 TNF TNF ENSUMAP00000020575 ENSUMAP00000020575 PYCARD PYCARD NOS2 NOS2 CD14 CD14 TLR3 TLR3 LOC103668179 LOC103668179 CD58 CD58 RAB1B RAB1B RELA RELA F3 F3 FADD FADD STAT3 STAT3 PARK7 PARK7 PRKD2 PRKD2 LOC103679927 LOC103679927 ENSUMAP00000032829 ENSUMAP00000032829 RAB1A RAB1A ENSUMAP00000027960 ENSUMAP00000027960 DDIT3 DDIT3 RIPK1 RIPK1 HMGB1 HMGB1 SYK SYK CLEC7A CLEC7A LEP LEP NOD2 NOD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDX58Probable ATP-dependent RNA helicase DDX58 isoform X1. (928 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
CHI3L1Chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (384 aa)
ELANENeutrophil elastase. (269 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
F2RL1Proteinase-activated receptor 2. (399 aa)
CD2T-cell surface antigen CD2. (344 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
MAVSLOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein. (710 aa)
CD74LOW QUALITY PROTEIN: HLA class II histocompatibility antigen gamma chain. (279 aa)
ADIPOQAdiponectin isoform X2. (297 aa)
BCL10BCL10 immune signaling adaptor. (234 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (263 aa)
AFAP1L2Actin filament-associated protein 1-like 2. (763 aa)
GDF2Growth/differentiation factor 2. (402 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ENSUMAP00000020575annotation not available (177 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1096 aa)
CD14Monocyte differentiation antigen CD14 isoform X2. (439 aa)
TLR3Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family. (905 aa)
LOC103668179LOW QUALITY PROTEIN: high mobility group protein B1-like. (200 aa)
CD58Lymphocyte function-associated antigen 3. (236 aa)
RAB1BRas-related protein Rab-1B isoform X2. (277 aa)
RELATranscription factor p65. (585 aa)
F3Tissue factor. (295 aa)
FADDFAS-associated death domain protein. (192 aa)
STAT3Signal transducer and activator of transcription. (838 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (833 aa)
LOC103679927Ficolin-1-like isoform X3. (326 aa)
ENSUMAP00000032829annotation not available (407 aa)
RAB1ARas-related protein Rab-1A. (211 aa)
ENSUMAP00000027960annotation not available (155 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
HMGB1High mobility group protein B1. (215 aa)
SYKTyrosine-protein kinase SYK; Belongs to the protein kinase superfamily. Tyr protein kinase family. (610 aa)
CLEC7AC-type lectin domain family 7 member A isoform X2. (202 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (817 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.