34 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRPV1	Transient receptor potential cation channel subfamily V member 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (851 aa)
	SLU7	SLU7 homolog, splicing factor. (637 aa)
	SLC52A3	Solute carrier family 52, riboflavin transporter, member 3. (472 aa)
	HTRA2	LOW QUALITY PROTEIN: serine protease HTRA2, mitochondrial. (455 aa)
	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
	TFEC	Transcription factor EC isoform X1. (384 aa)
	TRPV4	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (837 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (733 aa)
	BAG3	BAG family molecular chaperone regulator 3. (551 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (378 aa)
	HSBP1L1	Heat shock factor-binding protein 1-like protein 1. (76 aa)
	HSP90AB1	Heat shock protein HSP 90-beta. (699 aa)
	VCP	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (761 aa)
	ARPP21	cAMP-regulated phosphoprotein 21 isoform X2. (834 aa)
	ANO1	Anoctamin. (972 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (244 aa)
	CLPB	Caseinolytic peptidase B protein homolog isoform X1. (677 aa)
	RBBP7	RB binding protein 7, chromatin remodeling factor. (391 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	DHX36	ATP-dependent RNA helicase DHX36. (1011 aa)
	DAXX	Death domain-associated protein 6. (737 aa)
	NF1	Neurofibromin. (2862 aa)
	LOC103672401	LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like. (91 aa)
	ENSUMAP00000021493	annotation not available (84 aa)
	HMOX1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (264 aa)
	TPR	Nucleoprotein TPR. (2425 aa)
	PDCD6	Programmed cell death protein 6. (185 aa)
	ENSUMAP00000030897	annotation not available (310 aa)
	SCARA5	Scavenger receptor class A member 5. (345 aa)
	ENSUMAP00000031783	annotation not available (71 aa)
	LOC103659967	Heat shock factor-binding protein 1-like. (74 aa)
	HIKESHI	Heat shock protein nuclear import factor hikeshi. (197 aa)
	TCIM	Transcriptional and immune response regulator. (106 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAG3	HSP90AB1	ENSUMAP00000003930	ENSUMAP00000006836	BAG family molecular chaperone regulator 3.	Heat shock protein HSP 90-beta.	0.558
CLPB	ENSUMAP00000030897	ENSUMAP00000011574	ENSUMAP00000030897	Caseinolytic peptidase B protein homolog isoform X1.	annotation not available	0.673
CLPB	HIKESHI	ENSUMAP00000011574	ENSUMAP00000033158	Caseinolytic peptidase B protein homolog isoform X1.	Heat shock protein nuclear import factor hikeshi.	0.587
CLPB	HSP90AA1	ENSUMAP00000011574	ENSUMAP00000002841	Caseinolytic peptidase B protein homolog isoform X1.	Heat shock protein 90 alpha family class A member 1.	0.673
CLPB	HSP90AB1	ENSUMAP00000011574	ENSUMAP00000006836	Caseinolytic peptidase B protein homolog isoform X1.	Heat shock protein HSP 90-beta.	0.673
CLPB	LOC103672401	ENSUMAP00000011574	ENSUMAP00000021241	Caseinolytic peptidase B protein homolog isoform X1.	LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like.	0.673
DHX36	SLU7	ENSUMAP00000016196	ENSUMAP00000000041	ATP-dependent RNA helicase DHX36.	SLU7 homolog, splicing factor.	0.564
ENSUMAP00000030897	CLPB	ENSUMAP00000030897	ENSUMAP00000011574	annotation not available	Caseinolytic peptidase B protein homolog isoform X1.	0.673
ENSUMAP00000030897	ENSUMAP00000031783	ENSUMAP00000030897	ENSUMAP00000031783	annotation not available	annotation not available	0.482
ENSUMAP00000030897	VCP	ENSUMAP00000030897	ENSUMAP00000008374	annotation not available	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family.	0.509
ENSUMAP00000030897	YWHAE	ENSUMAP00000030897	ENSUMAP00000013544	annotation not available	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family.	0.544
ENSUMAP00000031783	ENSUMAP00000030897	ENSUMAP00000031783	ENSUMAP00000030897	annotation not available	annotation not available	0.482
ENSUMAP00000031783	HSP90AA1	ENSUMAP00000031783	ENSUMAP00000002841	annotation not available	Heat shock protein 90 alpha family class A member 1.	0.482
ENSUMAP00000031783	HSP90AB1	ENSUMAP00000031783	ENSUMAP00000006836	annotation not available	Heat shock protein HSP 90-beta.	0.482
ENSUMAP00000031783	LOC103672401	ENSUMAP00000031783	ENSUMAP00000021241	annotation not available	LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like.	0.482
HIKESHI	CLPB	ENSUMAP00000033158	ENSUMAP00000011574	Heat shock protein nuclear import factor hikeshi.	Caseinolytic peptidase B protein homolog isoform X1.	0.587
HSP90AA1	CLPB	ENSUMAP00000002841	ENSUMAP00000011574	Heat shock protein 90 alpha family class A member 1.	Caseinolytic peptidase B protein homolog isoform X1.	0.673
HSP90AA1	ENSUMAP00000031783	ENSUMAP00000002841	ENSUMAP00000031783	Heat shock protein 90 alpha family class A member 1.	annotation not available	0.482
HSP90AA1	HSP90AB1	ENSUMAP00000002841	ENSUMAP00000006836	Heat shock protein 90 alpha family class A member 1.	Heat shock protein HSP 90-beta.	0.901
HSP90AA1	VCP	ENSUMAP00000002841	ENSUMAP00000008374	Heat shock protein 90 alpha family class A member 1.	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family.	0.509