STRINGSTRING
TNFRSF11A TNFRSF11A CDIP1 CDIP1 ENSUMAP00000003291 ENSUMAP00000003291 TNFRSF18 TNFRSF18 TNFRSF4 TNFRSF4 GSDME GSDME ZC3H12A ZC3H12A SMPD1 SMPD1 ANKRD1 ANKRD1 PTK2B PTK2B ILK ILK MAPK1 MAPK1 DAB2IP DAB2IP TRAF1 TRAF1 ADIPOQ ADIPOQ TNFRSF17 TNFRSF17 ENSUMAP00000005502 ENSUMAP00000005502 TRIM32 TRIM32 SMPD4 SMPD4 TNFRSF21 TNFRSF21 CRHBP CRHBP CHI3L1 CHI3L1 TRAF3 TRAF3 GPER1 GPER1 CCL19 CCL19 CCL21 CCL21 CXCL8 CXCL8 LRRC7 LRRC7 SIRT1 SIRT1 CACTIN CACTIN TNFRSF1A TNFRSF1A CIB1 CIB1 GPD1 GPD1 ERBIN ERBIN TANK TANK BAG4 BAG4 TMEM130 TMEM130 ADAM9 ADAM9 KRT8 KRT8 KRT18 KRT18 INPP5K INPP5K ZFP36L1 ZFP36L1 PIAS3 PIAS3 RELA RELA RPS3 RPS3 ZFAND6 ZFAND6 MAPK3 MAPK3 NFKBIA NFKBIA CD70 CD70 CD58 CD58 TRAF4 TRAF4 PLVAP PLVAP FAS FAS CCL24 CCL24 CCL26 CCL26 TXNDC17 TXNDC17 MAP4K3 MAP4K3 SPHK1 SPHK1 ENSUMAP00000018377 ENSUMAP00000018377 ADAMTS12 ADAMTS12 PYCARD PYCARD CCL25 CCL25 CARD14 CARD14 FABP4 FABP4 CLDN18 CLDN18 TNF TNF SLC2A4 SLC2A4 CCL7 CCL7 CCL8 CCL8 CCL13 CCL13 CCL1 CCL1 NFE2L2 NFE2L2 TNFSF11 TNFSF11 YBX3 YBX3 NUB1 NUB1 DHX9 DHX9 CCL14 CCL14 CCL4 CCL4 LOC103667300 LOC103667300 LOC103667299 LOC103667299 LOC103667298 LOC103667298 CCL3L3 CCL3L3 TP53 TP53 ENSUMAP00000023213 ENSUMAP00000023213 EDA2R EDA2R PID1 PID1 LOC103667626 LOC103667626 TRAF6 TRAF6 CCL20 CCL20 NR1D1 NR1D1 ARHGEF2 ARHGEF2 RIPK1 RIPK1 SMPD3 SMPD3 UBD UBD ACTN4 ACTN4 ZFP36 ZFP36 GBA GBA FOXO3 FOXO3 DCSTAMP DCSTAMP TNFSF18 TNFSF18 TRADD TRADD STAT1 STAT1 EXT1 EXT1 TRAF5 TRAF5 CASP10 CASP10 CASP8 CASP8 CCL17 CCL17 CX3CL1 CX3CL1 CCL22 CCL22 HYAL2 HYAL2 HYAL3 HYAL3 HAS2 HAS2 TNFRSF1B TNFRSF1B TNFSF13B TNFSF13B NPNT NPNT CHUK CHUK TRAF2 TRAF2 MYOD1 MYOD1 ADAM10 ADAM10 YTHDC2 YTHDC2 RORA RORA COMMD7 COMMD7 FCAR FCAR OCSTAMP OCSTAMP TRAF3IP2 TRAF3IP2 IKBKB IKBKB SFRP1 SFRP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (274 aa)
CDIP1Cell death-inducing p53-target protein 1. (278 aa)
ENSUMAP00000003291annotation not available (65 aa)
TNFRSF18Tumor necrosis factor receptor superfamily member 18. (238 aa)
TNFRSF4Tumor necrosis factor receptor superfamily member 4. (260 aa)
GSDMENon-syndromic hearing impairment protein 5. (495 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ILKIntegrin-linked protein kinase. (452 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
DAB2IPDisabled homolog 2-interacting protein. (877 aa)
TRAF1TNF receptor-associated factor. (408 aa)
ADIPOQAdiponectin isoform X2. (297 aa)
TNFRSF17Tumor necrosis factor receptor superfamily member 17. (175 aa)
ENSUMAP00000005502annotation not available (110 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32. (654 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (857 aa)
TNFRSF21Tumor necrosis factor receptor superfamily member 21. (637 aa)
CRHBPCorticotropin-releasing factor-binding protein. (305 aa)
CHI3L1Chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (384 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
CCL19C-C motif chemokine. (115 aa)
CCL21C-C motif chemokine ligand 21. (137 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (150 aa)
LRRC7Leucine-rich repeat-containing protein 7. (1544 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X2. (446 aa)
CACTINCactin. (189 aa)
TNFRSF1ALOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A. (507 aa)
CIB1Calcium and integrin-binding protein 1. (199 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
ERBINProtein LAP2 isoform X1. (1472 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X2. (426 aa)
BAG4BAG family molecular chaperone regulator 4 isoform X1. (457 aa)
TMEM130Transmembrane protein 130. (317 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (819 aa)
KRT8Keratin, type II cytoskeletal 8; Belongs to the intermediate filament family. (396 aa)
KRT18Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (417 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (455 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1. (338 aa)
PIAS3E3 SUMO-protein ligase PIAS3 isoform X2. (606 aa)
RELATranscription factor p65. (585 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
ZFAND6AN1-type zinc finger protein 6 isoform X4. (208 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
NFKBIANF-kappa-B inhibitor alpha. (253 aa)
CD70CD70 antigen; Belongs to the tumor necrosis factor family. (195 aa)
CD58Lymphocyte function-associated antigen 3. (236 aa)
TRAF4TNF receptor-associated factor. (435 aa)
PLVAPPlasmalemma vesicle-associated protein. (441 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (351 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
CCL26C-C motif chemokine. (93 aa)
TXNDC17Thioredoxin domain-containing protein 17. (95 aa)
MAP4K3Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (831 aa)
SPHK1LOW QUALITY PROTEIN: sphingosine kinase 1. (387 aa)
ENSUMAP00000018377annotation not available (92 aa)
ADAMTS12A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X1. (1601 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
CCL25C-C motif chemokine 25 isoform X1. (162 aa)
CARD14Caspase recruitment domain-containing protein 14. (1010 aa)
FABP4Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (142 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (340 aa)
CCL7C-C motif chemokine. (99 aa)
CCL8C-C motif chemokine. (99 aa)
CCL13C-C motif chemokine. (98 aa)
CCL1C-C motif chemokine. (97 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X2. (590 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
YBX3Y-box-binding protein 3. (302 aa)
NUB1Negative regulator of ubiquitin like proteins 1. (619 aa)
DHX9ATP-dependent RNA helicase A. (1276 aa)
CCL14C-C motif chemokine 14. (179 aa)
CCL4C-C motif chemokine. (83 aa)
LOC103667300C-C motif chemokine 15-like isoform X2. (118 aa)
LOC103667299Regakine-1-like. (93 aa)
LOC103667298C-C motif chemokine. (93 aa)
CCL3L3C-C motif chemokine. (93 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ENSUMAP00000023213annotation not available (63 aa)
EDA2RTumor necrosis factor receptor superfamily member 27 isoform X3. (309 aa)
PID1PTB-containing, cubilin and LRP1-interacting protein isoform X2. (220 aa)
LOC103667626Cytokine SCM-1 beta-like. (112 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
CCL20C-C motif chemokine. (96 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2. (725 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
UBDLOW QUALITY PROTEIN: ubiquitin D-like. (154 aa)
ACTN4Alpha-actinin-4. (853 aa)
ZFP36Tristetraprolin. (323 aa)
GBAGlucosylceramidase. (562 aa)
FOXO3Forkhead box protein O3. (453 aa)
DCSTAMPDendritic cell-specific transmembrane protein isoform X2. (470 aa)
TNFSF18Tumor necrosis factor ligand superfamily member 18. (178 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (314 aa)
STAT1Signal transducer and activator of transcription. (809 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (501 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (582 aa)
CASP10Caspase-10 isoform X1; Belongs to the peptidase C14A family. (481 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
CCL17C-C motif chemokine. (109 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (412 aa)
CCL22C-C motif chemokine. (93 aa)
HYAL2Hyaluronidase. (472 aa)
HYAL3Hyaluronidase. (417 aa)
HAS2Hyaluronan synthase 2 isoform X1. (588 aa)
TNFRSF1BLOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1B. (313 aa)
TNFSF13BTumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (293 aa)
NPNTNephronectin. (562 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (494 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (316 aa)
ADAM10Disintegrin and metalloproteinase domain-containing protein 10. (674 aa)
YTHDC2Probable ATP-dependent RNA helicase YTHDC2. (1376 aa)
RORALOW QUALITY PROTEIN: nuclear receptor ROR-alpha. (522 aa)
COMMD7COMM domain-containing protein 7. (184 aa)
FCARImmunoglobulin alpha Fc receptor isoform X1. (273 aa)
OCSTAMPLOW QUALITY PROTEIN: osteoclast stimulatory transmembrane protein. (481 aa)
TRAF3IP2TRAF3 interacting protein 2. (563 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.