STRINGSTRING
KMT2A KMT2A ENSUMAP00000001654 ENSUMAP00000001654 RUVBL2 RUVBL2 TAF4 TAF4 WDR4 WDR4 DNMT3L DNMT3L WDR5B WDR5B ZNF335 ZNF335 EZH1 EZH1 TRMT61A TRMT61A ENSUMAP00000033666 ENSUMAP00000033666 EED EED SNRPD2 SNRPD2 WDR5 WDR5 RNF2 RNF2 ENSUMAP00000030235 ENSUMAP00000030235 RBM15B RBM15B LOC103680203 LOC103680203 WDR82 WDR82 KDM6A KDM6A KMT2B KMT2B METTL1 METTL1 TRMT61B TRMT61B DPY30 DPY30 ENSUMAP00000027192 ENSUMAP00000027192 HSD17B10 HSD17B10 HCFC2 HCFC2 RIOK1 RIOK1 CBLL1 CBLL1 JARID2 JARID2 PRDM4 PRDM4 LAS1L LAS1L ENSUMAP00000023433 ENSUMAP00000023433 LOC103658053 LOC103658053 SENP3 SENP3 VIRMA VIRMA ENSUMAP00000021995 ENSUMAP00000021995 KMT2C KMT2C KANSL1 KANSL1 SUZ12 SUZ12 N6AMT1 N6AMT1 RUVBL1 RUVBL1 PAXIP1 PAXIP1 LOC103660346 LOC103660346 PELP1 PELP1 DYDC2 DYDC2 DYDC1 DYDC1 KAT8 KAT8 PRMT5 PRMT5 SETD1A SETD1A WDR77 WDR77 MAX MAX TEX10 TEX10 PHF1 PHF1 MGA MGA EZH2 EZH2 ENSUMAP00000015552 ENSUMAP00000015552 CLNS1A CLNS1A PRPF31 PRPF31 PAGR1 PAGR1 MTF2 MTF2 TAF6 TAF6 CBX5 CBX5 ERH ERH ASH2L ASH2L ENSUMAP00000011850 ENSUMAP00000011850 RBBP7 RBBP7 RBBP4 RBBP4 MEN1 MEN1 SIRT1 SIRT1 MCRS1 MCRS1 KMT2D KMT2D ENSUMAP00000008606 ENSUMAP00000008606 SETD1B SETD1B NCOA6 NCOA6 TRMT6 TRMT6 METTL3 METTL3 CHD8 CHD8 PHF20 PHF20 PHF19 PHF19 ENSUMAP00000005096 ENSUMAP00000005096 RBBP5 RBBP5 AEBP2 AEBP2 METTL14 METTL14 TRMT10C TRMT10C CXXC1 CXXC1 PRMT1 PRMT1 E2F6 E2F6 INO80C INO80C ENSUMAP00000002159 ENSUMAP00000002159
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (323 aa)
ENSUMAP00000001654annotation not available (123 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
TAF4LOW QUALITY PROTEIN: transcription initiation factor TFIID subunit 4. (723 aa)
WDR4tRNA (Guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4. (390 aa)
DNMT3LDNA (Cytosine-5)-methyltransferase 3-like. (326 aa)
WDR5BWD repeat-containing protein 5B. (330 aa)
ZNF335Zinc finger protein 335. (1320 aa)
EZH1Histone-lysine N-methyltransferase EZH1. (735 aa)
TRMT61AtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (352 aa)
ENSUMAP00000033666annotation not available (53 aa)
EEDPolycomb protein EED. (421 aa)
SNRPD2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
WDR5COMPASS component SWD3. (347 aa)
RNF2E3 ubiquitin-protein ligase RING2 isoform X1. (349 aa)
ENSUMAP00000030235annotation not available (73 aa)
RBM15BPutative RNA-binding protein 15B. (214 aa)
LOC103680203LOW QUALITY PROTEIN: lysine-specific demethylase 6A-like. (1394 aa)
WDR82WD repeat-containing protein 82. (256 aa)
KDM6ALysine-specific demethylase 6A. (1347 aa)
KMT2BHistone-lysine N-methyltransferase 2B. (2526 aa)
METTL1tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (277 aa)
TRMT61BtRNA (Adenine(58)-N(1))-methyltransferase, mitochondrial. (479 aa)
DPY30Protein dpy-30 homolog. (99 aa)
ENSUMAP00000027192annotation not available (113 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (294 aa)
HCFC2Host cell factor C2. (780 aa)
RIOK1Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (591 aa)
CBLL1E3 ubiquitin-protein ligase Hakai isoform X1. (577 aa)
JARID2LOW QUALITY PROTEIN: protein Jumonji. (1137 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (808 aa)
LAS1LLOW QUALITY PROTEIN: ribosomal biogenesis protein LAS1L. (405 aa)
ENSUMAP00000023433annotation not available (256 aa)
LOC103658053Enhancer of rudimentary homolog; May have a role in the cell cycle. (121 aa)
SENP3LOW QUALITY PROTEIN: sentrin-specific protease 3. (568 aa)
VIRMAVir like m6A methyltransferase associated. (1812 aa)
ENSUMAP00000021995annotation not available (342 aa)
KMT2CHistone-lysine N-methyltransferase 2C. (778 aa)
KANSL1KAT8 regulatory NSL complex subunit 1. (1103 aa)
SUZ12Polycomb protein SUZ12. (686 aa)
N6AMT1hemK methyltransferase family member 2 isoform X1. (219 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
PAXIP1PAX-interacting protein 1. (908 aa)
LOC103660346Chromatin complexes subunit BAP18. (157 aa)
PELP1Proline-, glutamic acid- and leucine-rich protein 1. (943 aa)
DYDC2LOW QUALITY PROTEIN: DPY30 domain-containing protein 2. (134 aa)
DYDC1DPY30 domain-containing protein 1. (177 aa)
KAT8Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (446 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
SETD1ALOW QUALITY PROTEIN: histone-lysine N-methyltransferase SETD1A. (1443 aa)
WDR77Methylosome protein 50. (342 aa)
MAXProtein max. (194 aa)
TEX10Testis-expressed sequence 10 protein. (929 aa)
PHF1PHD finger protein 1 isoform X4. (429 aa)
MGAMAX gene-associated protein. (3113 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (747 aa)
ENSUMAP00000015552annotation not available (139 aa)
CLNS1ALOW QUALITY PROTEIN: methylosome subunit pICln. (113 aa)
PRPF31U4/U6 small nuclear ribonucleoprotein Prp31. (499 aa)
PAGR1PAXIP1-associated glutamate-rich protein 1. (254 aa)
MTF2Metal-response element-binding transcription factor 2 isoform X1. (593 aa)
TAF6LOW QUALITY PROTEIN: transcription initiation factor TFIID subunit 6. (667 aa)
CBX5Chromobox protein homolog 5. (191 aa)
ERHEnhancer of rudimentary homolog. (164 aa)
ASH2LASH2 like, histone lysine methyltransferase complex subunit. (628 aa)
ENSUMAP00000011850annotation not available (104 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (391 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (390 aa)
MEN1Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (422 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X2. (446 aa)
MCRS1Microspherule protein 1 isoform X2. (462 aa)
KMT2DLOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2D. (811 aa)
ENSUMAP00000008606annotation not available (116 aa)
SETD1BHistone-lysine N-methyltransferase SETD1B. (115 aa)
NCOA6Nuclear receptor coactivator 6 isoform X1. (2032 aa)
TRMT6tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (502 aa)
METTL3N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2590 aa)
PHF20PHD finger protein 20. (1013 aa)
PHF19PHD finger protein 19. (472 aa)
ENSUMAP00000005096annotation not available (174 aa)
RBBP5RB binding protein 5, histone lysine methyltransferase complex subunit. (538 aa)
AEBP2Zinc finger protein AEBP2. (274 aa)
METTL14N6-adenosine-methyltransferase subunit METTL14; Belongs to the MT-A70-like family. (456 aa)
TRMT10CtRNA methyltransferase 10C, mitochondrial RNase P subunit. (415 aa)
CXXC1CXXC-type zinc finger protein 1. (684 aa)
PRMT1Protein arginine N-methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (286 aa)
E2F6Transcription factor E2F6 isoform X1. (229 aa)
INO80CINO80 complex subunit C. (192 aa)
ENSUMAP00000002159annotation not available (370 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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