(83 nodes) Limb morphogenesis network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLXNA2	LOW QUALITY PROTEIN: plexin-A2. (1891 aa)
	TBX4	LOW QUALITY PROTEIN: T-box transcription factor TBX4. (521 aa)
	PCSK5	Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (852 aa)
	IFT140	Intraflagellar transport protein 140 homolog isoform X1. (1459 aa)
	DLX5	Homeobox protein DLX-5. (285 aa)
	DLX6	Homeobox protein DLX-6. (167 aa)
	WDPCP	LOW QUALITY PROTEIN: WD repeat-containing and planar cell polarity effector protein fritz homolog. (690 aa)
	EXT1	Exostosin-1; Belongs to the glycosyltransferase 47 family. (501 aa)
	IHH	Indian hedgehog protein. (145 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa)
	COL3A1	Collagen alpha-1(III) chain. (762 aa)
	RARB	Retinoic acid receptor beta-like. (441 aa)
	CHST11	Carbohydrate sulfotransferase. (132 aa)
	GREM1	Gremlin. (232 aa)
	SFRP2	Secreted frizzled-related protein 2. (299 aa)
	OSR2	Odd-skipped related transciption factor 2. (276 aa)
	TMEM107	Transmembrane protein 107 isoform X1. (140 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
	PITX1	Homeobox protein. (310 aa)
	FLVCR1	LOW QUALITY PROTEIN: feline leukemia virus subgroup C receptor-related protein 1. (448 aa)
	TFAP2A	LOW QUALITY PROTEIN: transcription factor AP-2-alpha. (494 aa)
	ATRX	LOW QUALITY PROTEIN: transcriptional regulator ATRX. (2471 aa)
	LEF1	Lymphoid enhancer-binding factor 1 isoform X2. (450 aa)
	WDR19	WD repeat-containing protein 19. (1283 aa)
	IFT52	Intraflagellar transport protein 52 homolog isoform X1. (454 aa)
	HOXA9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
	ENSUMAP00000001989	annotation not available (146 aa)
	TBC1D32	Protein broad-minded. (1307 aa)
	RNF165	RING finger protein 165. (348 aa)
	RPGRIP1L	LOW QUALITY PROTEIN: protein fantom. (1260 aa)
	SMAD4	Mothers against decapentaplegic homolog. (546 aa)
	ZBTB16	Zinc finger and BTB domain-containing protein 16. (673 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	TFAP2B	Transcription factor AP-2-beta. (460 aa)
	GDF5	LOW QUALITY PROTEIN: growth/differentiation factor 5. (306 aa)
	SALL1	LOW QUALITY PROTEIN: sal-like protein 1. (144 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	HNF1A	Hepatocyte nuclear factor 1-alpha. (660 aa)
	B9D1	B9 domain-containing protein 1. (200 aa)
	ENSUMAP00000009652	annotation not available (108 aa)
	GNA12	Guanine nucleotide-binding protein subunit alpha-12. (294 aa)
	TFAP2E	Transcription factor AP-2-epsilon. (416 aa)
	FRAS1	Extracellular matrix protein FRAS1. (3981 aa)
	PTCH1	Protein patched homolog 1. (1388 aa)
	IMPAD1	Inositol monophosphatase 3. (167 aa)
	GLI3	Transcriptional activator GLI3. (524 aa)
	RARG	Retinoic acid receptor gamma isoform X1. (458 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	HOXC10	Homeobox protein Hox-C10. (342 aa)
	TBX5	T-box transcription factor TBX5. (474 aa)
	TBX3	LOW QUALITY PROTEIN: T-box transcription factor TBX3. (130 aa)
	RECK	Reversion-inducing cysteine-rich protein with Kazal motifs. (926 aa)
	NIPBL	Nipped-B protein. (2805 aa)
	BCL2L11	Bcl-2-like protein 11 isoform X11. (84 aa)
	GPC3	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (625 aa)
	LOC103665481	Putative Bcl-2 homologous antagonist/killer 2. (349 aa)
	PKDCC	Protein kinase domain-containing protein, cytoplasmic. (291 aa)
	ALX3	Homeobox protein aristaless-like 3. (371 aa)
	CHD7	chromodomain-helicase-DNA-binding protein 7. (2976 aa)
	LRP5	Low-density lipoprotein receptor-related protein 5. (1602 aa)
	SEMA3C	Semaphorin-3C; Belongs to the semaphorin family. (750 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	LRP4	Low-density lipoprotein receptor-related protein 4. (1742 aa)
	LMBR1	Limb region 1 protein homolog; Belongs to the LIMR family. (510 aa)
	SHH	Sonic hedgehog protein. (168 aa)
	TMEM231	Transmembrane protein 231. (289 aa)
	TULP3	Tubby-like protein; Belongs to the TUB family. (462 aa)
	ECE1	Endothelin-converting enzyme 1. (758 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	MAP3K20	Mitogen-activated protein kinase kinase kinase MLT isoform X1. (456 aa)
	ALX4	Homeobox protein aristaless-like 4. (238 aa)
	LNPK	Lunapark, ER junction formation factor. (429 aa)
	HOXD10	Homeobox protein Hox-D10. (340 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SULF1	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (886 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2. (2444 aa)
	SALL4	Sal-like protein 4. (1021 aa)
	FREM2	FRAS1-related extracellular matrix protein 2. (3173 aa)
	ALDH1A2	Retinal dehydrogenase 2 isoform X2; Belongs to the aldehyde dehydrogenase family. (521 aa)
	OSR1	Protein odd-skipped-related 1. (272 aa)
	MKS1	MKS transition zone complex subunit 1. (559 aa)
	INTU	Protein inturned. (938 aa)
	CYP26B1	Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (304 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A2	CYP26B1	ENSUMAP00000032804	ENSUMAP00000031257	Retinal dehydrogenase 2 isoform X2; Belongs to the aldehyde dehydrogenase family.	Cytochrome P450 26B1; Belongs to the cytochrome P450 family.	0.941
ALDH1A2	RDH10	ENSUMAP00000032804	ENSUMAP00000025917	Retinal dehydrogenase 2 isoform X2; Belongs to the aldehyde dehydrogenase family.	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.980
ALX3	PCSK5	ENSUMAP00000018526	ENSUMAP00000030665	Homeobox protein aristaless-like 3.	Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family.	0.458
ATRX	NIPBL	ENSUMAP00000025399	ENSUMAP00000015561	LOW QUALITY PROTEIN: transcriptional regulator ATRX.	Nipped-B protein.	0.671
B9D1	MKS1	ENSUMAP00000008117	ENSUMAP00000031790	B9 domain-containing protein 1.	MKS transition zone complex subunit 1.	0.979
B9D1	RPGRIP1L	ENSUMAP00000008117	ENSUMAP00000003351	B9 domain-containing protein 1.	LOW QUALITY PROTEIN: protein fantom.	0.779
B9D1	TMEM107	ENSUMAP00000008117	ENSUMAP00000023732	B9 domain-containing protein 1.	Transmembrane protein 107 isoform X1.	0.871
B9D1	TMEM231	ENSUMAP00000008117	ENSUMAP00000019858	B9 domain-containing protein 1.	Transmembrane protein 231.	0.916
B9D1	WDR19	ENSUMAP00000008117	ENSUMAP00000000750	B9 domain-containing protein 1.	WD repeat-containing protein 19.	0.441
BCL2L11	LOC103665481	ENSUMAP00000015720	ENSUMAP00000016562	Bcl-2-like protein 11 isoform X11.	Putative Bcl-2 homologous antagonist/killer 2.	0.916
BMP4	BMPR1A	ENSUMAP00000021648	ENSUMAP00000019489	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.996
BMP4	DLX5	ENSUMAP00000021648	ENSUMAP00000029723	Bone morphogenetic protein 4.	Homeobox protein DLX-5.	0.632
BMP4	ENSUMAP00000009652	ENSUMAP00000021648	ENSUMAP00000009652	Bone morphogenetic protein 4.	annotation not available	0.645
BMP4	FGF10	ENSUMAP00000021648	ENSUMAP00000007657	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.817
BMP4	FGF9	ENSUMAP00000021648	ENSUMAP00000020627	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.588
BMP4	GDF5	ENSUMAP00000021648	ENSUMAP00000006468	Bone morphogenetic protein 4.	LOW QUALITY PROTEIN: growth/differentiation factor 5.	0.438
BMP4	GREM1	ENSUMAP00000021648	ENSUMAP00000021750	Bone morphogenetic protein 4.	Gremlin.	0.937
BMP4	IHH	ENSUMAP00000021648	ENSUMAP00000026096	Bone morphogenetic protein 4.	Indian hedgehog protein.	0.786
BMP4	LEF1	ENSUMAP00000021648	ENSUMAP00000000504	Bone morphogenetic protein 4.	Lymphoid enhancer-binding factor 1 isoform X2.	0.603
BMP4	PTCH1	ENSUMAP00000021648	ENSUMAP00000013120	Bone morphogenetic protein 4.	Protein patched homolog 1.	0.525