(17 nodes) Embryonic hindlimb morphogenesis network (Ursus maritimus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	RPGRIP1L	LOW QUALITY PROTEIN: protein fantom. (1260 aa)
	ZBTB16	Zinc finger and BTB domain-containing protein 16. (673 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	TBX3	LOW QUALITY PROTEIN: T-box transcription factor TBX3. (130 aa)
	ENSUMAP00000009652	annotation not available (108 aa)
	RARG	Retinoic acid receptor gamma isoform X1. (458 aa)
	OSR1	Protein odd-skipped-related 1. (272 aa)
	OSR2	Odd-skipped related transciption factor 2. (276 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
	PITX1	Homeobox protein. (310 aa)
	RARB	Retinoic acid receptor beta-like. (441 aa)
	TBX4	LOW QUALITY PROTEIN: T-box transcription factor TBX4. (521 aa)
	GPC3	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (625 aa)
	ALX3	Homeobox protein aristaless-like 3. (371 aa)
	CHD7	chromodomain-helicase-DNA-binding protein 7. (2976 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	ALX4	Homeobox protein aristaless-like 4. (238 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	ENSUMAP00000009652	ENSUMAP00000021648	ENSUMAP00000009652	Bone morphogenetic protein 4.	annotation not available	0.645
BMP4	TBX3	ENSUMAP00000021648	ENSUMAP00000014725	Bone morphogenetic protein 4.	LOW QUALITY PROTEIN: T-box transcription factor TBX3.	0.483
ENSUMAP00000009652	BMP4	ENSUMAP00000009652	ENSUMAP00000021648	annotation not available	Bone morphogenetic protein 4.	0.645
MED1	RARB	ENSUMAP00000023808	ENSUMAP00000025671	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Retinoic acid receptor beta-like.	0.692
MED1	RARG	ENSUMAP00000023808	ENSUMAP00000013552	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Retinoic acid receptor gamma isoform X1.	0.740
PITX1	TBX4	ENSUMAP00000023844	ENSUMAP00000030834	Homeobox protein.	LOW QUALITY PROTEIN: T-box transcription factor TBX4.	0.533
RARB	MED1	ENSUMAP00000025671	ENSUMAP00000023808	Retinoic acid receptor beta-like.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.692
RARG	MED1	ENSUMAP00000013552	ENSUMAP00000023808	Retinoic acid receptor gamma isoform X1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.740
TBX3	BMP4	ENSUMAP00000014725	ENSUMAP00000021648	LOW QUALITY PROTEIN: T-box transcription factor TBX3.	Bone morphogenetic protein 4.	0.483
TBX4	PITX1	ENSUMAP00000030834	ENSUMAP00000023844	LOW QUALITY PROTEIN: T-box transcription factor TBX4.	Homeobox protein.	0.533