(18 nodes) Aorta morphogenesis network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUMAP00000031149	annotation not available (164 aa)
	ENG	Endoglin. (609 aa)
	SEC24B	Protein transport protein Sec24B. (1144 aa)
	HES1	Transcription factor HES-1. (166 aa)
	TFAP2B	Transcription factor AP-2-beta. (460 aa)
	TFAP2E	Transcription factor AP-2-epsilon. (416 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	SRF	Serum response factor. (446 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
	CHD7	chromodomain-helicase-DNA-binding protein 7. (2976 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	PROX1	Prospero homeobox protein 1. (737 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
	ENSUMAP00000025747	annotation not available (76 aa)
	COL3A1	Collagen alpha-1(III) chain. (762 aa)
	FOXH1	Forkhead box protein H1 isoform X1. (370 aa)
	NPRL3	Nitrogen permease regulator 3-like protein isoform X2. (594 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMPR1A	ENSUMAP00000011741	ENSUMAP00000019489	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.405
ACVRL1	ENG	ENSUMAP00000011741	ENSUMAP00000000344	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.717
BMPR1A	ACVRL1	ENSUMAP00000019489	ENSUMAP00000011741	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.405
DLL4	HES1	ENSUMAP00000016887	ENSUMAP00000000894	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transcription factor HES-1.	0.565
DLL4	JAG1	ENSUMAP00000016887	ENSUMAP00000011268	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.435
ENG	ACVRL1	ENSUMAP00000000344	ENSUMAP00000011741	Endoglin.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.717
ENSUMAP00000025747	JAG1	ENSUMAP00000025747	ENSUMAP00000011268	annotation not available	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.449
EYA1	JAG1	ENSUMAP00000025735	ENSUMAP00000011268	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.449
HES1	DLL4	ENSUMAP00000000894	ENSUMAP00000016887	Transcription factor HES-1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.565
HES1	JAG1	ENSUMAP00000000894	ENSUMAP00000011268	Transcription factor HES-1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.636
JAG1	DLL4	ENSUMAP00000011268	ENSUMAP00000016887	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.435
JAG1	ENSUMAP00000025747	ENSUMAP00000011268	ENSUMAP00000025747	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	annotation not available	0.449
JAG1	EYA1	ENSUMAP00000011268	ENSUMAP00000025735	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.449
JAG1	HES1	ENSUMAP00000011268	ENSUMAP00000000894	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transcription factor HES-1.	0.636