(33 nodes) Cellular response to vascular endothelial growth factor stimulus network (Ursus maritimus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAPKAPK2	MAP kinase-activated protein kinase 2. (349 aa)
	FLT4	Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1344 aa)
	VEGFB	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (167 aa)
	PLCG1	Phosphoinositide phospholipase C. (1178 aa)
	DAB2IP	Disabled homolog 2-interacting protein. (877 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	EGR3	Early growth response protein 3. (335 aa)
	MAP2K3	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (179 aa)
	KDR	LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1344 aa)
	PRKD1	Serine/threonine-protein kinase D1. (874 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	ENSUMAP00000010977	annotation not available (77 aa)
	PGF	Placenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (156 aa)
	MYO1C	LOW QUALITY PROTEIN: unconventional myosin-Ic; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1009 aa)
	RELA	Transcription factor p65. (585 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
	HSPB1	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (290 aa)
	SPHK1	LOW QUALITY PROTEIN: sphingosine kinase 1. (387 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	GAB1	GRB2-associated-binding protein 1. (722 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	ENSUMAP00000023341	annotation not available (433 aa)
	FLT1	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (645 aa)
	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1. (1029 aa)
	SEMA6A	LOW QUALITY PROTEIN: semaphorin-6A; Belongs to the semaphorin family. (1028 aa)
	SHC1	LOW QUALITY PROTEIN: SHC-transforming protein 1. (569 aa)
	ANXA1	Annexin. (345 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (926 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (436 aa)
	PRKD2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (833 aa)
	PIK3CD	LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (855 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAB2IP	ERN1	ENSUMAP00000004381	ENSUMAP00000024216	Disabled homolog 2-interacting protein.	Serine/threonine-protein kinase/endoribonuclease IRE1.	0.495
DLL4	FLT4	ENSUMAP00000016887	ENSUMAP00000034177	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.404
DLL4	VEGFC	ENSUMAP00000016887	ENSUMAP00000032472	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.649
ENSUMAP00000010977	ENSUMAP00000023341	ENSUMAP00000010977	ENSUMAP00000023341	annotation not available	annotation not available	0.732
ENSUMAP00000010977	FLT1	ENSUMAP00000010977	ENSUMAP00000023353	annotation not available	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.732
ENSUMAP00000010977	FLT4	ENSUMAP00000010977	ENSUMAP00000034177	annotation not available	Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.552
ENSUMAP00000010977	KDR	ENSUMAP00000010977	ENSUMAP00000007771	annotation not available	LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.753
ENSUMAP00000010977	NRP1	ENSUMAP00000010977	ENSUMAP00000021983	annotation not available	Neuropilin; Belongs to the neuropilin family.	0.649
ENSUMAP00000010977	NRP2	ENSUMAP00000010977	ENSUMAP00000031095	annotation not available	Neuropilin; Belongs to the neuropilin family.	0.453
ENSUMAP00000010977	PDGFRA	ENSUMAP00000010977	ENSUMAP00000004437	annotation not available	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.526
ENSUMAP00000010977	VEGFA	ENSUMAP00000010977	ENSUMAP00000007668	annotation not available	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family.	0.436
ENSUMAP00000010977	VEGFB	ENSUMAP00000010977	ENSUMAP00000001538	annotation not available	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family.	0.592
ENSUMAP00000010977	VEGFC	ENSUMAP00000010977	ENSUMAP00000032472	annotation not available	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.455
ENSUMAP00000023341	ENSUMAP00000010977	ENSUMAP00000023341	ENSUMAP00000010977	annotation not available	annotation not available	0.732
ENSUMAP00000023341	FLT1	ENSUMAP00000023341	ENSUMAP00000023353	annotation not available	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.900
ENSUMAP00000023341	KDR	ENSUMAP00000023341	ENSUMAP00000007771	annotation not available	LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.468
ENSUMAP00000023341	MAPKAPK2	ENSUMAP00000023341	ENSUMAP00000035267	annotation not available	MAP kinase-activated protein kinase 2.	0.581
ENSUMAP00000023341	NRP1	ENSUMAP00000023341	ENSUMAP00000021983	annotation not available	Neuropilin; Belongs to the neuropilin family.	0.711
ENSUMAP00000023341	NRP2	ENSUMAP00000023341	ENSUMAP00000031095	annotation not available	Neuropilin; Belongs to the neuropilin family.	0.831
ENSUMAP00000023341	PGF	ENSUMAP00000023341	ENSUMAP00000010978	annotation not available	Placenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.732