(15 nodes) Response to muscle stretch network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLC8A1	Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (622 aa)
	ANKRD1	Ankyrin repeat domain-containing protein 1. (319 aa)
	GSN	Gelsolin isoform X1. (748 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	SLC8A3	LOW QUALITY PROTEIN: sodium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (893 aa)
	RELA	Transcription factor p65. (585 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (253 aa)
	ANKRD23	Ankyrin repeat domain-containing protein 23 isoform X1. (428 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (813 aa)
	RYR2	Ryanodine receptor 2. (4923 aa)
	TCAP	Telethonin. (167 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	CSRP3	Cysteine and glycine-rich protein 3. (194 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD1	TCAP	ENSUMAP00000000980	ENSUMAP00000023987	Ankyrin repeat domain-containing protein 1.	Telethonin.	0.488
CAV3	CSRP3	ENSUMAP00000026521	ENSUMAP00000028045	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Cysteine and glycine-rich protein 3.	0.573
CAV3	RYR2	ENSUMAP00000026521	ENSUMAP00000017715	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Ryanodine receptor 2.	0.577
CSRP3	CAV3	ENSUMAP00000028045	ENSUMAP00000026521	Cysteine and glycine-rich protein 3.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.573
CSRP3	TCAP	ENSUMAP00000028045	ENSUMAP00000023987	Cysteine and glycine-rich protein 3.	Telethonin.	0.698
FOS	NFKBIA	ENSUMAP00000010310	ENSUMAP00000015252	Fos proto-oncogene, AP-1 transcription factor subunit.	NF-kappa-B inhibitor alpha.	0.610
FOS	RELA	ENSUMAP00000010310	ENSUMAP00000014520	Fos proto-oncogene, AP-1 transcription factor subunit.	Transcription factor p65.	0.538
NFKBIA	FOS	ENSUMAP00000015252	ENSUMAP00000010310	NF-kappa-B inhibitor alpha.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.610
NFKBIA	RELA	ENSUMAP00000015252	ENSUMAP00000014520	NF-kappa-B inhibitor alpha.	Transcription factor p65.	0.999
PIK3CA	RAF1	ENSUMAP00000010426	ENSUMAP00000024161	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	RAF proto-oncogene serine/threonine-protein kinase.	0.950
RAF1	PIK3CA	ENSUMAP00000024161	ENSUMAP00000010426	RAF proto-oncogene serine/threonine-protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.950
RAF1	RELA	ENSUMAP00000024161	ENSUMAP00000014520	RAF proto-oncogene serine/threonine-protein kinase.	Transcription factor p65.	0.934
RELA	FOS	ENSUMAP00000014520	ENSUMAP00000010310	Transcription factor p65.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.538
RELA	NFKBIA	ENSUMAP00000014520	ENSUMAP00000015252	Transcription factor p65.	NF-kappa-B inhibitor alpha.	0.999
RELA	RAF1	ENSUMAP00000014520	ENSUMAP00000024161	Transcription factor p65.	RAF proto-oncogene serine/threonine-protein kinase.	0.934
RYR2	CAV3	ENSUMAP00000017715	ENSUMAP00000026521	Ryanodine receptor 2.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.577
RYR2	SLC8A1	ENSUMAP00000017715	ENSUMAP00000018020	Ryanodine receptor 2.	Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.483
RYR2	SLC8A3	ENSUMAP00000017715	ENSUMAP00000013155	Ryanodine receptor 2.	LOW QUALITY PROTEIN: sodium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.483
SLC8A1	RYR2	ENSUMAP00000018020	ENSUMAP00000017715	Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Ryanodine receptor 2.	0.483
SLC8A1	SLC8A3	ENSUMAP00000018020	ENSUMAP00000013155	Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	LOW QUALITY PROTEIN: sodium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.901