STRINGSTRING
ENSUMAP00000020575 ENSUMAP00000020575 IL20RB IL20RB CLEC4G CLEC4G SHH SHH PYCARD PYCARD DLG5 DLG5 BMI1 BMI1 ENSUMAP00000018377 ENSUMAP00000018377 LGALS9 LGALS9 SOS1 SOS1 PTPN22 PTPN22 BTNL2 BTNL2 LOC103665509 LOC103665509 ZP3 ZP3 ZP4 ZP4 PRKCQ PRKCQ PTEN PTEN IL2RA IL2RA CD6 CD6 NDFIP1 NDFIP1 LOC103668179 LOC103668179 NCKAP1L NCKAP1L GLMN GLMN TNFSF9 TNFSF9 CORO1A CORO1A IL27 IL27 RPS3 RPS3 ARG2 ARG2 TNFRSF14 TNFRSF14 CD40LG CD40LG AGER AGER IL12RB1 IL12RB1 IL6ST IL6ST VSIR VSIR TMIGD2 TMIGD2 CARD11 CARD11 SOS2 SOS2 MARCHF7 MARCHF7 FADD FADD MAD1L1 MAD1L1 DHPS DHPS FOXP3 FOXP3 IL18 IL18 IL12RB2 IL12RB2 CD81 CD81 TSPAN32 TSPAN32 LEP LEP PRKAR1B PRKAR1B CBLB CBLB ITCH ITCH HHLA2 HHLA2 PPP3CA PPP3CA TNFRSF21 TNFRSF21 VTCN1 VTCN1 SASH3 SASH3 IL21 IL21 IL27RA IL27RA IL2 IL2 SPTA1 SPTA1 LRRC1 LRRC1 PTPN6 PTPN6 BCL6 BCL6 TFRC TFRC DLG1 DLG1 KITLG KITLG CD3E CD3E RASAL3 RASAL3 ENSUMAP00000001615 ENSUMAP00000001615 EFNB1 EFNB1 PRKAR1A PRKAR1A HES1 HES1 SCRIB SCRIB IL12B IL12B ENSUMAP00000000296 ENSUMAP00000000296 GPNMB GPNMB SLAMF1 SLAMF1 IDO1 IDO1 PTPRC PTPRC CD80 CD80 CD86 CD86 TYK2 TYK2 STAT5A STAT5A TNFRSF9 TNFRSF9 DLG2 DLG2 GPAM GPAM STAT5B STAT5B RIPK3 RIPK3 TNFSF13B TNFSF13B CRTAM CRTAM CTLA4 CTLA4 CD28 CD28 TNFRSF1B TNFRSF1B ANXA1 ANXA1 ENSUMAP00000029099 ENSUMAP00000029099 PELI1 PELI1 NCK2 NCK2 SH3RF1 SH3RF1 IGFBP2 IGFBP2 RC3H1 RC3H1 TNFSF4 TNFSF4 TNFSF18 TNFSF18 LOC103679897 LOC103679897 IHH IHH PLA2G2D PLA2G2D PLA2G2F PLA2G2F TWSG1 TWSG1 IRF1 IRF1 TRAF6 TRAF6 HMGB1 HMGB1 SLC7A1 SLC7A1 VSIG4 VSIG4 IL23A IL23A CD274 CD274 PDCD1LG2 PDCD1LG2 SYK SYK TMEM131L TMEM131L LGALS3 LGALS3 BMP4 BMP4 RAC2 RAC2 RIPK2 RIPK2 IL15 IL15 AIF1 AIF1 NCK1 NCK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUMAP00000020575annotation not available (177 aa)
IL20RBInterleukin-20 receptor subunit beta isoform X2. (392 aa)
CLEC4GC-type lectin domain family 4 member G. (312 aa)
SHHSonic hedgehog protein. (168 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
DLG5Disks large homolog 5; Belongs to the MAGUK family. (1852 aa)
BMI1Polycomb complex protein BMI-1. (326 aa)
ENSUMAP00000018377annotation not available (92 aa)
LGALS9Galectin. (355 aa)
SOS1Son of sevenless homolog 1. (1276 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X2. (806 aa)
BTNL2Butyrophilin-like protein 2. (147 aa)
LOC103665509HLA class II histocompatibility antigen, DM beta chain. (280 aa)
ZP3Zona pellucida sperm-binding protein 3. (426 aa)
ZP4Zona pellucida sperm-binding protein 4. (568 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
IL2RAInterleukin-2 receptor subunit alpha isoform X1. (267 aa)
CD6T-cell differentiation antigen CD6. (613 aa)
NDFIP1NEDD4 family-interacting protein 1. (203 aa)
LOC103668179LOW QUALITY PROTEIN: high mobility group protein B1-like. (200 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
GLMNGlomulin, FKBP associated protein. (600 aa)
TNFSF9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (212 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
IL27Interleukin-27 subunit alpha. (236 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
ARG2Arginase. (354 aa)
TNFRSF14Tumor necrosis factor receptor superfamily member 14 isoform X1. (350 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
AGERAdvanced glycosylation end product-specific receptor. (311 aa)
IL12RB1LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1. (724 aa)
IL6STInterleukin-6 receptor subunit beta isoform X1. (918 aa)
VSIRPlatelet receptor Gi24. (252 aa)
TMIGD2Transmembrane and immunoglobulin domain-containing protein 2. (155 aa)
CARD11Caspase recruitment domain-containing protein 11. (1215 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1272 aa)
MARCHF7E3 ubiquitin-protein ligase MARCH7 isoform X1. (708 aa)
FADDFAS-associated death domain protein. (192 aa)
MAD1L1LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD1. (706 aa)
DHPSDeoxyhypusine synthase. (369 aa)
FOXP3Forkhead box protein P3. (314 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (217 aa)
IL12RB2Interleukin-12 receptor subunit beta-2. (862 aa)
CD81Tetraspanin. (429 aa)
TSPAN32Tetraspanin-32; Belongs to the tetraspanin (TM4SF) family. (210 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
PRKAR1BLOW QUALITY PROTEIN: cAMP-dependent protein kinase type I-beta regulatory subunit. (412 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (983 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
HHLA2HERV-H LTR-associating protein 2. (395 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
TNFRSF21Tumor necrosis factor receptor superfamily member 21. (637 aa)
VTCN1V-set domain-containing T-cell activation inhibitor 1. (275 aa)
SASH3SAM and SH3 domain-containing protein 3. (321 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
IL27RAInterleukin-27 receptor subunit alpha. (636 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
SPTA1LOW QUALITY PROTEIN: spectrin alpha chain, erythrocytic 1. (2388 aa)
LRRC1Leucine-rich repeat-containing protein 1. (493 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
BCL6B-cell lymphoma 6 protein isoform X1. (706 aa)
TFRCTransferrin receptor protein 1 isoform X1. (770 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
KITLGKit ligand. (274 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (201 aa)
RASAL3RAS protein activator like-3. (879 aa)
ENSUMAP00000001615annotation not available (131 aa)
EFNB1ephrin-B1; Belongs to the ephrin family. (418 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (409 aa)
HES1Transcription factor HES-1. (166 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (844 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
ENSUMAP00000000296annotation not available (97 aa)
GPNMBTransmembrane glycoprotein NMB isoform X1. (555 aa)
SLAMF1Signaling lymphocytic activation molecule isoform X2. (338 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (389 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1268 aa)
CD80T-lymphocyte activation antigen CD80. (302 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (343 aa)
TYK2Tyrosine-protein kinase. (1043 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
TNFRSF9Tumor necrosis factor receptor superfamily member 9 isoform X2. (246 aa)
DLG2Disks large homolog 2 isoform X1. (843 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (840 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
RIPK3Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. (487 aa)
TNFSF13BTumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (293 aa)
CRTAMCytotoxic and regulatory T-cell molecule isoform X1. (391 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
CD28T-cell-specific surface glycoprotein CD28. (277 aa)
TNFRSF1BLOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1B. (313 aa)
ANXA1Annexin. (345 aa)
ENSUMAP00000029099annotation not available (138 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
NCK2Cytoplasmic protein. (380 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1. (869 aa)
IGFBP2Insulin-like growth factor-binding protein 2. (228 aa)
RC3H1Ring finger and CCCH-type domains 1. (1133 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
TNFSF18Tumor necrosis factor ligand superfamily member 18. (178 aa)
LOC103679897Galectin. (158 aa)
IHHIndian hedgehog protein. (145 aa)
PLA2G2DPhospholipase A(2). (161 aa)
PLA2G2FPhospholipase A(2). (199 aa)
TWSG1Twisted gastrulation protein homolog 1. (202 aa)
IRF1Interferon regulatory factor. (338 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
HMGB1High mobility group protein B1. (215 aa)
SLC7A1High affinity cationic amino acid transporter 1. (629 aa)
VSIG4V-set and immunoglobulin domain-containing protein 4 isoform X2. (385 aa)
IL23AInterleukin-23 subunit alpha. (190 aa)
CD274Programmed cell death 1 ligand 1. (291 aa)
PDCD1LG2LOW QUALITY PROTEIN: programmed cell death 1 ligand 2. (236 aa)
SYKTyrosine-protein kinase SYK; Belongs to the protein kinase superfamily. Tyr protein kinase family. (610 aa)
TMEM131LTransmembrane protein 131-like. (1545 aa)
LGALS3Galectin. (282 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (231 aa)
RIPK2LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2. (512 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
AIF1Leukocyte-specific transcript 1 protein. (191 aa)
NCK1NCK adaptor protein 1. (244 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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