STRINGSTRING
HDAC3 HDAC3 HCLS1 HCLS1 IPO5 IPO5 DMAP1 DMAP1 TARDBP TARDBP JUP JUP TPR TPR IFNG IFNG FLNA FLNA UBR5 UBR5 PTPN22 PTPN22 GLI3 GLI3 PIK3R2 PIK3R2 CHP2 CHP2 EFCAB7 EFCAB7 PIK3R1 PIK3R1 ECT2 ECT2 ENSUMAP00000010661 ENSUMAP00000010661 SMO SMO PRKD1 PRKD1 LOC103677394 LOC103677394 ENSUMAP00000006580 ENSUMAP00000006580 MAVS MAVS TRIM28 TRIM28 ZPR1 ZPR1 RBM22 RBM22 BAG3 BAG3 ZC3H12A ZC3H12A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
HCLS1Hematopoietic lineage cell-specific protein. (510 aa)
IPO5Importin-5. (1037 aa)
DMAP1DNA methyltransferase 1-associated protein 1. (435 aa)
TARDBPTAR DNA-binding protein 43. (292 aa)
JUPJunction plakoglobin. (716 aa)
TPRNucleoprotein TPR. (2425 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
FLNAfilamin-A. (2549 aa)
UBR5LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UBR5. (2732 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X2. (806 aa)
GLI3Transcriptional activator GLI3. (524 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
CHP2Calcineurin B homologous protein 2. (208 aa)
EFCAB7EF-hand calcium-binding domain-containing protein 7. (629 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
ECT2Protein ECT2. (641 aa)
ENSUMAP00000010661annotation not available (263 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (745 aa)
PRKD1Serine/threonine-protein kinase D1. (874 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
ENSUMAP00000006580annotation not available (238 aa)
MAVSLOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein. (710 aa)
TRIM28Transcription intermediary factor 1-beta. (821 aa)
ZPR1Zinc finger protein ZPR1. (477 aa)
RBM22pre-mRNA-splicing factor RBM22. (420 aa)
BAG3BAG family molecular chaperone regulator 3. (551 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (18%) [HD]