STRINGSTRING
INSIG1 INSIG1 GJB6 GJB6 SIX1 SIX1 ENSUMAP00000018722 ENSUMAP00000018722 CHD7 CHD7 SLC44A4 SLC44A4 INSIG2 INSIG2 PLS1 PLS1 GRHL3 GRHL3 SIX2 SIX2 CLRN1 CLRN1 NIPBL NIPBL MAPK3 MAPK3 TBX3 TBX3 GRXCR2 GRXCR2 LHFPL5 LHFPL5 PTK7 PTK7 STRC STRC USH1G USH1G ENSUMAP00000010835 ENSUMAP00000010835 TSHR TSHR WHRN WHRN WNT1 WNT1 FGF10 FGF10 FOXG1 FOXG1 TSHZ1 TSHZ1 TMIE TMIE PTPRQ PTPRQ LRRC1 LRRC1 MAPK1 MAPK1 CLRN2 CLRN2 LOC103682075 LOC103682075 BCR BCR CHRNA9 CHRNA9 KCNQ4 KCNQ4 WDR19 WDR19 SEC24B SEC24B SCRIB SCRIB ALDH1A3 ALDH1A3 FOXI1 FOXI1 LRIG1 LRIG1 USH1C USH1C OSR1 OSR1 TPRN TPRN PDZD7 PDZD7 PDZD7-2 PDZD7-2 FZD3 FZD3 ATP6V1B1 ATP6V1B1 ENSUMAP00000029735 ENSUMAP00000029735 DLX5 DLX5 DLX6 DLX6 KCNQ1 KCNQ1 TTC39C TTC39C WDPCP WDPCP ENSUMAP00000028342 ENSUMAP00000028342 RIPOR2 RIPOR2 LRIG3 LRIG3 SOBP SOBP CTHRC1 CTHRC1 HESX1 HESX1 ENSUMAP00000025747 ENSUMAP00000025747 EYA1 EYA1 HPN HPN BLOC1S5 BLOC1S5 TFAP2A TFAP2A EDN1 EDN1 TCAP TCAP TIFAB TIFAB FRZB FRZB OSR2 OSR2 PRKRA PRKRA ZEB1 ZEB1 EDNRA EDNRA MYO6 MYO6 DVL2 DVL2 FGF9 FGF9 SPRY2 SPRY2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (247 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
SIX1Homeobox protein SIX1. (284 aa)
ENSUMAP00000018722annotation not available (372 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2976 aa)
SLC44A4Choline transporter-like protein 4; Belongs to the CTL (choline transporter-like) family. (707 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (229 aa)
PLS1Plastin-1 isoform X1. (629 aa)
GRHL3Grainyhead-like protein 3 homolog isoform X1. (700 aa)
SIX2LOW QUALITY PROTEIN: homeobox protein SIX2. (267 aa)
CLRN1Clarin-1. (232 aa)
NIPBLNipped-B protein. (2805 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (130 aa)
GRXCR2Glutaredoxin domain-containing cysteine-rich protein 2. (248 aa)
LHFPL5Tetraspan membrane protein of hair cell stereocilia. (237 aa)
PTK7Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
STRCStereocilin. (1765 aa)
USH1GUsher syndrome type-1G protein. (236 aa)
ENSUMAP00000010835annotation not available (213 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (756 aa)
WHRNWhirlin. (798 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (334 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
FOXG1Forkhead box protein G1. (221 aa)
TSHZ1LOW QUALITY PROTEIN: teashirt homolog 1. (1052 aa)
TMIETransmembrane inner ear expressed protein. (166 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2318 aa)
LRRC1Leucine-rich repeat-containing protein 1. (493 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
CLRN2Clarin-2. (232 aa)
LOC103682075Segment polarity protein dishevelled homolog DVL-1-like. (893 aa)
BCRBCR activator of RhoGEF and GTPase. (1162 aa)
CHRNA9Neuronal acetylcholine receptor subunit alpha-9. (478 aa)
KCNQ4Potassium voltage-gated channel subfamily KQT member 4. (262 aa)
WDR19WD repeat-containing protein 19. (1283 aa)
SEC24BProtein transport protein Sec24B. (1144 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (844 aa)
ALDH1A3Aldehyde dehydrogenase family 1 member A3; Belongs to the aldehyde dehydrogenase family. (555 aa)
FOXI1Forkhead box protein I1 isoform X1. (378 aa)
LRIG1Leucine-rich repeats and immunoglobulin-like domains protein 1. (1026 aa)
USH1CLOW QUALITY PROTEIN: harmonin. (853 aa)
OSR1Protein odd-skipped-related 1. (272 aa)
TPRNTaperin. (409 aa)
PDZD7LOW QUALITY PROTEIN: PDZ domain-containing protein 7. (538 aa)
PDZD7-2PDZ domain-containing protein 7. (154 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (509 aa)
ENSUMAP00000029735annotation not available (98 aa)
DLX5Homeobox protein DLX-5. (285 aa)
DLX6Homeobox protein DLX-6. (167 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (410 aa)
TTC39CTetratricopeptide repeat protein 39C. (522 aa)
WDPCPLOW QUALITY PROTEIN: WD repeat-containing and planar cell polarity effector protein fritz homolog. (690 aa)
ENSUMAP00000028342annotation not available (97 aa)
RIPOR2Protein FAM65B. (974 aa)
LRIG3Leucine-rich repeats and immunoglobulin-like domains protein 3. (1026 aa)
SOBPSine oculis-binding protein homolog. (577 aa)
CTHRC1LOW QUALITY PROTEIN: collagen triple helix repeat-containing protein 1. (113 aa)
HESX1Homeobox expressed in ES cells 1. (181 aa)
ENSUMAP00000025747annotation not available (76 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
HPNSerine protease hepsin; Belongs to the peptidase S1 family. (237 aa)
BLOC1S5Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (191 aa)
TFAP2ALOW QUALITY PROTEIN: transcription factor AP-2-alpha. (494 aa)
EDN1Endothelin-1. (202 aa)
TCAPTelethonin. (167 aa)
TIFABTRAF-interacting protein with FHA domain-containing protein B. (201 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
PRKRAInterferon-inducible double-stranded RNA-dependent protein kinase activator A. (288 aa)
ZEB1Zinc finger E-box-binding homeobox 1. (1086 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
MYO6Unconventional myosin-VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1245 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (391 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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