STRINGSTRING
TIFA TIFA NR1H4 NR1H4 AKAP13 AKAP13 EDA EDA NLRC3 NLRC3 ZC3H12A ZC3H12A RBCK1 RBCK1 TRIM25 TRIM25 SPHK2 SPHK2 NLRX1 NLRX1 TLR4 TLR4 ADIPOQ ADIPOQ IKBKE IKBKE TRAF1 TRAF1 CD74 CD74 LITAF LITAF TNIP3 TNIP3 OTUD7B OTUD7B DHX15 DHX15 TNIP1 TNIP1 DAB2IP DAB2IP CLEC4D CLEC4D CLEC6A CLEC6A TAB2 TAB2 CAPN3 CAPN3 CAPN3-2 CAPN3-2 ENSUMAP00000015030 ENSUMAP00000015030 TRIM59 TRIM59 NLRP12 NLRP12 ENSUMAP00000015418 ENSUMAP00000015418 ENSUMAP00000015424 ENSUMAP00000015424 MAPKBP1 MAPKBP1 PARK2 PARK2 TRAF4 TRAF4 ENSUMAP00000015922 ENSUMAP00000015922 PARK2-2 PARK2-2 ZFAND6 ZFAND6 NUP62CL NUP62CL RELA RELA TRIML2 TRIML2 TRIML1 TRIML1 MID2 MID2 ENSUMAP00000014414 ENSUMAP00000014414 ENSUMAP00000013971 ENSUMAP00000013971 ENSUMAP00000013687 ENSUMAP00000013687 ZMYND11 ZMYND11 BTNL9 BTNL9 LOC103659111 LOC103659111 PRKCB PRKCB ROR1 ROR1 TANK TANK LOC103665935 LOC103665935 TRIM62 TRIM62 TNFSF10 TNFSF10 DDX21 DDX21 DDX50 DDX50 USP10 USP10 CARD11 CARD11 TNFRSF1A TNFRSF1A LTBR LTBR CACTIN CACTIN SIRT1 SIRT1 WDR83 WDR83 FADD FADD TNIP2 TNIP2 PRKD1 PRKD1 CTH CTH ANKRD17 ANKRD17 CCL21 CCL21 CCL19 CCL19 TRAF3 TRAF3 NOD2 NOD2 PIDD1 PIDD1 MYD88 MYD88 TRIM21 TRIM21 TRIM68 TRIM68 CAPN9 CAPN9 NLRP6 NLRP6 F2RL1 F2RL1 CD4 CD4 LTF LTF TRIM32 TRIM32 CPNE1 CPNE1 DHX36 DHX36 TREM2 TREM2 TREML1 TREML1 UNC5CL UNC5CL TLR3 TLR3 MAP3K7 MAP3K7 HSPB1 HSPB1 PPM1B PPM1B ENSUMAP00000017592 ENSUMAP00000017592 PRKCE PRKCE TMEM101 TMEM101 OPTN OPTN PPM1A PPM1A AJUBA AJUBA PYCARD PYCARD TERF2IP TERF2IP TAB3 TAB3 TNF TNF TNFRSF19 TNFRSF19 MAP3K14 MAP3K14 PLCG2 PLCG2 RIPK2 RIPK2 LOC103667265 LOC103667265 RHOC RHOC TNFSF11 TNFSF11 CLEC7A CLEC7A MTDH MTDH HTR2B HTR2B EDA2R EDA2R MAP3K3 MAP3K3 TRAF6 TRAF6 ATP2C1 ATP2C1 NR1D1 NR1D1 LPAR1 LPAR1 TRIM13 TRIM13 ABL1 ABL1 RIPK1 RIPK1 PINK1 PINK1 TRIM39-RPP21 TRIM39-RPP21 UBD UBD REL REL NFKBIB NFKBIB IKBKG IKBKG TRIM27 TRIM27 ENSUMAP00000026718 ENSUMAP00000026718 ASH1L ASH1L TRIM61 TRIM61 LOC103658131 LOC103658131 LOC103658124 LOC103658124 LOC103658125 LOC103658125 LURAP1L LURAP1L FASLG FASLG RIOK3 RIOK3 TRADD TRADD STAT1 STAT1 TBK1 TBK1 S100A13 S100A13 S100A12 S100A12 SHARPIN SHARPIN TRIM38 TRIM38 EDAR EDAR PELI1 PELI1 TRAF5 TRAF5 LOC103656900 LOC103656900 PPM1M PPM1M CFLAR CFLAR CASP10 CASP10 CASP8 CASP8 UFL1 UFL1 LIME1 LIME1 ENSUMAP00000031254 ENSUMAP00000031254 RNF31 RNF31 CHUK CHUK RHOA RHOA PDPK1 PDPK1 NKIRAS2 NKIRAS2 BTRC BTRC TRAF2 TRAF2 OTUD7A OTUD7A DDX1 DDX1 TRIM8 TRIM8 PPM1N PPM1N LURAP1 LURAP1 TLE1 TLE1 TNFAIP3 TNFAIP3 RORA RORA IRAK4 IRAK4 SQSTM1 SQSTM1 ENSUMAP00000033644 ENSUMAP00000033644 LOC103669669-2 LOC103669669-2 TRIM22 TRIM22 LOC103680048 LOC103680048 LOC103680046 LOC103680046 S100B S100B TMEM106A TMEM106A TRAF3IP2 TRAF3IP2 IKBKB IKBKB LOC103677095 LOC103677095 C18orf32 C18orf32 TIRAP TIRAP BCL10 BCL10 ALPK1 ALPK1 ESR1 ESR1 ENSUMAP00000002447 ENSUMAP00000002447 NOD1 NOD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIFATRAF-interacting protein with FHA domain-containing protein A. (168 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
AKAP13A-kinase anchor protein 13. (2651 aa)
EDAectodysplasin-A; Belongs to the tumor necrosis factor family. (242 aa)
NLRC3Protein NLRC3. (1085 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
RBCK1ranBP-type and C3HC4-type zinc finger-containing protein 1. (521 aa)
TRIM25E3 ubiquitin/ISG15 ligase TRIM25. (490 aa)
SPHK2Sphingosine kinase 2. (417 aa)
NLRX1NLR family member X1. (1463 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
ADIPOQAdiponectin isoform X2. (297 aa)
IKBKELOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon. (692 aa)
TRAF1TNF receptor-associated factor. (408 aa)
CD74LOW QUALITY PROTEIN: HLA class II histocompatibility antigen gamma chain. (279 aa)
LITAFLipopolysaccharide-induced tumor necrosis factor-alpha factor. (161 aa)
TNIP3TNFAIP3-interacting protein 3. (365 aa)
OTUD7BOTU domain-containing protein 7B isoform X1. (844 aa)
DHX15Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15. (728 aa)
TNIP1TNFAIP3-interacting protein 1 isoform X1. (639 aa)
DAB2IPDisabled homolog 2-interacting protein. (877 aa)
CLEC4DC-type lectin domain family 4 member D. (211 aa)
CLEC6ALOW QUALITY PROTEIN: C-type lectin domain family 6 member A. (231 aa)
TAB2LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (670 aa)
CAPN3Calpain-3 isoform X8; Belongs to the peptidase C2 family. (202 aa)
CAPN3-2Calpain-3 isoform X2; Belongs to the peptidase C2 family. (493 aa)
ENSUMAP00000015030annotation not available (82 aa)
TRIM59Tripartite motif-containing protein 59. (403 aa)
NLRP12NACHT, LRR and PYD domains-containing protein 12. (552 aa)
ENSUMAP00000015418annotation not available (242 aa)
ENSUMAP00000015424annotation not available (80 aa)
MAPKBP1Mitogen-activated protein kinase-binding protein 1. (1346 aa)
PARK2E3 ubiquitin-protein ligase parkin isoform X5. (153 aa)
TRAF4TNF receptor-associated factor. (435 aa)
ENSUMAP00000015922annotation not available (110 aa)
PARK2-2E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (176 aa)
ZFAND6AN1-type zinc finger protein 6 isoform X4. (208 aa)
NUP62CLNucleoporin-62 C-terminal-like protein isoform X1. (184 aa)
RELATranscription factor p65. (585 aa)
TRIML2Probable E3 ubiquitin-protein ligase TRIML2. (355 aa)
TRIML1Probable E3 ubiquitin-protein ligase TRIML1. (474 aa)
MID2Probable E3 ubiquitin-protein ligase MID2. (676 aa)
ENSUMAP00000014414annotation not available (310 aa)
ENSUMAP00000013971annotation not available (193 aa)
ENSUMAP00000013687annotation not available (97 aa)
ZMYND11Zinc finger MYND domain-containing protein 11 isoform X1. (602 aa)
BTNL9LOW QUALITY PROTEIN: butyrophilin-like protein 9. (155 aa)
LOC103659111LOW QUALITY PROTEIN: coiled-coil domain-containing protein 22-like. (621 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
ROR1Tyrosine-protein kinase transmembrane receptor ROR1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (983 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X2. (426 aa)
LOC103665935Uncharacterized protein LOC103665935. (80 aa)
TRIM62LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIM62. (285 aa)
TNFSF10Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (286 aa)
DDX21Nucleolar RNA helicase 2. (794 aa)
DDX50ATP-dependent RNA helicase DDX50 isoform X1. (739 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (802 aa)
CARD11Caspase recruitment domain-containing protein 11. (1215 aa)
TNFRSF1ALOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A. (507 aa)
LTBRTumor necrosis factor receptor superfamily member 3 isoform X2. (421 aa)
CACTINCactin. (189 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X2. (446 aa)
WDR83WD repeat domain-containing protein 83. (315 aa)
FADDFAS-associated death domain protein. (192 aa)
TNIP2TNFAIP3 interacting protein 2. (329 aa)
PRKD1Serine/threonine-protein kinase D1. (874 aa)
CTHCystathionine gamma-lyase. (405 aa)
ANKRD17LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 17. (2527 aa)
CCL21C-C motif chemokine ligand 21. (137 aa)
CCL19C-C motif chemokine. (115 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (817 aa)
PIDD1LOW QUALITY PROTEIN: p53-induced death domain-containing protein 1. (844 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
TRIM21E3 ubiquitin-protein ligase TRIM21. (469 aa)
TRIM68E3 ubiquitin-protein ligase TRIM68. (485 aa)
CAPN9Calpain-9 isoform X1; Belongs to the peptidase C2 family. (669 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (795 aa)
F2RL1Proteinase-activated receptor 2. (399 aa)
CD4T-cell surface glycoprotein CD4. (460 aa)
LTFLactotransferrin; Belongs to the transferrin family. (708 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32. (654 aa)
CPNE1Copine-1. (537 aa)
DHX36ATP-dependent RNA helicase DHX36. (1011 aa)
TREM2Triggering receptor expressed on myeloid cells 2 isoform X2. (322 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (313 aa)
UNC5CLLOW QUALITY PROTEIN: UNC5C-like protein. (492 aa)
TLR3Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family. (905 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (290 aa)
PPM1BProtein phosphatase 1B isoform X1. (479 aa)
ENSUMAP00000017592annotation not available (120 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (226 aa)
TMEM101Transmembrane protein 101. (257 aa)
OPTNLOW QUALITY PROTEIN: optineurin. (490 aa)
PPM1AProtein phosphatase 1A isoform X2. (382 aa)
AJUBALIM domain-containing protein ajuba. (121 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1. (346 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (664 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TNFRSF19Tumor necrosis factor receptor superfamily member 19-like isoform X3. (342 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (873 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1191 aa)
RIPK2LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2. (512 aa)
LOC103667265LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (237 aa)
RHOCRho-related GTP-binding protein RhoC. (193 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
CLEC7AC-type lectin domain family 7 member A isoform X2. (202 aa)
MTDHProtein LYRIC. (528 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
EDA2RTumor necrosis factor receptor superfamily member 27 isoform X3. (309 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3 isoform X1. (647 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (983 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
TRIM13E3 ubiquitin-protein ligase TRIM13. (407 aa)
ABL1Tyrosine-protein kinase. (1135 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (533 aa)
TRIM39-RPP21E3 ubiquitin-protein ligase TRIM39 isoform X2. (469 aa)
UBDLOW QUALITY PROTEIN: ubiquitin D-like. (154 aa)
RELProto-oncogene c-Rel isoform X1. (604 aa)
NFKBIBLOW QUALITY PROTEIN: NF-kappa-B inhibitor beta. (360 aa)
IKBKGNF-kappa-B essential modulator. (291 aa)
TRIM27LOW QUALITY PROTEIN: zinc finger protein RFP. (312 aa)
ENSUMAP00000026718annotation not available (181 aa)
ASH1LLOW QUALITY PROTEIN: histone-lysine N-methyltransferase ASH1L. (2205 aa)
TRIM61Tripartite motif-containing protein 60-like. (216 aa)
LOC103658131Putative tripartite motif-containing protein 75. (105 aa)
LOC103658124Tripartite motif-containing protein 60-like. (200 aa)
LOC103658125Putative tripartite motif-containing protein 75. (309 aa)
LURAP1LLeucine rich adaptor protein 1-like. (225 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (269 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (535 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (314 aa)
STAT1Signal transducer and activator of transcription. (809 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
S100A13Protein S100-A13 isoform X2; Belongs to the S-100 family. (137 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
SHARPINSharpin. (414 aa)
TRIM38Tripartite motif-containing protein 38. (463 aa)
EDARTumor necrosis factor receptor superfamily member EDAR isoform X2. (447 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (582 aa)
LOC103656900LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (280 aa)
PPM1MProtein phosphatase 1M. (456 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X2; Belongs to the peptidase C14A family. (482 aa)
CASP10Caspase-10 isoform X1; Belongs to the peptidase C14A family. (481 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
UFL1E3 UFM1-protein ligase 1. (792 aa)
LIME1Lck-interacting transmembrane adapter 1. (277 aa)
ENSUMAP00000031254Glyceraldehyde-3-phosphate dehydrogenase-like. (197 aa)
RNF31E3 ubiquitin-protein ligase RNF31 isoform X1. (1080 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
RHOARas homolog family member A. (193 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (572 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2. (191 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (494 aa)
OTUD7AOTU domain-containing protein 7A. (627 aa)
DDX1ATP-dependent RNA helicase DDX1. (734 aa)
TRIM8Probable E3 ubiquitin-protein ligase TRIM8. (515 aa)
PPM1NProbable protein phosphatase 1N. (109 aa)
LURAP1LOW QUALITY PROTEIN: leucine rich adaptor protein 1. (221 aa)
TLE1Transducin-like enhancer protein 1. (714 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (714 aa)
RORALOW QUALITY PROTEIN: nuclear receptor ROR-alpha. (522 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
SQSTM1Sequestosome-1. (391 aa)
ENSUMAP00000033644annotation not available (237 aa)
LOC103669669-2Ubiquitin-conjugating enzyme E2 variant 1 isoform X2. (147 aa)
TRIM22E3 ubiquitin-protein ligase TRIM22. (494 aa)
LOC103680048Tripartite motif-containing protein 5-like isoform X2. (306 aa)
LOC103680046Tripartite motif-containing protein 34-like isoform X1. (487 aa)
S100BProtein S100; Belongs to the S-100 family. (104 aa)
TMEM106ATransmembrane protein 106A. (286 aa)
TRAF3IP2TRAF3 interacting protein 2. (563 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
LOC103677095LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (243 aa)
C18orf32Chromosome 18 open reading frame 32. (75 aa)
TIRAPLOW QUALITY PROTEIN: toll/interleukin-1 receptor domain-containing adapter protein. (225 aa)
BCL10BCL10 immune signaling adaptor. (234 aa)
ALPK1Alpha-protein kinase 1. (920 aa)
ESR1LOW QUALITY PROTEIN: estrogen receptor. (328 aa)
ENSUMAP00000002447annotation not available (165 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (263 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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