STRINGSTRING
ADAM9 ADAM9 TMEM130 TMEM130 EGFR EGFR PDGFD PDGFD PTPRJ PTPRJ ERN2 ERN2 PAQR3 PAQR3 CD300A CD300A MAP2K6 MAP2K6 NTF3 NTF3 MAP4K2 MAP4K2 SH2B3 SH2B3 HMGCR HMGCR P2RX7 P2RX7 EPGN EPGN NTRK3 NTRK3 ENSUMAP00000007957 ENSUMAP00000007957 DVL3 DVL3 NOD2 NOD2 LRRK2 LRRK2 RGS14 RGS14 PTPN1 PTPN1 FGF18 FGF18 PTPRC PTPRC CBS CBS SFRP1 SFRP1 AGER AGER FGD2 FGD2 MAP3K10 MAP3K10 FZD10 FZD10 MAP3K11 MAP3K11 TSG101 TSG101 IRAK3 IRAK3 AXIN1 AXIN1 TGFA TGFA LIME1 LIME1 MST1R MST1R TRIB1 TRIB1 DUSP10 DUSP10 SORL1 SORL1 CBLC CBLC TRAF2 TRAF2 ADRA2A ADRA2A MAP3K5 MAP3K5 FZD4 FZD4 SMPD1 SMPD1 PDCD10 PDCD10 KITLG KITLG DUSP16 DUSP16 TRIB2 TRIB2 CAV1 CAV1 TPD52L1 TPD52L1 TRIB3 TRIB3 VEGFA VEGFA LOC103677394 LOC103677394 KIT KIT LAX1 LAX1 PDGFA PDGFA BMP2 BMP2 AGT AGT MAP3K13 MAP3K13 SPRY1 SPRY1 FGF2 FGF2 DEFB114 DEFB114 TLR4 TLR4 ADIPOQ ADIPOQ PTPN6 PTPN6 DAB2IP DAB2IP TNFRSF11A TNFRSF11A SASH1 SASH1 NOX4 NOX4 LYN LYN INPP5K INPP5K NEK10 NEK10 GBA GBA CAV3 CAV3 PIK3CG PIK3CG EPHA4 EPHA4 EDN1 EDN1 PIK3R5 PIK3R5 IL34 IL34 PIK3R6 PIK3R6 DTNBP1 DTNBP1 ERN1 ERN1 TRAF6 TRAF6 SPRY3 SPRY3 CDK12 CDK12 DUSP19 DUSP19 HTR2B HTR2B FLT1 FLT1 ENSUMAP00000023341 ENSUMAP00000023341 PDGFC PDGFC SYK SYK HGS HGS SFRP2 SFRP2 TNFSF11 TNFSF11 ENSUMAP00000021840 ENSUMAP00000021840 CDK5RAP3 CDK5RAP3 BMP4 BMP4 DVL2 DVL2 TNF TNF NF1 NF1 RASGRP1 RASGRP1 SPRY2 SPRY2 PDGFB PDGFB THBS1 THBS1 INSR INSR AJUBA AJUBA KSR1 KSR1 ENSUMAP00000018377 ENSUMAP00000018377 SOS1 SOS1 TAOK3 TAOK3 MAP3K7 MAP3K7 MAP3K4 MAP3K4 SPRY4 SPRY4 FGF1 FGF1 ARHGEF5 ARHGEF5 EZH2 EZH2 PAK1 PAK1 RPS3 RPS3 NUP62CL NUP62CL TNXB TNXB MAP3K12 MAP3K12 ADAM8 ADAM8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (819 aa)
TMEM130Transmembrane protein 130. (317 aa)
EGFRReceptor protein-tyrosine kinase. (1191 aa)
PDGFDPlatelet-derived growth factor D. (365 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta isoform X1. (1203 aa)
ERN2LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE2. (891 aa)
PAQR3Progestin and adipoQ receptor family member 3. (306 aa)
CD300ACMRF35-like molecule 8. (168 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2. (894 aa)
SH2B3SH2B adapter protein 3. (368 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (601 aa)
EPGNEpithelial mitogen. (138 aa)
NTRK3Tyrosine-protein kinase receptor. (861 aa)
ENSUMAP00000007957annotation not available (154 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (423 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (817 aa)
LRRK2LOW QUALITY PROTEIN: leucine-rich repeat serine/threonine-protein kinase 2. (2513 aa)
RGS14Regulator of G-protein signaling 14 isoform X4. (563 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (424 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1268 aa)
CBSCystathionine beta-synthase. (557 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
AGERAdvanced glycosylation end product-specific receptor. (311 aa)
FGD2FYVE, RhoGEF and PH domain-containing protein 2. (764 aa)
MAP3K10LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10. (270 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (398 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase 11. (281 aa)
TSG101Tumor susceptibility gene 101 protein. (417 aa)
IRAK3Interleukin-1 receptor-associated kinase 3. (517 aa)
AXIN1Axin-1 isoform X2. (867 aa)
TGFAProtransforming growth factor alpha. (92 aa)
LIME1Lck-interacting transmembrane adapter 1. (277 aa)
MST1RMacrophage-stimulating protein receptor. (1350 aa)
TRIB1Tribbles homolog 1. (191 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
SORL1Sortilin-related receptor. (2185 aa)
CBLCE3 ubiquitin-protein ligase CBL-C. (437 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (494 aa)
ADRA2AAdrenoceptor alpha 2A. (418 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1768 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (534 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
PDCD10Programmed cell death protein 10. (212 aa)
KITLGKit ligand. (274 aa)
DUSP16LOW QUALITY PROTEIN: dual specificity protein phosphatase 16. (758 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
TPD52L1Tumor protein D53 isoform X2. (191 aa)
TRIB3Tribbles homolog 3. (145 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (179 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
KITMast/stem cell growth factor receptor Kit; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
LAX1Lymphocyte transmembrane adaptor 1. (399 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (288 aa)
BMP2Bone morphogenetic protein 2 isoform X2. (395 aa)
AGTAngiotensinogen; Belongs to the serpin family. (475 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (944 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (311 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
DEFB114Defensin beta 114. (67 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
ADIPOQAdiponectin isoform X2. (297 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
DAB2IPDisabled homolog 2-interacting protein. (877 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (274 aa)
SASH1SAM and SH3 domain-containing protein 1 isoform X1. (1239 aa)
NOX4NADPH oxidase 4. (578 aa)
LYNTyrosine-protein kinase. (512 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (455 aa)
NEK10Serine/threonine-protein kinase Nek10. (1097 aa)
GBAGlucosylceramidase. (562 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1090 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (911 aa)
EDN1Endothelin-1. (202 aa)
PIK3R5LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 5. (211 aa)
IL34Interleukin-34 isoform X1. (236 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (743 aa)
DTNBP1Dysbindin isoform X1. (305 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (1029 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
SPRY3Sprouty RTK signaling antagonist 3. (288 aa)
CDK12Cyclin-dependent kinase 12 isoform X1. (1422 aa)
DUSP19Dual specificity protein phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (221 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (645 aa)
ENSUMAP00000023341annotation not available (433 aa)
PDGFCPlatelet-derived growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
SYKTyrosine-protein kinase SYK; Belongs to the protein kinase superfamily. Tyr protein kinase family. (610 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (707 aa)
SFRP2Secreted frizzled-related protein 2. (299 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
ENSUMAP00000021840annotation not available (165 aa)
CDK5RAP3LOW QUALITY PROTEIN: CDK5 regulatory subunit-associated protein 3. (149 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (391 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NF1Neurofibromin. (2862 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (807 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
PDGFBPlatelet-derived growth factor subunit B. (234 aa)
THBS1LOW QUALITY PROTEIN: thrombospondin-1. (1168 aa)
INSRTyrosine-protein kinase receptor. (1375 aa)
AJUBALIM domain-containing protein ajuba. (121 aa)
KSR1Kinase suppressor of Ras 1. (875 aa)
ENSUMAP00000018377annotation not available (92 aa)
SOS1Son of sevenless homolog 1. (1276 aa)
TAOK3Serine/threonine-protein kinase TAO3. (923 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1511 aa)
SPRY4Protein sprouty homolog 4. (300 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (435 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (747 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
NUP62CLNucleoporin-62 C-terminal-like protein isoform X1. (184 aa)
TNXBLOW QUALITY PROTEIN: tenascin-X. (3512 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (867 aa)
ADAM8LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 8. (692 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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