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UGCG UGCG BBS4 BBS4 MKKS MKKS EBI3 EBI3 SIRT1 SIRT1 LEP LEP BBS2 BBS2 MT3 MT3 ENSUMAP00000010549 ENSUMAP00000010549 LEPR LEPR ENSUMAP00000018664 ENSUMAP00000018664 LRP2 LRP2 PID1 PID1 NR1D1 NR1D1 STAT3 STAT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UGCGCeramide glucosyltransferase. (392 aa)
BBS4Bardet-Biedl syndrome 4 protein isoform X2. (325 aa)
MKKSmcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (570 aa)
EBI3Interleukin-27 subunit beta isoform X1. (480 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X2. (446 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
MT3Metallothionein 3. (68 aa)
ENSUMAP00000010549annotation not available (144 aa)
LEPRLeptin receptor isoform X1. (1166 aa)
ENSUMAP00000018664annotation not available (401 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (403 aa)
PID1PTB-containing, cubilin and LRP1-interacting protein isoform X2. (220 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
STAT3Signal transducer and activator of transcription. (838 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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