node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBS2 | BBS4 | ENSUMAP00000001348 | ENSUMAP00000010546 | Bardet-Biedl syndrome 2 protein homolog. | Bardet-Biedl syndrome 4 protein isoform X2. | 0.999 |
BBS2 | ENSUMAP00000010549 | ENSUMAP00000001348 | ENSUMAP00000010549 | Bardet-Biedl syndrome 2 protein homolog. | annotation not available | 0.905 |
BBS2 | LEP | ENSUMAP00000001348 | ENSUMAP00000007773 | Bardet-Biedl syndrome 2 protein homolog. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.414 |
BBS4 | BBS2 | ENSUMAP00000010546 | ENSUMAP00000001348 | Bardet-Biedl syndrome 4 protein isoform X2. | Bardet-Biedl syndrome 2 protein homolog. | 0.999 |
BBS4 | ENSUMAP00000010549 | ENSUMAP00000010546 | ENSUMAP00000010549 | Bardet-Biedl syndrome 4 protein isoform X2. | annotation not available | 0.935 |
BBS4 | LEP | ENSUMAP00000010546 | ENSUMAP00000007773 | Bardet-Biedl syndrome 4 protein isoform X2. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.416 |
ENSUMAP00000010549 | BBS2 | ENSUMAP00000010549 | ENSUMAP00000001348 | annotation not available | Bardet-Biedl syndrome 2 protein homolog. | 0.905 |
ENSUMAP00000010549 | BBS4 | ENSUMAP00000010549 | ENSUMAP00000010546 | annotation not available | Bardet-Biedl syndrome 4 protein isoform X2. | 0.935 |
LEP | BBS2 | ENSUMAP00000007773 | ENSUMAP00000001348 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Bardet-Biedl syndrome 2 protein homolog. | 0.414 |
LEP | BBS4 | ENSUMAP00000007773 | ENSUMAP00000010546 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Bardet-Biedl syndrome 4 protein isoform X2. | 0.416 |
LEP | LEPR | ENSUMAP00000007773 | ENSUMAP00000011035 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Leptin receptor isoform X1. | 0.998 |
LEP | SIRT1 | ENSUMAP00000007773 | ENSUMAP00000009446 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | NAD-dependent protein deacetylase sirtuin-1 isoform X2. | 0.508 |
LEP | STAT3 | ENSUMAP00000007773 | ENSUMAP00000034771 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Signal transducer and activator of transcription. | 0.975 |
LEPR | LEP | ENSUMAP00000011035 | ENSUMAP00000007773 | Leptin receptor isoform X1. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.998 |
LEPR | STAT3 | ENSUMAP00000011035 | ENSUMAP00000034771 | Leptin receptor isoform X1. | Signal transducer and activator of transcription. | 0.658 |
SIRT1 | LEP | ENSUMAP00000009446 | ENSUMAP00000007773 | NAD-dependent protein deacetylase sirtuin-1 isoform X2. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.508 |
SIRT1 | STAT3 | ENSUMAP00000009446 | ENSUMAP00000034771 | NAD-dependent protein deacetylase sirtuin-1 isoform X2. | Signal transducer and activator of transcription. | 0.574 |
STAT3 | LEP | ENSUMAP00000034771 | ENSUMAP00000007773 | Signal transducer and activator of transcription. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.975 |
STAT3 | LEPR | ENSUMAP00000034771 | ENSUMAP00000011035 | Signal transducer and activator of transcription. | Leptin receptor isoform X1. | 0.658 |
STAT3 | SIRT1 | ENSUMAP00000034771 | ENSUMAP00000009446 | Signal transducer and activator of transcription. | NAD-dependent protein deacetylase sirtuin-1 isoform X2. | 0.574 |