STRINGSTRING
IFI35 IFI35 CDC37 CDC37 PARP9 PARP9 TRIM21 TRIM21 CD160 CD160 POLR3C POLR3C ADAM8 ADAM8 AKIRIN2 AKIRIN2 YTHDF2 YTHDF2 TRIM56 TRIM56 FGR FGR LOC103668179 LOC103668179 TRAFD1 TRAFD1 TRIM62 TRIM62 SFPQ SFPQ PTPN2 PTPN2 CACTIN CACTIN FADD FADD EREG EREG COCH COCH N4BP1 N4BP1 INS-IGF2 INS-IGF2 LEP LEP NOD2 NOD2 RBM14 RBM14 TKFC TKFC TYRO3 TYRO3 TREM2 TREM2 TREML1 TREML1 MB21D1 MB21D1 VAV1 VAV1 CXorf21 CXorf21 GRN GRN PSPC1 PSPC1 YTHDF3 YTHDF3 PYCARD PYCARD HEXIM1 HEXIM1 RASGRP1 RASGRP1 ENSUMAP00000020575 ENSUMAP00000020575 NCR3 NCR3 PLCG2 PLCG2 RNF135 RNF135 NFE2L2 NFE2L2 STING1 STING1 MATR3 MATR3 RNF185 RNF185 LOC103669171 LOC103669171 LOC103669174 LOC103669174 LOC103669127 LOC103669127 LOC103669128 LOC103669128 ENSUMAP00000022175 ENSUMAP00000022175 LOC103669129 LOC103669129 ENSUMAP00000022194 ENSUMAP00000022194 KLRK1 KLRK1 KLRD1 KLRD1 CLEC12B CLEC12B KLRF1 KLRF1 KLRB1 KLRB1 SYK SYK SUSD4 SUSD4 KLRG1 KLRG1 STAT2 STAT2 VSIG4 VSIG4 HMGB1 HMGB1 MED1 MED1 POLR3B POLR3B APPL2 APPL2 PIK3R6 PIK3R6 AP1G1 AP1G1 GIMAP5 GIMAP5 SERPING1 SERPING1 MUL1 MUL1 PLA2G5 PLA2G5 LSM14A LSM14A APPL1 APPL1 DCST1 DCST1 ADAR ADAR ATG5 ATG5 XRCC5 XRCC5 RIOK3 RIOK3 USP15 USP15 TTLL12 TTLL12 TBK1 TBK1 IRAK3 IRAK3 CNOT7 CNOT7 TYROBP TYROBP LAMP1 LAMP1 XRCC6 XRCC6 AKIRIN1 AKIRIN1 LRP8 LRP8 CRTAM CRTAM DUSP10 DUSP10 SH2D1B SH2D1B DHX58 DHX58 PVR PVR NECTIN2 NECTIN2 STAT5B STAT5B ENSUMAP00000032829 ENSUMAP00000032829 LOC103679927 LOC103679927 ATG12 ATG12 TNFAIP3 TNFAIP3 ZNFX1 ZNFX1 SH2D1A SH2D1A LOC103680048 LOC103680048 POLR3F POLR3F POLR3D POLR3D LAG3 LAG3 METTL3 METTL3 CD96 CD96 IL21 IL21 CD226 CD226 ENSUMAP00000005498 ENSUMAP00000005498 TLR4 TLR4 MAVS MAVS IKBKE IKBKE SAMHD1 SAMHD1 SIN3A SIN3A CADM1 CADM1 CLEC6A CLEC6A HAVCR2 HAVCR2 ISG15 ISG15 ZBP1 ZBP1 IRF3 IRF3 TIRAP TIRAP TXK TXK TOMM70 TOMM70 MNDA MNDA LOC103672063 LOC103672063 UBE2K UBE2K HPX HPX CASP6 CASP6 NLRC5 NLRC5 TREX1 TREX1 LYAR LYAR SLAMF6 SLAMF6 NMI NMI NLRX1 NLRX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFI35LOW QUALITY PROTEIN: interferon-induced 35 kDa protein. (260 aa)
CDC37Hsp90 co-chaperone Cdc37. (227 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (827 aa)
TRIM21E3 ubiquitin-protein ligase TRIM21. (469 aa)
CD160LOW QUALITY PROTEIN: CD160 antigen. (147 aa)
POLR3CRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa)
ADAM8LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 8. (692 aa)
AKIRIN2Akirin-2. (190 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (530 aa)
TRIM56E3 ubiquitin-protein ligase TRIM56. (716 aa)
FGRTyrosine-protein kinase. (577 aa)
LOC103668179LOW QUALITY PROTEIN: high mobility group protein B1-like. (200 aa)
TRAFD1TRAF-type zinc finger domain-containing protein 1. (583 aa)
TRIM62LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIM62. (285 aa)
SFPQSplicing factor, proline- and glutamine-rich. (341 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (400 aa)
CACTINCactin. (189 aa)
FADDFAS-associated death domain protein. (192 aa)
EREGProepiregulin. (175 aa)
COCHCochlin. (610 aa)
N4BP1NEDD4-binding protein 1 isoform X1. (810 aa)
INS-IGF2Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (199 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (817 aa)
RBM14RNA-binding protein 14. (542 aa)
TKFCBifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (Cyclizing). (724 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3. (845 aa)
TREM2Triggering receptor expressed on myeloid cells 2 isoform X2. (322 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (313 aa)
MB21D1Cyclic GMP-AMP synthase. (209 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
CXorf21Chromosome X open reading frame 21. (297 aa)
GRNGranulins isoform X1. (724 aa)
PSPC1LOW QUALITY PROTEIN: paraspeckle component 1. (487 aa)
YTHDF3YTH domain-containing family protein 3 isoform X1. (588 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
HEXIM1Protein HEXIM1. (247 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (807 aa)
ENSUMAP00000020575annotation not available (177 aa)
NCR3LOW QUALITY PROTEIN: natural cytotoxicity triggering receptor 3. (182 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1191 aa)
RNF135E3 ubiquitin-protein ligase RNF135. (260 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X2. (590 aa)
STING1Stimulator of interferon genes protein. (378 aa)
MATR3Matrin-3 isoform X1. (863 aa)
RNF185E3 ubiquitin-protein ligase RNF185. (192 aa)
LOC103669171Killer cell lectin-like receptor 3. (267 aa)
LOC103669174NKG2-A/NKG2-B type II integral membrane protein-like. (229 aa)
LOC103669127NKG2-F type II integral membrane protein-like isoform X1. (229 aa)
LOC103669128NKG2-A/NKG2-B type II integral membrane protein-like isoform X1. (180 aa)
ENSUMAP00000022175NKG2-F type II integral membrane protein-like. (165 aa)
LOC103669129NKG2-A/NKG2-B type II integral membrane protein-like. (228 aa)
ENSUMAP00000022194annotation not available (236 aa)
KLRK1NKG2-D type II integral membrane protein isoform X1. (180 aa)
KLRD1Natural killer cells antigen CD94 isoform X1. (179 aa)
CLEC12BC-type lectin domain family 12 member B. (225 aa)
KLRF1Killer cell lectin-like receptor subfamily F member 1 isoform X1. (242 aa)
KLRB1Killer cell lectin-like receptor subfamily B member 1 isoform X1. (213 aa)
SYKTyrosine-protein kinase SYK; Belongs to the protein kinase superfamily. Tyr protein kinase family. (610 aa)
SUSD4Sushi domain-containing protein 4. (478 aa)
KLRG1Killer cell lectin-like receptor subfamily G member 1. (213 aa)
STAT2Signal transducer and activator of transcription. (848 aa)
VSIG4V-set and immunoglobulin domain-containing protein 4 isoform X2. (385 aa)
HMGB1High mobility group protein B1. (215 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
POLR3BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (619 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (743 aa)
AP1G1AP-1 complex subunit gamma. (822 aa)
GIMAP5GTPase IMAP family member 5 isoform X1. (488 aa)
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (481 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (252 aa)
PLA2G5Phospholipase A(2). (137 aa)
LSM14AProtein LSM14 homolog A isoform X1. (440 aa)
APPL1DCC-interacting protein 13-alpha. (656 aa)
DCST1DC-STAMP domain-containing protein 1. (666 aa)
ADARDouble-stranded RNA-specific adenosine deaminase. (1150 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (535 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (927 aa)
TTLL12Tubulin--tyrosine ligase-like protein 12. (591 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
IRAK3Interleukin-1 receptor-associated kinase 3. (517 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
TYROBPTYRO protein tyrosine kinase-binding protein isoform X1. (102 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (406 aa)
XRCC6X-ray repair cross-complementing protein 6 isoform X1. (607 aa)
AKIRIN1Akirin-1. (188 aa)
LRP8LDL receptor related protein 8. (925 aa)
CRTAMCytotoxic and regulatory T-cell molecule isoform X1. (391 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
SH2D1BSH2 domain-containing protein 1B. (143 aa)
DHX58Probable ATP-dependent RNA helicase DHX58. (722 aa)
PVRPoliovirus receptor. (427 aa)
NECTIN2Nectin-2. (543 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
ENSUMAP00000032829annotation not available (407 aa)
LOC103679927Ficolin-1-like isoform X3. (326 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (714 aa)
ZNFX1NFX1-type zinc finger-containing protein 1. (1919 aa)
SH2D1ASH2 domain-containing protein 1A. (83 aa)
LOC103680048Tripartite motif-containing protein 5-like isoform X2. (306 aa)
POLR3FDNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (323 aa)
POLR3DDNA-directed RNA polymerase III subunit RPC4 isoform X1. (398 aa)
LAG3Lymphocyte activation gene 3 protein. (502 aa)
METTL3N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa)
CD96T-cell surface protein tactile. (512 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
CD226CD226 molecule. (336 aa)
ENSUMAP00000005498annotation not available (97 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
MAVSLOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein. (710 aa)
IKBKELOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon. (692 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
CADM1Cell adhesion molecule 1. (441 aa)
CLEC6ALOW QUALITY PROTEIN: C-type lectin domain family 6 member A. (231 aa)
HAVCR2Hepatitis A virus cellular receptor 2 isoform X1. (280 aa)
ISG15ISG15 ubiquitin like modifier. (157 aa)
ZBP1Z-DNA-binding protein 1 isoform X1. (444 aa)
IRF3Interferon regulatory factor 3 isoform X2. (421 aa)
TIRAPLOW QUALITY PROTEIN: toll/interleukin-1 receptor domain-containing adapter protein. (225 aa)
TXKTyrosine-protein kinase. (527 aa)
TOMM70Mitochondrial import receptor subunit TOM70. (565 aa)
MNDAMyeloid cell nuclear differentiation antigen-like. (434 aa)
LOC103672063Myeloid cell nuclear differentiation antigen-like protein isoform X1. (726 aa)
UBE2KUbiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
HPXHemopexin. (396 aa)
CASP6Caspase-6; Belongs to the peptidase C14A family. (140 aa)
NLRC5Protein NLRC5. (1728 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
LYARCell growth-regulating nucleolar protein. (387 aa)
SLAMF6SLAM family member 6 isoform X1. (265 aa)
NMIN-myc-interactor isoform X1. (336 aa)
NLRX1NLR family member X1. (1463 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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