(18 nodes) Positive regulation of epidermal cell differentiation network (Ursus maritimus)

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Your Input:
	VDR	Vitamin D3 receptor isoform X2. (427 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	ZBED2	Zinc finger BED domain-containing protein 2. (217 aa)
	TRIM16	Tripartite motif-containing protein 16. (558 aa)
	NUMA1	Nuclear mitotic apparatus protein 1 isoform X1. (2143 aa)
	CYP27C1	Cytochrome P450 27C1; Belongs to the cytochrome P450 family. (372 aa)
	PTCH1	Protein patched homolog 1. (1388 aa)
	SFRP4	Secreted frizzled-related protein 4. (254 aa)
	KDF1	Keratinocyte differentiation factor 1. (397 aa)
	SFN	14-3-3 protein sigma; Belongs to the 14-3-3 family. (258 aa)
	PRKCH	Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	ALOX15B	Arachidonate 15-lipoxygenase B. (524 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
	MACROH2A1	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
	CYP27B1	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
	PTCH2	LOW QUALITY PROTEIN: protein patched homolog 2. (1189 aa)
	NCOA3	Nuclear receptor coactivator. (1435 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGF2	ENSUMAP00000021648	ENSUMAP00000005828	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.769
BMP4	PTCH1	ENSUMAP00000021648	ENSUMAP00000013120	Bone morphogenetic protein 4.	Protein patched homolog 1.	0.525
CYP27B1	MED1	ENSUMAP00000027715	ENSUMAP00000023808	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.514
CYP27B1	VDR	ENSUMAP00000027715	ENSUMAP00000001083	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family.	Vitamin D3 receptor isoform X2.	0.840
CYP27C1	MED1	ENSUMAP00000011137	ENSUMAP00000023808	Cytochrome P450 27C1; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.514
FGF2	BMP4	ENSUMAP00000005828	ENSUMAP00000021648	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.769
KDF1	SFN	ENSUMAP00000016164	ENSUMAP00000016188	Keratinocyte differentiation factor 1.	14-3-3 protein sigma; Belongs to the 14-3-3 family.	0.454
MED1	CYP27B1	ENSUMAP00000023808	ENSUMAP00000027715	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family.	0.514
MED1	CYP27C1	ENSUMAP00000023808	ENSUMAP00000011137	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Cytochrome P450 27C1; Belongs to the cytochrome P450 family.	0.514
MED1	NCOA3	ENSUMAP00000023808	ENSUMAP00000034123	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor coactivator.	0.962
MED1	VDR	ENSUMAP00000023808	ENSUMAP00000001083	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Vitamin D3 receptor isoform X2.	0.877
NCOA3	MED1	ENSUMAP00000034123	ENSUMAP00000023808	Nuclear receptor coactivator.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.962
NCOA3	VDR	ENSUMAP00000034123	ENSUMAP00000001083	Nuclear receptor coactivator.	Vitamin D3 receptor isoform X2.	0.792
PTCH1	BMP4	ENSUMAP00000013120	ENSUMAP00000021648	Protein patched homolog 1.	Bone morphogenetic protein 4.	0.525
PTCH1	PTCH2	ENSUMAP00000013120	ENSUMAP00000033712	Protein patched homolog 1.	LOW QUALITY PROTEIN: protein patched homolog 2.	0.915
PTCH1	SFRP4	ENSUMAP00000013120	ENSUMAP00000015100	Protein patched homolog 1.	Secreted frizzled-related protein 4.	0.473
PTCH2	PTCH1	ENSUMAP00000033712	ENSUMAP00000013120	LOW QUALITY PROTEIN: protein patched homolog 2.	Protein patched homolog 1.	0.915
PTCH2	SFRP4	ENSUMAP00000033712	ENSUMAP00000015100	LOW QUALITY PROTEIN: protein patched homolog 2.	Secreted frizzled-related protein 4.	0.473
SFN	KDF1	ENSUMAP00000016188	ENSUMAP00000016164	14-3-3 protein sigma; Belongs to the 14-3-3 family.	Keratinocyte differentiation factor 1.	0.454
SFRP4	PTCH1	ENSUMAP00000015100	ENSUMAP00000013120	Secreted frizzled-related protein 4.	Protein patched homolog 1.	0.473