STRINGSTRING
ABCB10 ABCB10 CD101 CD101 IL17A IL17A CD74 CD74 RHEX RHEX RAB7B RAB7B FAXDC2 FAXDC2 ETS1 ETS1 FAM210B FAM210B ISG15 ISG15 PRMT1 PRMT1 KITLG KITLG LEF1 LEF1 SLC9B2 SLC9B2 LOC103677394 LOC103677394 GPR68 GPR68 RCOR1 RCOR1 FADD FADD GATA1 GATA1 FOS FOS JAG1 JAG1 ACVR1B ACVR1B FES FES PRKDC PRKDC INHBA INHBA ZFP36L1 ZFP36L1 TESC TESC NCKAP1L NCKAP1L SMAP1 SMAP1 TREM2 TREM2 TREML1 TREML1 PITHD1 PITHD1 CSF1 CSF1 HIF1A HIF1A INPP5D INPP5D TNF TNF EVI2B EVI2B ANKRD54 ANKRD54 KAT7 KAT7 TMEM64 TMEM64 TNFSF11 TNFSF11 PLA2G3 PLA2G3 LIF LIF PPARGC1B PPARGC1B IL23A IL23A MED1 MED1 TRAF6 TRAF6 CSF3 CSF3 IL34 IL34 NEDD9 NEDD9 RB1 RB1 RIPK1 RIPK1 BRD1 BRD1 KLF10 KLF10 FOXO3 FOXO3 DCSTAMP DCSTAMP HAX1 HAX1 STAT1 STAT1 IFNG IFNG PRKCA PRKCA CASP10 CASP10 CASP8 CASP8 SCIN SCIN TRIB1 TRIB1 CREB1 CREB1 STAT5B STAT5B CTNNBIP1 CTNNBIP1 STAT3 STAT3 OCSTAMP OCSTAMP HCLS1 HCLS1 IL20 IL20 NOTCH2 NOTCH2 THPO THPO PPP3CA PPP3CA CD4 CD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABCB10ATP-binding cassette sub-family B member 10, mitochondrial. (545 aa)
CD101Immunoglobulin superfamily member 2 isoform X1. (1019 aa)
IL17Ainterleukin-17A. (161 aa)
CD74LOW QUALITY PROTEIN: HLA class II histocompatibility antigen gamma chain. (279 aa)
RHEXRegulator of hemoglobinization and erythroid cell expansion. (172 aa)
RAB7BRAB7B, member RAS oncogene family. (200 aa)
FAXDC2Fatty acid hydroxylase domain-containing protein 2 isoform X1; Belongs to the sterol desaturase family. (420 aa)
ETS1ETS proto-oncogene 1, transcription factor; Transcription factor; Belongs to the ETS family. (468 aa)
FAM210BProtein FAM210B. (160 aa)
ISG15ISG15 ubiquitin like modifier. (157 aa)
PRMT1Protein arginine N-methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (286 aa)
KITLGKit ligand. (274 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X2. (450 aa)
SLC9B2Mitochondrial sodium/hydrogen exchanger 9B2. (537 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (211 aa)
RCOR1REST corepressor 1. (397 aa)
FADDFAS-associated death domain protein. (192 aa)
GATA1LOW QUALITY PROTEIN: erythroid transcription factor. (438 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (481 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (777 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4135 aa)
INHBAInhibin subunit beta A. (424 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1. (338 aa)
TESCCalcineurin B homologous protein 3. (263 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
SMAP1Stromal membrane-associated protein 1 isoform X1. (372 aa)
TREM2Triggering receptor expressed on myeloid cells 2 isoform X2. (322 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (313 aa)
PITHD1PITH domain-containing protein 1. (118 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1137 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
EVI2BEcotropic viral integration site 2B. (454 aa)
ANKRD54Ankyrin repeat domain-containing protein 54. (187 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (617 aa)
TMEM64Transmembrane protein 64. (186 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
PLA2G3Group 3 secretory phospholipase A2. (513 aa)
LIFLeukemia inhibitory factor. (204 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta. (1023 aa)
IL23AInterleukin-23 subunit alpha. (190 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
IL34Interleukin-34 isoform X1. (236 aa)
NEDD9Enhancer of filamentation 1. (842 aa)
RB1Retinoblastoma-associated protein. (920 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
BRD1Bromodomain-containing protein 1. (1165 aa)
KLF10Krueppel-like factor 10. (480 aa)
FOXO3Forkhead box protein O3. (453 aa)
DCSTAMPDendritic cell-specific transmembrane protein isoform X2. (470 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (238 aa)
STAT1Signal transducer and activator of transcription. (809 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
CASP10Caspase-10 isoform X1; Belongs to the peptidase C14A family. (481 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
SCINAdseverin. (739 aa)
TRIB1Tribbles homolog 1. (191 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
STAT3Signal transducer and activator of transcription. (838 aa)
OCSTAMPLOW QUALITY PROTEIN: osteoclast stimulatory transmembrane protein. (481 aa)
HCLS1Hematopoietic lineage cell-specific protein. (510 aa)
IL20Interleukin-20. (176 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2444 aa)
THPOLOW QUALITY PROTEIN: thrombopoietin. (338 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
CD4T-cell surface glycoprotein CD4. (460 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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