STRINGSTRING
IL34 IL34 LOC103677394 LOC103677394 FADD FADD CSF1 CSF1 LIF LIF RB1 RB1 RIPK1 RIPK1 PRKCA PRKCA CASP10 CASP10 CASP8 CASP8 TRIB1 TRIB1 HCLS1 HCLS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL34Interleukin-34 isoform X1. (236 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
FADDFAS-associated death domain protein. (192 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
LIFLeukemia inhibitory factor. (204 aa)
RB1Retinoblastoma-associated protein. (920 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
CASP10Caspase-10 isoform X1; Belongs to the peptidase C14A family. (481 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
TRIB1Tribbles homolog 1. (191 aa)
HCLS1Hematopoietic lineage cell-specific protein. (510 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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