(19 nodes) Negative regulation of myoblast differentiation network (Ursus maritimus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	CXCL10	C-X-C motif chemokine. (98 aa)
	LOC103677394	Transforming growth factor beta-1. (299 aa)
	PRICKLE1	Prickle-like protein 1. (804 aa)
	SOSTDC1	Sclerostin domain-containing protein 1. (206 aa)
	CCL17	C-C motif chemokine. (109 aa)
	SOX8	Transcription factor SOX-8. (216 aa)
	TMEM182	Transmembrane protein 182 isoform X1. (229 aa)
	MSTN	Growth/differentiation factor 8. (368 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
	CXCL14	C-X-C motif chemokine ligand 14. (153 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	CMTM5	CKLF-like MARVEL transmembrane domain-containing protein 5. (233 aa)
	SRA1	Steroid receptor RNA activator 1. (266 aa)
	ID3	Inhibitor of DNA binding 3, HLH protein. (119 aa)
	MBNL3	Muscleblind-like protein 3. (346 aa)
	TBX3	LOW QUALITY PROTEIN: T-box transcription factor TBX3. (130 aa)
	PPARD	LOW QUALITY PROTEIN: peroxisome proliferator-activated receptor delta. (397 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (695 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	TBX3	ENSUMAP00000021648	ENSUMAP00000014725	Bone morphogenetic protein 4.	LOW QUALITY PROTEIN: T-box transcription factor TBX3.	0.483
CCL17	CXCL10	ENSUMAP00000029994	ENSUMAP00000010170	C-C motif chemokine.	C-X-C motif chemokine.	0.723
CCL17	CXCL14	ENSUMAP00000029994	ENSUMAP00000023812	C-C motif chemokine.	C-X-C motif chemokine ligand 14.	0.948
CCL17	TNF	ENSUMAP00000029994	ENSUMAP00000020603	C-C motif chemokine.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.550
CXCL10	CCL17	ENSUMAP00000010170	ENSUMAP00000029994	C-X-C motif chemokine.	C-C motif chemokine.	0.723
CXCL10	CXCL14	ENSUMAP00000010170	ENSUMAP00000023812	C-X-C motif chemokine.	C-X-C motif chemokine ligand 14.	0.955
CXCL10	LOC103677394	ENSUMAP00000010170	ENSUMAP00000007299	C-X-C motif chemokine.	Transforming growth factor beta-1.	0.440
CXCL10	TNF	ENSUMAP00000010170	ENSUMAP00000020603	C-X-C motif chemokine.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.792
CXCL14	CCL17	ENSUMAP00000023812	ENSUMAP00000029994	C-X-C motif chemokine ligand 14.	C-C motif chemokine.	0.948
CXCL14	CXCL10	ENSUMAP00000023812	ENSUMAP00000010170	C-X-C motif chemokine ligand 14.	C-X-C motif chemokine.	0.955
DDIT3	TNF	ENSUMAP00000027291	ENSUMAP00000020603	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.526
LOC103677394	CXCL10	ENSUMAP00000007299	ENSUMAP00000010170	Transforming growth factor beta-1.	C-X-C motif chemokine.	0.440
LOC103677394	TNF	ENSUMAP00000007299	ENSUMAP00000020603	Transforming growth factor beta-1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.811
TBX3	BMP4	ENSUMAP00000014725	ENSUMAP00000021648	LOW QUALITY PROTEIN: T-box transcription factor TBX3.	Bone morphogenetic protein 4.	0.483
TNF	CCL17	ENSUMAP00000020603	ENSUMAP00000029994	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	C-C motif chemokine.	0.550
TNF	CXCL10	ENSUMAP00000020603	ENSUMAP00000010170	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	C-X-C motif chemokine.	0.792
TNF	DDIT3	ENSUMAP00000020603	ENSUMAP00000027291	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.526
TNF	LOC103677394	ENSUMAP00000020603	ENSUMAP00000007299	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Transforming growth factor beta-1.	0.811