(97 nodes) Regulation of neuron differentiation network (Ursus maritimus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	SFRP1	Secreted frizzled-related protein 1. (305 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	CDK5RAP2	CDK5 regulatory subunit-associated protein 2 isoform X1. (1845 aa)
	BCL6	B-cell lymphoma 6 protein isoform X1. (706 aa)
	SIN3A	SIN3 transcription regulator family member A. (1274 aa)
	CNTN2	Contactin-2. (1008 aa)
	ENSUMAP00000004364	annotation not available (196 aa)
	TCF4	Transcription factor 4 isoform X5. (511 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	ENSUMAP00000002583	annotation not available (205 aa)
	CDON	Cell adhesion molecule-related/down-regulated by oncogenes isoform X1. (1271 aa)
	PCP4	Purkinje cell protein 4. (62 aa)
	NTF4	LOW QUALITY PROTEIN: neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
	PHOX2B	Paired mesoderm homeobox protein 2B. (187 aa)
	VWC2L	Von Willebrand factor C domain-containing protein 2-like. (222 aa)
	DDX6	Probable ATP-dependent RNA helicase DDX6; Belongs to the DEAD box helicase family. (483 aa)
	HES1	Transcription factor HES-1. (166 aa)
	ID1	DNA-binding protein inhibitor ID-1. (284 aa)
	BEND6	BEN domain-containing protein 6. (279 aa)
	TTC3	LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TTC3. (1999 aa)
	GDF11	Growth/differentiation factor 11. (432 aa)
	SFRP2	Secreted frizzled-related protein 2. (299 aa)
	NREP	Neuronal regeneration-related protein. (68 aa)
	LRRC45	Leucine-rich repeat-containing protein 45. (619 aa)
	MYCL	LOW QUALITY PROTEIN: protein L-Myc. (342 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
	PROX1	Prospero homeobox protein 1. (737 aa)
	ZC4H2	LOW QUALITY PROTEIN: zinc finger C4H2 domain-containing protein. (212 aa)
	IMPACT	Impact RWD domain protein. (300 aa)
	SOX8	Transcription factor SOX-8. (216 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
	BRINP3	BMP/retinoic acid-inducible neural-specific protein 3. (767 aa)
	BRINP2	BMP/retinoic acid-inducible neural-specific protein 2. (751 aa)
	BMP6	Bone morphogenetic protein 6. (364 aa)
	CNTF	Ciliary neurotrophic factor. (200 aa)
	ARHGEF2	Rho guanine nucleotide exchange factor 2. (725 aa)
	ZFHX3	Zinc finger homeobox protein 3. (3611 aa)
	DUOXA1	Dual oxidase maturation factor 1. (342 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
	ENSUMAP00000025747	annotation not available (76 aa)
	HEYL	Hairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (305 aa)
	PAX6	Paired box protein Pax-6 isoform X2. (450 aa)
	CTDSP1	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1. (336 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
	MIB1	LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase MIB1. (974 aa)
	NR2E1	LOW QUALITY PROTEIN: nuclear receptor subfamily 2 group E member 1. (372 aa)
	MMD	Monocyte to macrophage differentiation factor isoform X2. (246 aa)
	ZEB1	Zinc finger E-box-binding homeobox 1. (1086 aa)
	EIF4ENIF1	Eukaryotic translation initiation factor 4E nuclear import factor 1. (985 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
	ZFHX2	LOW QUALITY PROTEIN: zinc finger homeobox protein 2. (1409 aa)
	APP	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (747 aa)
	DLX1	LOW QUALITY PROTEIN: homeobox protein DLX-1. (243 aa)
	SPAG9	C-Jun-amino-terminal kinase-interacting protein 4. (1268 aa)
	ZNF536	LOW QUALITY PROTEIN: zinc finger protein 536. (1176 aa)
	YWHAG	14-3-3 protein gamma; Belongs to the 14-3-3 family. (238 aa)
	CYB5D2	Neuferricin. (212 aa)
	ADRA2B	LOW QUALITY PROTEIN: alpha-2B adrenergic receptor. (463 aa)
	NGF	Beta-nerve growth factor; Belongs to the NGF-beta family. (356 aa)
	TBX6	LOW QUALITY PROTEIN: T-box transcription factor TBX6. (407 aa)
	GDPD5	LOW QUALITY PROTEIN: glycerophosphodiester phosphodiesterase domain-containing protein 5. (651 aa)
	GLI3	Transcriptional activator GLI3. (524 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
	ENSUMAP00000011628	annotation not available (93 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (695 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	BIN1	Myc box-dependent-interacting protein 1 isoform X14. (523 aa)
	REST	RE1-silencing transcription factor. (1213 aa)
	ECT2	Protein ECT2. (641 aa)
	ENSUMAP00000010661	annotation not available (263 aa)
	NLGN1	Neuroligin-1 isoform X1. (608 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
	MMD2	Monocyte to macrophage differentiation factor 2 isoform X1. (257 aa)
	DIXDC1	DIX domain containing 1. (472 aa)
	RNF112	RING finger protein 112. (425 aa)
	ISL1	Insulin gene enhancer protein ISL-1. (349 aa)
	FOXG1	Forkhead box protein G1. (221 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform X3. (433 aa)
	BMP2	Bone morphogenetic protein 2 isoform X2. (395 aa)
	MAP3K13	Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (944 aa)
	EIF4E	Eukaryotic Translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	FEZF1	Fez family zinc finger protein 1. (475 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	NEPRO	Uncharacterized protein C3orf17 homolog. (488 aa)
	TRIM32	E3 ubiquitin-protein ligase TRIM32. (654 aa)
	CPNE1	Copine-1. (537 aa)
	GPR37L1	G protein-coupled receptor 37 like 1. (476 aa)
	BRINP1	BMP/retinoic acid-inducible neural-specific protein 1. (761 aa)
	ZHX2	Zinc fingers and homeoboxes protein 2. (840 aa)
	DISP3	Dispatched RND transporter family member 3. (1393 aa)
	CASZ1	LOW QUALITY PROTEIN: zinc finger protein castor homolog 1. (294 aa)
	ARHGAP35	Rho GTPase-activating protein 35. (1500 aa)
	CNTN4	Contactin-4. (1018 aa)
	HES3	Transcription factor HES-3. (179 aa)
	LRRK2	LOW QUALITY PROTEIN: leucine-rich repeat serine/threonine-protein kinase 2. (2513 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	CNTN2	ENSUMAP00000020202	ENSUMAP00000004521	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Contactin-2.	0.651
APP	CNTN4	ENSUMAP00000020202	ENSUMAP00000033410	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Contactin-4.	0.728
APP	ITGB1	ENSUMAP00000020202	ENSUMAP00000021969	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Integrin beta; Belongs to the integrin beta chain family.	0.520
APP	NGF	ENSUMAP00000020202	ENSUMAP00000015649	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Beta-nerve growth factor; Belongs to the NGF-beta family.	0.511
BCL6	SIN3A	ENSUMAP00000005041	ENSUMAP00000004652	B-cell lymphoma 6 protein isoform X1.	SIN3 transcription regulator family member A.	0.608
BMP2	BMP4	ENSUMAP00000006638	ENSUMAP00000021648	Bone morphogenetic protein 2 isoform X2.	Bone morphogenetic protein 4.	0.928
BMP2	BMP6	ENSUMAP00000006638	ENSUMAP00000025251	Bone morphogenetic protein 2 isoform X2.	Bone morphogenetic protein 6.	0.959
BMP2	FGF2	ENSUMAP00000006638	ENSUMAP00000005828	Bone morphogenetic protein 2 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.729
BMP2	FGF20	ENSUMAP00000006638	ENSUMAP00000028345	Bone morphogenetic protein 2 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.527
BMP2	ITGB1	ENSUMAP00000006638	ENSUMAP00000021969	Bone morphogenetic protein 2 isoform X2.	Integrin beta; Belongs to the integrin beta chain family.	0.544
BMP2	NGF	ENSUMAP00000006638	ENSUMAP00000015649	Bone morphogenetic protein 2 isoform X2.	Beta-nerve growth factor; Belongs to the NGF-beta family.	0.458
BMP4	BMP2	ENSUMAP00000021648	ENSUMAP00000006638	Bone morphogenetic protein 4.	Bone morphogenetic protein 2 isoform X2.	0.928
BMP4	BMP6	ENSUMAP00000021648	ENSUMAP00000025251	Bone morphogenetic protein 4.	Bone morphogenetic protein 6.	0.967
BMP4	CNTF	ENSUMAP00000021648	ENSUMAP00000025255	Bone morphogenetic protein 4.	Ciliary neurotrophic factor.	0.440
BMP4	FGF2	ENSUMAP00000021648	ENSUMAP00000005828	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.769
BMP4	FGF20	ENSUMAP00000021648	ENSUMAP00000028345	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.535
BMP4	ISL1	ENSUMAP00000021648	ENSUMAP00000007553	Bone morphogenetic protein 4.	Insulin gene enhancer protein ISL-1.	0.456
BMP4	ITGB1	ENSUMAP00000021648	ENSUMAP00000021969	Bone morphogenetic protein 4.	Integrin beta; Belongs to the integrin beta chain family.	0.410
BMP4	JAG1	ENSUMAP00000021648	ENSUMAP00000011268	Bone morphogenetic protein 4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.661
BMP4	MEF2C	ENSUMAP00000021648	ENSUMAP00000006803	Bone morphogenetic protein 4.	Myocyte-specific enhancer factor 2C isoform X3.	0.406