STRINGSTRING
SMARCA2 SMARCA2 IP6K2 IP6K2 HNF4A HNF4A SPHK2 SPHK2 NME6 NME6 WNT3A WNT3A LOC103673775 LOC103673775 LOC103673777 LOC103673777 MT3 MT3 BBS2 BBS2 ENSUMAP00000001578 ENSUMAP00000001578 GJA1 GJA1 SEMA4F SEMA4F DCBLD2 DCBLD2 LOC103670936 LOC103670936 CDKN1B CDKN1B GSK3A GSK3A RERG RERG ST7 ST7 ULK1 ULK1 SEMA6C SEMA6C SOCS2 SOCS2 SMAD4 SMAD4 SLIT2 SLIT2 ENSUMAP00000004324 ENSUMAP00000004324 OSTN OSTN BCL6 BCL6 HRG HRG CCAR2 CCAR2 LGMN LGMN FLCN FLCN WWC3 WWC3 ING4 ING4 SEMA7A SEMA7A PML PML SAV1 SAV1 LOC103677394 LOC103677394 STK11 STK11 CIRBP CIRBP NKD1 NKD1 YJEFN3 YJEFN3 NDUFA13 NDUFA13 C10orf90 C10orf90 ENSUMAP00000008777 ENSUMAP00000008777 SIRT1 SIRT1 GNG4 GNG4 MYL2 MYL2 ENSUMAP00000009628 ENSUMAP00000009628 SEMA6B SEMA6B SEMA4B SEMA4B CYP27C1 CYP27C1 DIP2B DIP2B FBP1 FBP1 RBBP7 RBBP7 PLAC8 PLAC8 ACVRL1 ACVRL1 ACVR1B ACVR1B PTPRJ PTPRJ GDF15 GDF15 NDUFS3 NDUFS3 PTPRS PTPRS RACK1 RACK1 SEMA6D SEMA6D PTCH1 PTCH1 MYOZ1 MYOZ1 INHBA INHBA PI16 PI16 FHL1 FHL1 DDX3Y DDX3Y DCUN1D3 DCUN1D3 SLC6A4 SLC6A4 TP73 TP73 TBX5 TBX5 MINAR1 MINAR1 SESN2 SESN2 SEMA4C SEMA4C GPC3 GPC3 SMAD3 SMAD3 MYL10 MYL10 PTEN PTEN ENSUMAP00000017050 ENSUMAP00000017050 SH3BP4 SH3BP4 PSRC1 PSRC1 HIF1A HIF1A SEMA3C SEMA3C ST7L ST7L PPP1R9B PPP1R9B CRLF3 CRLF3 OSGIN2 OSGIN2 RYK RYK WNT3 WNT3 GDF2 GDF2 ENSUMAP00000021277 ENSUMAP00000021277 ANKRD26 ANKRD26 PHB PHB TSPYL2 TSPYL2 BMP4 BMP4 CGRRF1 CGRRF1 SEMA4D-2 SEMA4D-2 SFRP2 SFRP2 SEMA4D SEMA4D CDK5 CDK5 SEMA3E SEMA3E RTN4 RTN4 DDX3X DDX3X TP53 TP53 SEMA3A SEMA3A STK3 STK3 FRZB FRZB ALOX15B ALOX15B SEMA3D SEMA3D ENSUMAP00000023946 ENSUMAP00000023946 JARID2 JARID2 CDKL3 CDKL3 FSTL4 FSTL4 SERPINE2 SERPINE2 GDF9 GDF9 RB1 RB1 SEMA4A SEMA4A DNAJB2 DNAJB2 MUL1 MUL1 PNPT1 PNPT1 SEMA6A SEMA6A MSTN MSTN ENSUMAP00000026525 ENSUMAP00000026525 WT1 WT1 SERTAD1 SERTAD1 SERTAD3 SERTAD3 ADAM15 ADAM15 DCSTAMP DCSTAMP CYP27B1 CYP27B1 TNR TNR FXN FXN TGFB2 TGFB2 CCN3 CCN3 BMP10 BMP10 CDKN2AIP CDKN2AIP SEMA3G SEMA3G TLL2 TLL2 WWC2 WWC2 HYAL2 HYAL2 BMPR2 BMPR2 IFRD2 IFRD2 SEMA3B SEMA3B SEMA3F SEMA3F SEMA5A SEMA5A DUSP10 DUSP10 NAIF1 NAIF1 DRAXIN DRAXIN SEMA4G SEMA4G CDKN2C CDKN2C SPART SPART CDHR2 CDHR2 ENPP1 ENPP1 SMARCA4 SMARCA4 SLIT3 SLIT3 WWC1 WWC1 CDKN2D CDKN2D EAF2 EAF2 TP53TG5 TP53TG5 STK4 STK4 SFRP1 SFRP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMARCA2LOW QUALITY PROTEIN: probable global transcription activator SNF2L2. (286 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X2. (474 aa)
SPHK2Sphingosine kinase 2. (417 aa)
NME6Nucleoside diphosphate kinase. (193 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LOC103673775Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
LOC103673777Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
MT3Metallothionein 3. (68 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
ENSUMAP00000001578annotation not available (294 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
SEMA4Fsemaphorin-4F isoform X1; Belongs to the semaphorin family. (767 aa)
DCBLD2Discoidin, CUB and LCCL domain-containing protein 2. (669 aa)
LOC103670936Neuroendocrine secretory protein 55. (247 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (185 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (417 aa)
RERGRas-related and estrogen-regulated growth inhibitor. (199 aa)
ST7Suppressor of tumorigenicity 7 protein isoform X8. (520 aa)
ULK1Serine/threonine-protein kinase ULK1. (835 aa)
SEMA6Csemaphorin-6C; Belongs to the semaphorin family. (804 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
SMAD4Mothers against decapentaplegic homolog. (546 aa)
SLIT2Slit homolog 2 protein isoform X1. (1530 aa)
ENSUMAP00000004324annotation not available (106 aa)
OSTNOsteocrin. (132 aa)
BCL6B-cell lymphoma 6 protein isoform X1. (706 aa)
HRGHistidine-rich glycoprotein. (521 aa)
CCAR2Cell cycle and apoptosis regulator protein 2 isoform X1. (918 aa)
LGMNLegumain. (433 aa)
FLCNFolliculin. (579 aa)
WWC3LOW QUALITY PROTEIN: protein WWC3. (1099 aa)
ING4Inhibitor of growth protein. (247 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (662 aa)
PMLPromyelocytic leukemia. (880 aa)
SAV1Salvador family WW domain containing protein 1. (351 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (457 aa)
CIRBPCold-inducible RNA-binding protein isoform X2. (222 aa)
NKD1Protein naked cuticle homolog 1. (446 aa)
YJEFN3yjeF N-terminal domain-containing protein 3. (142 aa)
NDUFA13NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (161 aa)
C10orf90Centrosomal protein C10orf90 homolog. (641 aa)
ENSUMAP00000008777annotation not available (79 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X2. (446 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (205 aa)
ENSUMAP00000009628annotation not available (64 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (648 aa)
SEMA4BLOW QUALITY PROTEIN: semaphorin-4B; Belongs to the semaphorin family. (847 aa)
CYP27C1Cytochrome P450 27C1; Belongs to the cytochrome P450 family. (372 aa)
DIP2BDisco-interacting protein 2 homolog B. (1459 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (320 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (391 aa)
PLAC8Placenta-specific gene 8 protein. (113 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (481 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta isoform X1. (1203 aa)
GDF15Growth/differentiation factor 15. (278 aa)
NDUFS3NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (310 aa)
PTPRSReceptor-type tyrosine-protein phosphatase S. (1655 aa)
RACK1Guanine nucleotide-binding protein subunit beta-2-like 1. (374 aa)
SEMA6Dsemaphorin-6D isoform X1; Belongs to the semaphorin family. (1086 aa)
PTCH1Protein patched homolog 1. (1388 aa)
MYOZ1Myozenin-1. (299 aa)
INHBAInhibin subunit beta A. (424 aa)
PI16LOW QUALITY PROTEIN: peptidase inhibitor 16. (305 aa)
FHL1Four and a half LIM domains protein 1. (177 aa)
DDX3YLOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (704 aa)
DCUN1D3DCN1-like protein. (304 aa)
SLC6A4Sodium-dependent serotonin transporter. (677 aa)
TP73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (595 aa)
TBX5T-box transcription factor TBX5. (474 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (917 aa)
SESN2Sestrin-2. (464 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (843 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (625 aa)
SMAD3Mothers against decapentaplegic homolog. (280 aa)
MYL10Myosin regulatory light chain 10. (217 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
ENSUMAP00000017050annotation not available (80 aa)
SH3BP4SH3 domain-binding protein 4. (962 aa)
PSRC1Proline/serine-rich coiled-coil protein 1 isoform X3. (396 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
SEMA3CSemaphorin-3C; Belongs to the semaphorin family. (750 aa)
ST7LLOW QUALITY PROTEIN: suppressor of tumorigenicity 7 protein-like. (579 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (98 aa)
CRLF3Cytokine receptor-like factor 3. (435 aa)
OSGIN2Oxidative stress induced growth inhibitor family member 2. (506 aa)
RYKTyrosine-protein kinase RYK. (572 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (175 aa)
GDF2Growth/differentiation factor 2. (402 aa)
ENSUMAP00000021277annotation not available (493 aa)
ANKRD26LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 26. (321 aa)
PHBProhibitin. (265 aa)
TSPYL2LOW QUALITY PROTEIN: testis-specific Y-encoded-like protein 2; Belongs to the nucleosome assembly protein (NAP) family. (712 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CGRRF1Cell growth regulator with RING finger domain protein 1. (332 aa)
SEMA4D-2Semaphorin 4D. (117 aa)
SFRP2Secreted frizzled-related protein 2. (299 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (777 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (361 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (781 aa)
RTN4Reticulon. (978 aa)
DDX3XDEAD-box helicase 3 X-linked. (608 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
SEMA3ASemaphorin-3A; Belongs to the semaphorin family. (772 aa)
STK3Serine/threonine-protein kinase 3. (497 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
ALOX15BArachidonate 15-lipoxygenase B. (524 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (743 aa)
ENSUMAP00000023946annotation not available (124 aa)
JARID2LOW QUALITY PROTEIN: protein Jumonji. (1137 aa)
CDKL3Cyclin-dependent kinase-like 3 isoform X2. (603 aa)
FSTL4Follistatin-related protein 4. (682 aa)
SERPINE2Glia-derived nexin; Belongs to the serpin family. (397 aa)
GDF9Growth/differentiation factor 9 isoform X4. (365 aa)
RB1Retinoblastoma-associated protein. (920 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (778 aa)
DNAJB2dnaJ homolog subfamily B member 2 isoform X1. (304 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (252 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1, mitochondrial. (793 aa)
SEMA6ALOW QUALITY PROTEIN: semaphorin-6A; Belongs to the semaphorin family. (1028 aa)
MSTNGrowth/differentiation factor 8. (368 aa)
ENSUMAP00000026525annotation not available (276 aa)
WT1Wilms tumor protein isoform X1. (305 aa)
SERTAD1SERTA domain-containing protein 1. (236 aa)
SERTAD3SERTA domain-containing protein 3. (198 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15. (772 aa)
DCSTAMPDendritic cell-specific transmembrane protein isoform X2. (470 aa)
CYP27B125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
TNRtenascin-R. (1349 aa)
FXNFrataxin, mitochondrial. (135 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
CCN3Protein NOV homolog. (220 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
CDKN2AIPCDKN2A-interacting protein. (487 aa)
SEMA3Gsemaphorin-3G; Belongs to the semaphorin family. (748 aa)
TLL2Metalloendopeptidase. (1007 aa)
WWC2Protein WWC2. (1154 aa)
HYAL2Hyaluronidase. (472 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
IFRD2Interferon-related developmental regulator 2. (561 aa)
SEMA3Bsemaphorin-3B; Belongs to the semaphorin family. (677 aa)
SEMA3Fsemaphorin-3F; Belongs to the semaphorin family. (578 aa)
SEMA5ALOW QUALITY PROTEIN: semaphorin-5A. (1055 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
NAIF1Nuclear apoptosis-inducing factor 1. (327 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (347 aa)
SEMA4GLOW QUALITY PROTEIN: semaphorin-4G; Belongs to the semaphorin family. (464 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
SPARTSpartin isoform X2. (672 aa)
CDHR2Cadherin-related family member 2. (755 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (864 aa)
SMARCA4LOW QUALITY PROTEIN: transcription activator BRG1. (1649 aa)
SLIT3Slit homolog 3 protein. (1412 aa)
WWC1Protein KIBRA. (1050 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (147 aa)
EAF2ELL-associated factor 2. (261 aa)
TP53TG5TP53-target gene 5 protein. (344 aa)
STK4Serine/threonine-protein kinase 4. (496 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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