STRINGSTRING
NSMCE2 NSMCE2 RPS6KB1 RPS6KB1 RAD51C RAD51C CUL4B CUL4B CUL4A CUL4A STAT5B STAT5B STIL STIL USP2 USP2 STAT5A STAT5A UBE2C UBE2C BIRC5 BIRC5 ENSUMAP00000019012 ENSUMAP00000019012 CENPJ CENPJ RAB11B RAB11B APP APP ADAMTS1 ADAMTS1 CCND2 CCND2 AIF1 AIF1 RPTOR RPTOR CDC27 CDC27 CDC25C CDC25C CDC23 CDC23 PLRG1 PLRG1 ANAPC11 ANAPC11 DDX3X DDX3X RRM2B RRM2B CUL3 CUL3 RB1 RB1 KMT2E KMT2E ABL1 ABL1 PPP1R10 PPP1R10 CDK4 CDK4 CDC16 CDC16 CCND1 CCND1 VPS4B VPS4B NANOG NANOG PHB2 PHB2 RRM2 RRM2 CPSF3 CPSF3 SIN3A SIN3A EIF4E EIF4E LGMN LGMN FGF10 FGF10 MAD2L1BP MAD2L1BP CDCA5 CDCA5 SASS6 SASS6 CDT1 CDT1 EGFR EGFR EIF4EBP1 EIF4EBP1 SMOC2 SMOC2 PTPN11 PTPN11 RAD51B RAD51B PRAP1 PRAP1 DDX3Y DDX3Y MBLAC1 MBLAC1 MEPCE MEPCE SHB SHB CCND3 CCND3 POLDIP2 POLDIP2 RAB11A RAB11A DUSP3 DUSP3 MTA3 MTA3 SPHK1 SPHK1 HSPA2 HSPA2 FBXO5 FBXO5 AFMID AFMID RRM1 RRM1 ANAPC5 ANAPC5 WNT10B WNT10B ANKRD17 ANKRD17 CDK1 CDK1 ANAPC7 ANAPC7 ENSUMAP00000002305 ENSUMAP00000002305 ENSUMAP00000010476 ENSUMAP00000010476 STOX1 STOX1 PRKCA PRKCA DTL DTL TFDP1 TFDP1 MDM2 MDM2 MECP2 MECP2 PKN2 PKN2 LSM10 LSM10 CDC7 CDC7 CDC25A CDC25A HES1 HES1 RCC2 RCC2 ASNS ASNS MTBP MTBP ANXA1 ANXA1 BRCA2 BRCA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (287 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAD51CDNA repair protein RAD51 homolog 3 isoform X1. (370 aa)
CUL4BLOW QUALITY PROTEIN: cullin-4B; Belongs to the cullin family. (895 aa)
CUL4Acullin-4A; Belongs to the cullin family. (856 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
STILSTIL centriolar assembly protein. (1274 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (558 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
UBE2CUbiquitin-conjugating enzyme E2 C isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (176 aa)
BIRC5Baculoviral IAP repeat containing 5. (155 aa)
ENSUMAP00000019012annotation not available (138 aa)
CENPJCentromere protein J. (1137 aa)
RAB11BRas-related protein Rab-11B. (204 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (747 aa)
ADAMTS1A disintegrin and metalloproteinase with thrombospondin motifs 1. (736 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (299 aa)
AIF1Leukocyte-specific transcript 1 protein. (191 aa)
RPTORLOW QUALITY PROTEIN: regulatory-associated protein of mTOR. (1411 aa)
CDC27Cell division cycle protein 27 homolog isoform X1. (825 aa)
CDC25CM-phase inducer phosphatase 3-like. (476 aa)
CDC23Cell division cycle protein 23 homolog isoform X1. (597 aa)
PLRG1Pleiotropic regulator 1 isoform X1. (515 aa)
ANAPC11Anaphase-promoting complex subunit 11. (84 aa)
DDX3XDEAD-box helicase 3 X-linked. (608 aa)
RRM2BLOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B. (351 aa)
CUL3Cullin-3; Belongs to the cullin family. (746 aa)
RB1Retinoblastoma-associated protein. (920 aa)
KMT2EHistone-lysine N-methyltransferase 2E. (1811 aa)
ABL1Tyrosine-protein kinase. (1135 aa)
PPP1R10LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 1 regulatory subunit 10. (952 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDC16Cell division cycle protein 16 homolog. (619 aa)
CCND1G1/S-specific cyclin-D1. (74 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa)
NANOGHomeobox protein NANOG isoform X1. (315 aa)
PHB2Prohibitin. (297 aa)
RRM2Ribonucleoside-diphosphate reductase subunit M2. (297 aa)
CPSF3Cleavage and polyadenylation specificity factor subunit 3. (647 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
EIF4EEukaryotic Translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
LGMNLegumain. (433 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
MAD2L1BPMAD2L1-binding protein. (282 aa)
CDCA5Cell division cycle associated 5. (253 aa)
SASS6Spindle assembly abnormal protein 6 homolog. (657 aa)
CDT1DNA replication factor Cdt1. (504 aa)
EGFRReceptor protein-tyrosine kinase. (1191 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (109 aa)
SMOC2SPARC-related modular calcium-binding protein 2. (423 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
RAD51BDNA repair protein RAD51 homolog 2 isoform X1. (271 aa)
PRAP1Proline-rich acidic protein 1 isoform X1. (160 aa)
DDX3YLOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (704 aa)
MBLAC1Metallo-beta-lactamase domain-containing protein 1. (269 aa)
MEPCE7SK snRNA methylphosphate capping enzyme. (635 aa)
SHBSH2 domain-containing adapter protein B. (348 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (237 aa)
POLDIP2DNA polymerase delta interacting protein 2. (404 aa)
RAB11ARAB11A, member RAS oncogene family. (216 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (173 aa)
MTA3Metastasis associated 1 family member 3. (537 aa)
SPHK1LOW QUALITY PROTEIN: sphingosine kinase 1. (387 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
FBXO5F-box only protein 5 isoform X2. (341 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (318 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa)
ANAPC5Anaphase-promoting complex subunit 5. (752 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
ANKRD17LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 17. (2527 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ANAPC7Anaphase-promoting complex subunit 7. (565 aa)
ENSUMAP00000002305annotation not available (122 aa)
ENSUMAP00000010476annotation not available (668 aa)
STOX1Storkhead-box protein 1. (925 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
DTLDenticleless protein homolog. (770 aa)
TFDP1Transcription factor Dp-1. (412 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
MECP2methyl-CpG-binding protein 2. (172 aa)
PKN2Serine/threonine-protein kinase N2. (944 aa)
LSM10U7 snRNA-associated Sm-like protein LSm10. (217 aa)
CDC7LOW QUALITY PROTEIN: cell division cycle 7-related protein kinase. (569 aa)
CDC25AM-phase inducer phosphatase 1. (518 aa)
HES1Transcription factor HES-1. (166 aa)
RCC2Protein RCC2. (505 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (561 aa)
MTBPMdm2-binding protein isoform X1. (904 aa)
ANXA1Annexin. (345 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3418 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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