STRINGSTRING
PTPN11 PTPN11 FGF21 FGF21 CREBL2 CREBL2 ADIPOQ ADIPOQ INS-IGF2 INS-IGF2 FGF19 FGF19 PIK3R1 PIK3R1 CAPN10 CAPN10 PRKCI PRKCI OPN3 OPN3 AKT3 AKT3 GPC3 GPC3 RHOQ RHOQ INSR INSR NFE2L2 NFE2L2 RNASEL RNASEL PTH PTH SLC1A2 SLC1A2 IGF1 IGF1 AKT2 AKT2 APPL1 APPL1 OSBPL8 OSBPL8 AKT1 AKT1 MEF2A MEF2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
CREBL2cAMP-responsive element-binding protein-like 2. (120 aa)
ADIPOQAdiponectin isoform X2. (297 aa)
INS-IGF2Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (199 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
CAPN10Calpain-10; Belongs to the peptidase C2 family. (636 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (569 aa)
OPN3Opsin-3; Belongs to the G-protein coupled receptor 1 family. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (625 aa)
RHOQRho-related GTP-binding protein RhoQ. (210 aa)
INSRTyrosine-protein kinase receptor. (1375 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X2. (590 aa)
RNASEL2-5A-dependent ribonuclease. (725 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
SLC1A2Amino acid transporter. (599 aa)
IGF1Insulin-like growth factor I isoform X1. (184 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
APPL1DCC-interacting protein 13-alpha. (656 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (873 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
MEF2AMyocyte-specific enhancer factor 2A. (466 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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