(12 nodes) Sympathetic nervous system development network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	PHOX2B	Paired mesoderm homeobox protein 2B. (187 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	CTNNB1	Catenin beta-1. (787 aa)
	TFAP2B	Transcription factor AP-2-beta. (460 aa)
	TFAP2E	Transcription factor AP-2-epsilon. (416 aa)
	GDNF	Glial cell line-derived neurotrophic factor. (241 aa)
	NF1	Neurofibromin. (2862 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	GFRA3	GDNF family receptor alpha-3. (395 aa)
	SEMA3F	semaphorin-3F; Belongs to the semaphorin family. (578 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (926 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	FZD3	ENSUMAP00000005500	ENSUMAP00000031112	Catenin beta-1.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.711
FZD3	CTNNB1	ENSUMAP00000031112	ENSUMAP00000005500	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Catenin beta-1.	0.711
GDNF	GFRA3	ENSUMAP00000010972	ENSUMAP00000022187	Glial cell line-derived neurotrophic factor.	GDNF family receptor alpha-3.	0.839
GFRA3	GDNF	ENSUMAP00000022187	ENSUMAP00000010972	GDNF family receptor alpha-3.	Glial cell line-derived neurotrophic factor.	0.839
NRP2	SEMA3F	ENSUMAP00000031095	ENSUMAP00000030468	Neuropilin; Belongs to the neuropilin family.	semaphorin-3F; Belongs to the semaphorin family.	0.999
SEMA3F	NRP2	ENSUMAP00000030468	ENSUMAP00000031095	semaphorin-3F; Belongs to the semaphorin family.	Neuropilin; Belongs to the neuropilin family.	0.999