27 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HES1	Transcription factor HES-1. (166 aa)
	ENSUMAP00000002583	annotation not available (205 aa)
	CACNB4	Voltage-dependent L-type calcium channel subunit beta-4. (501 aa)
	MAPK1	Mitogen-activated protein kinase. (363 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	PAX1	Paired box protein Pax-1. (357 aa)
	EPHB3	Ephrin type-B receptor 3. (930 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	MAD1L1	LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD1. (706 aa)
	FADD	FAS-associated death domain protein. (192 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
	SRF	Serum response factor. (446 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	BCL2L11	Bcl-2-like protein 11 isoform X11. (84 aa)
	FOXN1	LOW QUALITY PROTEIN: forkhead box protein N1. (628 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	ZBTB1	Zinc finger and BTB domain-containing protein 1. (644 aa)
	ENSUMAP00000018722	annotation not available (372 aa)
	BRAF	Serine/threonine-protein kinase B-raf. (715 aa)
	ZMPSTE24	Zinc metallopeptidase STE24. (276 aa)
	CTC1	LOW QUALITY PROTEIN: CST complex subunit CTC1. (1247 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
	JARID2	LOW QUALITY PROTEIN: protein Jumonji. (1137 aa)
	ABL1	Tyrosine-protein kinase. (1135 aa)
	SLC46A2	Thymic stromal cotransporter homolog. (468 aa)
	RIPK3	Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. (487 aa)
	ASXL1	Putative Polycomb group protein ASXL1. (1509 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ATM	ENSUMAP00000025680	ENSUMAP00000011132	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.849
ABL1	CRKL	ENSUMAP00000025680	ENSUMAP00000004513	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.981
ABL1	EPHB3	ENSUMAP00000025680	ENSUMAP00000006660	Tyrosine-protein kinase.	Ephrin type-B receptor 3.	0.916
ABL1	MAPK1	ENSUMAP00000025680	ENSUMAP00000004216	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.437
ABL1	MAPK3	ENSUMAP00000025680	ENSUMAP00000014967	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.437
ASXL1	JARID2	ENSUMAP00000033551	ENSUMAP00000024315	Putative Polycomb group protein ASXL1.	LOW QUALITY PROTEIN: protein Jumonji.	0.479
ATM	ABL1	ENSUMAP00000011132	ENSUMAP00000025680	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.849
ATM	BRAF	ENSUMAP00000011132	ENSUMAP00000020492	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase B-raf.	0.554
BRAF	ATM	ENSUMAP00000020492	ENSUMAP00000011132	Serine/threonine-protein kinase B-raf.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.554
BRAF	MAPK1	ENSUMAP00000020492	ENSUMAP00000004216	Serine/threonine-protein kinase B-raf.	Mitogen-activated protein kinase.	0.851
BRAF	MAPK3	ENSUMAP00000020492	ENSUMAP00000014967	Serine/threonine-protein kinase B-raf.	Mitogen-activated protein kinase.	0.850
BRAF	RAF1	ENSUMAP00000020492	ENSUMAP00000024161	Serine/threonine-protein kinase B-raf.	RAF proto-oncogene serine/threonine-protein kinase.	0.994
CRKL	ABL1	ENSUMAP00000004513	ENSUMAP00000025680	CRK like proto-oncogene, adaptor protein.	Tyrosine-protein kinase.	0.981
EPHB3	ABL1	ENSUMAP00000006660	ENSUMAP00000025680	Ephrin type-B receptor 3.	Tyrosine-protein kinase.	0.916
FADD	RIPK3	ENSUMAP00000009429	ENSUMAP00000031815	FAS-associated death domain protein.	Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily.	0.994
FOXN1	PAX1	ENSUMAP00000016255	ENSUMAP00000005058	LOW QUALITY PROTEIN: forkhead box protein N1.	Paired box protein Pax-1.	0.705
JARID2	ASXL1	ENSUMAP00000024315	ENSUMAP00000033551	LOW QUALITY PROTEIN: protein Jumonji.	Putative Polycomb group protein ASXL1.	0.479
MAPK1	ABL1	ENSUMAP00000004216	ENSUMAP00000025680	Mitogen-activated protein kinase.	Tyrosine-protein kinase.	0.437
MAPK1	BRAF	ENSUMAP00000004216	ENSUMAP00000020492	Mitogen-activated protein kinase.	Serine/threonine-protein kinase B-raf.	0.851
MAPK1	MAPK3	ENSUMAP00000004216	ENSUMAP00000014967	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.992