(20 nodes) Digestive tract morphogenesis network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NIPBL	Nipped-B protein. (2805 aa)
	GLI3	Transcriptional activator GLI3. (524 aa)
	NODAL	Nodal homolog. (271 aa)
	FOXF1	Forkhead box protein F1. (370 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	EPHB3	Ephrin type-B receptor 3. (930 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	SHH	Sonic hedgehog protein. (168 aa)
	SOX10	Transcription factor SOX-10. (305 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SFRP2	Secreted frizzled-related protein 2. (299 aa)
	IHH	Indian hedgehog protein. (145 aa)
	AGR2	Anterior gradient protein 2 homolog. (167 aa)
	AHI1	LOW QUALITY PROTEIN: jouberin. (1133 aa)
	TCF21	Transcription factor 21. (179 aa)
	SFRP1	Secreted frizzled-related protein 1. (305 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform X2. (823 aa)
	STRA6	LOW QUALITY PROTEIN: stimulated by retinoic acid gene 6 protein homolog. (630 aa)
	SMAD3	Mothers against decapentaplegic homolog. (280 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGF10	ENSUMAP00000021648	ENSUMAP00000007657	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.817
BMP4	FOXF1	ENSUMAP00000021648	ENSUMAP00000010285	Bone morphogenetic protein 4.	Forkhead box protein F1.	0.505
BMP4	IHH	ENSUMAP00000021648	ENSUMAP00000026096	Bone morphogenetic protein 4.	Indian hedgehog protein.	0.786
BMP4	PDGFRA	ENSUMAP00000021648	ENSUMAP00000004437	Bone morphogenetic protein 4.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.546
BMP4	SMAD3	ENSUMAP00000021648	ENSUMAP00000016415	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.684
BMP4	SOX10	ENSUMAP00000021648	ENSUMAP00000020540	Bone morphogenetic protein 4.	Transcription factor SOX-10.	0.453
FGF10	BMP4	ENSUMAP00000007657	ENSUMAP00000021648	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.817
FGF10	HIF1A	ENSUMAP00000007657	ENSUMAP00000018657	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hypoxia-inducible factor 1-alpha isoform X2.	0.448
FGF10	IHH	ENSUMAP00000007657	ENSUMAP00000026096	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Indian hedgehog protein.	0.849
FGF10	PDGFRA	ENSUMAP00000007657	ENSUMAP00000004437	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.872
FOXF1	BMP4	ENSUMAP00000010285	ENSUMAP00000021648	Forkhead box protein F1.	Bone morphogenetic protein 4.	0.505
FOXF1	GLI3	ENSUMAP00000010285	ENSUMAP00000013368	Forkhead box protein F1.	Transcriptional activator GLI3.	0.488
FOXF1	IHH	ENSUMAP00000010285	ENSUMAP00000026096	Forkhead box protein F1.	Indian hedgehog protein.	0.424
FOXF1	TCF21	ENSUMAP00000010285	ENSUMAP00000033871	Forkhead box protein F1.	Transcription factor 21.	0.418
GLI3	FOXF1	ENSUMAP00000013368	ENSUMAP00000010285	Transcriptional activator GLI3.	Forkhead box protein F1.	0.488
GLI3	IHH	ENSUMAP00000013368	ENSUMAP00000026096	Transcriptional activator GLI3.	Indian hedgehog protein.	0.690
GLI3	PDGFRA	ENSUMAP00000013368	ENSUMAP00000004437	Transcriptional activator GLI3.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.600
HIF1A	FGF10	ENSUMAP00000018657	ENSUMAP00000007657	Hypoxia-inducible factor 1-alpha isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.448
HIF1A	SMAD3	ENSUMAP00000018657	ENSUMAP00000016415	Hypoxia-inducible factor 1-alpha isoform X2.	Mothers against decapentaplegic homolog.	0.730
IHH	BMP4	ENSUMAP00000026096	ENSUMAP00000021648	Indian hedgehog protein.	Bone morphogenetic protein 4.	0.786