65 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCDC142	Coiled-coil domain-containing protein 142. (584 aa)
	PDGFB	Platelet-derived growth factor subunit B. (234 aa)
	ADAMTS1	A disintegrin and metalloproteinase with thrombospondin motifs 1. (736 aa)
	NF1	Neurofibromin. (2862 aa)
	AIF1	Leukocyte-specific transcript 1 protein. (191 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	HBEGF	Proheparin-binding EGF-like growth factor. (201 aa)
	PHB	Prohibitin. (265 aa)
	CDH13	Cadherin-13 isoform X1. (713 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	RNASE4	Ribonuclease 4 isoform X1; Belongs to the pancreatic ribonuclease family. (319 aa)
	HMOX1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (264 aa)
	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1. (1029 aa)
	MEF2D	LOW QUALITY PROTEIN: myocyte-specific enhancer factor 2D. (494 aa)
	EDN1	Endothelin-1. (202 aa)
	SULF1	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (886 aa)
	CALCRL	Calcitonin gene-related peptide type 1 receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (463 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (658 aa)
	LDLRAP1	Low density lipoprotein receptor adapter protein 1. (296 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (567 aa)
	CNN1	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (273 aa)
	IGFBP5	Insulin-like growth factor-binding protein 5. (271 aa)
	XRCC5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	XRCC6	X-ray repair cross-complementing protein 6 isoform X1. (607 aa)
	NDRG4	Protein NDRG4 isoform X1. (356 aa)
	ENSUMAP00000029443	annotation not available (123 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	MFN2	Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
	TRIB1	Tribbles homolog 1. (191 aa)
	PDCD4	Programmed cell death protein 4. (469 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (714 aa)
	FOXP1	Forkhead box protein P1. (679 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	VIP	Vasoactive intestinal peptide. (170 aa)
	TCF7L2	Transcription factor 7-like 2. (587 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1493 aa)
	IL10	Interleukin-10. (178 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	THBS1	LOW QUALITY PROTEIN: thrombospondin-1. (1168 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
	ENSUMAP00000015139	annotation not available (194 aa)
	PRKG1	cGMP-dependent protein kinase 1. (472 aa)
	P2RY6	P2Y purinoceptor 6. (325 aa)
	IGFBP3	Insulin-like growth factor-binding protein 3. (102 aa)
	SERPINF2	LOW QUALITY PROTEIN: alpha-2-antiplasmin; Belongs to the serpin family. (402 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4135 aa)
	ENSUMAP00000010696	annotation not available (246 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	GPER1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	ELANE	Neutrophil elastase. (269 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform X3. (433 aa)
	BMP2	Bone morphogenetic protein 2 isoform X2. (395 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1152 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	CTNNB1	Catenin beta-1. (787 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	ADIPOQ	Adiponectin isoform X2. (297 aa)
	PPARGC1A	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha. (784 aa)
	NDRG2	Protein NDRG2 isoform X1. (376 aa)
	FOXJ2	Forkhead box protein J2. (547 aa)
	APOD	Apolipoprotein D. (183 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (185 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS1	HBEGF	ENSUMAP00000020254	ENSUMAP00000021015	A disintegrin and metalloproteinase with thrombospondin motifs 1.	Proheparin-binding EGF-like growth factor.	0.446
ADIPOQ	CDH13	ENSUMAP00000005319	ENSUMAP00000021435	Adiponectin isoform X2.	Cadherin-13 isoform X1.	0.510
ADIPOQ	IFNG	ENSUMAP00000005319	ENSUMAP00000028473	Adiponectin isoform X2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.440
ADIPOQ	IL10	ENSUMAP00000005319	ENSUMAP00000035264	Adiponectin isoform X2.	Interleukin-10.	0.636
ADIPOQ	PPARGC1A	ENSUMAP00000005319	ENSUMAP00000004473	Adiponectin isoform X2.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha.	0.641
ADIPOQ	TLR4	ENSUMAP00000005319	ENSUMAP00000005351	Adiponectin isoform X2.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.468
ADIPOQ	TNF	ENSUMAP00000005319	ENSUMAP00000020603	Adiponectin isoform X2.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.590
BMP2	BMP4	ENSUMAP00000006638	ENSUMAP00000021648	Bone morphogenetic protein 2 isoform X2.	Bone morphogenetic protein 4.	0.928
BMP2	BMPR1A	ENSUMAP00000006638	ENSUMAP00000019489	Bone morphogenetic protein 2 isoform X2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.999
BMP2	BMPR2	ENSUMAP00000006638	ENSUMAP00000030219	Bone morphogenetic protein 2 isoform X2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.991
BMP2	CTNNB1	ENSUMAP00000006638	ENSUMAP00000005500	Bone morphogenetic protein 2 isoform X2.	Catenin beta-1.	0.535
BMP2	FGF2	ENSUMAP00000006638	ENSUMAP00000005828	Bone morphogenetic protein 2 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.729
BMP2	FGF9	ENSUMAP00000006638	ENSUMAP00000020627	Bone morphogenetic protein 2 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.527
BMP2	TNF	ENSUMAP00000006638	ENSUMAP00000020603	Bone morphogenetic protein 2 isoform X2.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.447
BMP4	BMP2	ENSUMAP00000021648	ENSUMAP00000006638	Bone morphogenetic protein 4.	Bone morphogenetic protein 2 isoform X2.	0.928
BMP4	BMPR1A	ENSUMAP00000021648	ENSUMAP00000019489	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.996
BMP4	BMPR2	ENSUMAP00000021648	ENSUMAP00000030219	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.991
BMP4	CTNNB1	ENSUMAP00000021648	ENSUMAP00000005500	Bone morphogenetic protein 4.	Catenin beta-1.	0.614
BMP4	FGF2	ENSUMAP00000021648	ENSUMAP00000005828	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.769
BMP4	FGF9	ENSUMAP00000021648	ENSUMAP00000020627	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.588