STRINGSTRING
BMI1 BMI1 ALX3 ALX3 WDR60 WDR60 UCMA UCMA SIX2 SIX2 TGFBR1 TGFBR1 SMAD3 SMAD3 TULP3 TULP3 GLI3 GLI3 NODAL NODAL FUZ FUZ SLC39A3 SLC39A3 MYF5 MYF5 SETD2 SETD2 PDGFRA PDGFRA TAPT1 TAPT1 DLG1 DLG1 MTHFD1L MTHFD1L ENSUMAP00000001989 ENSUMAP00000001989 HOXA9 HOXA9 HOXA6 HOXA6 ALX1 ALX1 WDR19 WDR19 MDFI MDFI NIPBL NIPBL HOXC6 HOXC6 DLX1 DLX1 SHH SHH MMP14 MMP14 SIX1 SIX1 ENSUMAP00000018722 ENSUMAP00000018722 KIAA1217 KIAA1217 SLC2A10 SLC2A10 SULF2 SULF2 DLG2 DLG2 OSR1 OSR1 MKS1 MKS1 ENSUMAP00000014261 ENSUMAP00000014261 MED12 MED12 LHX1 LHX1 PCSK5 PCSK5 IFT140 IFT140 SATB2 SATB2 EXT1 EXT1 SLC39A1 SLC39A1 DMRT2 DMRT2 IHH IHH RDH10 RDH10 ENSUMAP00000025747 ENSUMAP00000025747 EYA1 EYA1 CHST11 CHST11 SULF1 SULF1 TFAP2A TFAP2A FLVCR1 FLVCR1 PCGF2 PCGF2 OSR2 OSR2 ZEB1 ZEB1 BMP4 BMP4 HOXB1 HOXB1 HOXB5 HOXB5 HOXB7 HOXB7 LOC103661076 LOC103661076 EDNRA EDNRA HOXD4 HOXD4 HOXD10 HOXD10 ALX4 ALX4 WNT9B WNT9B SP3 SP3 MMP16 MMP16 FGF9 FGF9 EIF4A3 EIF4A3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMI1Polycomb complex protein BMI-1. (326 aa)
ALX3Homeobox protein aristaless-like 3. (371 aa)
WDR60WD repeat-containing protein 60 isoform X2. (959 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (138 aa)
SIX2LOW QUALITY PROTEIN: homeobox protein SIX2. (267 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
SMAD3Mothers against decapentaplegic homolog. (280 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (462 aa)
GLI3Transcriptional activator GLI3. (524 aa)
NODALNodal homolog. (271 aa)
FUZLOW QUALITY PROTEIN: protein fuzzy homolog. (373 aa)
SLC39A3Solute carrier family 39 member 3. (314 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
SETD2Histone-lysine N-methyltransferase SETD2. (2520 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
TAPT1Transmembrane anterior posterior transformation protein 1 homolog. (595 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
MTHFD1LMonofunctional C1-tetrahydrofolate synthase, mitochondrial. (759 aa)
ENSUMAP00000001989annotation not available (146 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
HOXA6Homeobox protein Hox-A6. (233 aa)
ALX1ALX homeobox protein 1. (326 aa)
WDR19WD repeat-containing protein 19. (1283 aa)
MDFImyoD family inhibitor. (277 aa)
NIPBLNipped-B protein. (2805 aa)
HOXC6Homeobox protein Hox-C6 isoform X2. (153 aa)
DLX1LOW QUALITY PROTEIN: homeobox protein DLX-1. (243 aa)
SHHSonic hedgehog protein. (168 aa)
MMP14Matrix metalloproteinase-14. (571 aa)
SIX1Homeobox protein SIX1. (284 aa)
ENSUMAP00000018722annotation not available (372 aa)
KIAA1217LOW QUALITY PROTEIN: sickle tail protein homolog. (1891 aa)
SLC2A10Solute carrier family 2, facilitated glucose transporter member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (597 aa)
SULF2Extracellular sulfatase Sulf-2. (803 aa)
DLG2Disks large homolog 2 isoform X1. (843 aa)
OSR1Protein odd-skipped-related 1. (272 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
ENSUMAP00000014261annotation not available (190 aa)
MED12LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 12. (2045 aa)
LHX1LOW QUALITY PROTEIN: LIM/homeobox protein Lhx1. (395 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (852 aa)
IFT140Intraflagellar transport protein 140 homolog isoform X1. (1459 aa)
SATB2DNA-binding protein SATB. (703 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (501 aa)
SLC39A1Solute carrier family 39 member 1. (324 aa)
DMRT2Doublesex- and mab-3-related transcription factor 2. (386 aa)
IHHIndian hedgehog protein. (145 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa)
ENSUMAP00000025747annotation not available (76 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
CHST11Carbohydrate sulfotransferase. (132 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (886 aa)
TFAP2ALOW QUALITY PROTEIN: transcription factor AP-2-alpha. (494 aa)
FLVCR1LOW QUALITY PROTEIN: feline leukemia virus subgroup C receptor-related protein 1. (448 aa)
PCGF2Polycomb group RING finger protein 2 isoform X1. (326 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
ZEB1Zinc finger E-box-binding homeobox 1. (1086 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
HOXB1Homeobox protein Hox-B1. (301 aa)
HOXB5Homeobox protein Hox-B5. (267 aa)
HOXB7Homeobox protein Hox-B7. (205 aa)
LOC103661076Homeobox protein Hox-B8-like. (134 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HOXD4Homeobox protein Hox-D4a-like. (182 aa)
HOXD10Homeobox protein Hox-D10. (340 aa)
ALX4Homeobox protein aristaless-like 4. (238 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SP3Transcription factor Sp3. (727 aa)
MMP16Matrix metalloproteinase-16. (609 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EIF4A3Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family. (426 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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