STRINGSTRING
SGCD SGCD ENG ENG TREX1 TREX1 MYLK2 MYLK2 ANKRD1 ANKRD1 PRKAR1A PRKAR1A LRRC10 LRRC10 TNNI1 TNNI1 NEB NEB PRMT1 PRMT1 LOC103665211 LOC103665211 PLN PLN WNT2 WNT2 PKP2 PKP2 HAND1 HAND1 SMAD4 SMAD4 TBX20 TBX20 PDGFRA PDGFRA ASB2 ASB2 ALPK2 ALPK2 BMP2 BMP2 MEF2C MEF2C SAV1 SAV1 PRKAR1B PRKAR1B ACADM ACADM ENSUMAP00000008347 ENSUMAP00000008347 MYL2 MYL2 MYLK3 MYLK3 VWA5A VWA5A ENSUMAP00000010815 ENSUMAP00000010815 SRF SRF MYBPC3 MYBPC3 MYL7 MYL7 ALPK3 ALPK3 GJA5 GJA5 TBX5 TBX5 TBX3 TBX3 TENM4 TENM4 SLC9A1 SLC9A1 IFT20 IFT20 MYL10 MYL10 PTEN PTEN DLL4 DLL4 DIPK2A DIPK2A TGFBR1 TGFBR1 RYR2 RYR2 HNRNPU HNRNPU LOC103664222 LOC103664222 NEBL NEBL ENSUMAP00000018354 ENSUMAP00000018354 XIRP2 XIRP2 ACTN2 ACTN2 CHD7 CHD7 ENSUMAP00000018664 ENSUMAP00000018664 LRP2 LRP2 BMPR1A BMPR1A GJC1 GJC1 CXADR CXADR MYH6 MYH6 CBY1 CBY1 MYO18B MYO18B FGF9 FGF9 SGCG SGCG SMAD1 SMAD1 EDNRA EDNRA BMP4 BMP4 GREM1 GREM1 ITGB1 ITGB1 WNT8A WNT8A TSC1 TSC1 ZMPSTE24 ZMPSTE24 MED1 MED1 TCAP TCAP JARID2 JARID2 PROX1 PROX1 LMNA LMNA DSP DSP NDUFV2 NDUFV2 RARB RARB ENSUMAP00000025822 ENSUMAP00000025822 CAV3 CAV3 FOXH1 FOXH1 ZFPM2 ZFPM2 ATG5 ATG5 CSRP3 CSRP3 SGCZ SGCZ ENSUMAP00000028318 ENSUMAP00000028318 TGFB2 TGFB2 FHL2 FHL2 ADPRHL1 ADPRHL1 BVES BVES NPRL3 NPRL3 ENSUMAP00000029024 ENSUMAP00000029024 BMP10 BMP10 TNNC1 TNNC1 ENSUMAP00000030969 ENSUMAP00000030969 MTOR MTOR ALDH1A2 ALDH1A2 NOX4 NOX4 MAML1 MAML1 ARID2 ARID2 NRAP NRAP MEF2A MEF2A HEG1 HEG1 ADPRH ADPRH SIK1 SIK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SGCDDelta-sarcoglycan isoform X1. (289 aa)
ENGEndoglin. (609 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (607 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (409 aa)
LRRC10Leucine-rich repeat-containing protein 10. (279 aa)
TNNI1LOW QUALITY PROTEIN: troponin I, slow skeletal muscle. (185 aa)
NEBNebulin. (7078 aa)
PRMT1Protein arginine N-methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (286 aa)
LOC103665211Mothers against decapentaplegic homolog. (244 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
PKP2Plakophilin-2. (839 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (62 aa)
SMAD4Mothers against decapentaplegic homolog. (546 aa)
TBX20T-box transcription factor TBX20. (447 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ASB2LOW QUALITY PROTEIN: ankyrin repeat and SOCS box protein 2. (512 aa)
ALPK2Alpha-protein kinase 2. (2103 aa)
BMP2Bone morphogenetic protein 2 isoform X2. (395 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X3. (433 aa)
SAV1Salvador family WW domain containing protein 1. (351 aa)
PRKAR1BLOW QUALITY PROTEIN: cAMP-dependent protein kinase type I-beta regulatory subunit. (412 aa)
ACADMLOW QUALITY PROTEIN: medium-chain specific acyl-CoA dehydrogenase, mitochondrial. (233 aa)
ENSUMAP00000008347annotation not available (104 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (205 aa)
MYLK3Myosin light chain kinase 3. (815 aa)
VWA5AVon Willebrand factor A domain-containing protein 5A isoform X2. (784 aa)
ENSUMAP00000010815annotation not available (220 aa)
SRFSerum response factor. (446 aa)
MYBPC3LOW QUALITY PROTEIN: myosin-binding protein C, cardiac-type. (1236 aa)
MYL7Myosin regulatory light chain 2, atrial isoform. (175 aa)
ALPK3LOW QUALITY PROTEIN: alpha-protein kinase 3. (229 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
TBX5T-box transcription factor TBX5. (474 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (130 aa)
TENM4Teneurin-4-like. (2643 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (813 aa)
IFT20Intraflagellar transport protein 20 homolog. (132 aa)
MYL10Myosin regulatory light chain 10. (217 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
DIPK2ADeleted in autism protein 1. (290 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
RYR2Ryanodine receptor 2. (4923 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (767 aa)
LOC103664222LIM zinc-binding domain-containing Nebulette-like. (272 aa)
NEBLNebulette. (705 aa)
ENSUMAP00000018354annotation not available (156 aa)
XIRP2Xin actin-binding repeat-containing protein 2 isoform X1. (3767 aa)
ACTN2LOW QUALITY PROTEIN: alpha-actinin-2. (859 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2976 aa)
ENSUMAP00000018664annotation not available (401 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (403 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
CXADRCoxsackievirus and adenovirus receptor isoform X2. (343 aa)
MYH6LOW QUALITY PROTEIN: myosin-6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1909 aa)
CBY1Chibby family member 1, beta catenin antagonist. (132 aa)
MYO18BUnconventional myosin-XVIIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2536 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SGCGGamma-sarcoglycan isoform X1. (309 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GREM1Gremlin. (232 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (326 aa)
TSC1Hamartin. (1168 aa)
ZMPSTE24Zinc metallopeptidase STE24. (276 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
TCAPTelethonin. (167 aa)
JARID2LOW QUALITY PROTEIN: protein Jumonji. (1137 aa)
PROX1Prospero homeobox protein 1. (737 aa)
LMNALamin A/C. (576 aa)
DSPDesmoplakin. (2828 aa)
NDUFV2NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial. (249 aa)
RARBRetinoic acid receptor beta-like. (441 aa)
ENSUMAP00000025822annotation not available (158 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
FOXH1Forkhead box protein H1 isoform X1. (370 aa)
ZFPM2Zinc finger protein ZFPM2. (1193 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
CSRP3Cysteine and glycine-rich protein 3. (194 aa)
SGCZZeta-sarcoglycan. (307 aa)
ENSUMAP00000028318annotation not available (80 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
FHL2Four and a half LIM domains protein 2. (279 aa)
ADPRHL1[Protein ADP-ribosylarginine] hydrolase-like protein 1 isoform X2. (354 aa)
BVESBlood vessel epicardial substance. (360 aa)
NPRL3Nitrogen permease regulator 3-like protein isoform X2. (594 aa)
ENSUMAP00000029024annotation not available (419 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (188 aa)
ENSUMAP00000030969annotation not available (251 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2531 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X2; Belongs to the aldehyde dehydrogenase family. (521 aa)
NOX4NADPH oxidase 4. (578 aa)
MAML1LOW QUALITY PROTEIN: mastermind-like protein 1. (789 aa)
ARID2LOW QUALITY PROTEIN: AT-rich interactive domain-containing protein 2. (1411 aa)
NRAPNebulin-related-anchoring protein. (1723 aa)
MEF2AMyocyte-specific enhancer factor 2A. (466 aa)
HEG1LOW QUALITY PROTEIN: protein HEG homolog 1. (138 aa)
ADPRHADP-ribosylarginine hydrolase. (362 aa)
SIK1Serine/threonine-protein kinase SIK1. (678 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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