(18 nodes) Smooth muscle tissue development network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NF1	Neurofibromin. (2862 aa)
	ENG	Endoglin. (609 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
	PKD2	Polycystin-2. (831 aa)
	STRA6	LOW QUALITY PROTEIN: stimulated by retinoic acid gene 6 protein homolog. (630 aa)
	SMO	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (745 aa)
	SRF	Serum response factor. (446 aa)
	PTCH1	Protein patched homolog 1. (1388 aa)
	SCHIP1	Schwannomin-interacting protein 1 isoform X1. (260 aa)
	TIPARP	TCDD-inducible poly [ADP-ribose] polymerase. (657 aa)
	SHH	Sonic hedgehog protein. (168 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	PROX1	Prospero homeobox protein 1. (737 aa)
	COL3A1	Collagen alpha-1(III) chain. (762 aa)
	IHH	Indian hedgehog protein. (145 aa)
	ZFAND5	Zinc finger AN1-type containing 5. (213 aa)
	OSR1	Protein odd-skipped-related 1. (272 aa)
	DLG2	Disks large homolog 2 isoform X1. (843 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	IHH	ENSUMAP00000021648	ENSUMAP00000026096	Bone morphogenetic protein 4.	Indian hedgehog protein.	0.786
BMP4	PTCH1	ENSUMAP00000021648	ENSUMAP00000013120	Bone morphogenetic protein 4.	Protein patched homolog 1.	0.525
DLG1	DLG2	ENSUMAP00000003680	ENSUMAP00000033110	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Disks large homolog 2 isoform X1.	0.901
DLG2	DLG1	ENSUMAP00000033110	ENSUMAP00000003680	Disks large homolog 2 isoform X1.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.901
IHH	BMP4	ENSUMAP00000026096	ENSUMAP00000021648	Indian hedgehog protein.	Bone morphogenetic protein 4.	0.786
IHH	PTCH1	ENSUMAP00000026096	ENSUMAP00000013120	Indian hedgehog protein.	Protein patched homolog 1.	0.993
IHH	SMO	ENSUMAP00000026096	ENSUMAP00000009273	Indian hedgehog protein.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.833
PKD2	SMO	ENSUMAP00000005399	ENSUMAP00000009273	Polycystin-2.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.512
PTCH1	BMP4	ENSUMAP00000013120	ENSUMAP00000021648	Protein patched homolog 1.	Bone morphogenetic protein 4.	0.525
PTCH1	IHH	ENSUMAP00000013120	ENSUMAP00000026096	Protein patched homolog 1.	Indian hedgehog protein.	0.993
PTCH1	SHH	ENSUMAP00000013120	ENSUMAP00000019678	Protein patched homolog 1.	Sonic hedgehog protein.	0.811
PTCH1	SMO	ENSUMAP00000013120	ENSUMAP00000009273	Protein patched homolog 1.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.998
SCHIP1	TIPARP	ENSUMAP00000015245	ENSUMAP00000015606	Schwannomin-interacting protein 1 isoform X1.	TCDD-inducible poly [ADP-ribose] polymerase.	0.583
SCHIP1	ZFAND5	ENSUMAP00000015245	ENSUMAP00000030345	Schwannomin-interacting protein 1 isoform X1.	Zinc finger AN1-type containing 5.	0.785
SHH	PTCH1	ENSUMAP00000019678	ENSUMAP00000013120	Sonic hedgehog protein.	Protein patched homolog 1.	0.811
SHH	SMO	ENSUMAP00000019678	ENSUMAP00000009273	Sonic hedgehog protein.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.568
SMO	IHH	ENSUMAP00000009273	ENSUMAP00000026096	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	Indian hedgehog protein.	0.833
SMO	PKD2	ENSUMAP00000009273	ENSUMAP00000005399	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	Polycystin-2.	0.512
SMO	PTCH1	ENSUMAP00000009273	ENSUMAP00000013120	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein patched homolog 1.	0.998
SMO	SHH	ENSUMAP00000009273	ENSUMAP00000019678	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	Sonic hedgehog protein.	0.568