(22 nodes) Erythrocyte development network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERCC2	LOW QUALITY PROTEIN: TFIIH basal transcription factor complex helicase XPD subunit. (600 aa)
	LYAR	Cell growth-regulating nucleolar protein. (387 aa)
	L3MBTL3	Lethal(3)malignant brain tumor-like protein 3 isoform X2. (755 aa)
	BCL6	B-cell lymphoma 6 protein isoform X1. (706 aa)
	PLA2G10	Phospholipase A(2). (157 aa)
	ABCB10	ATP-binding cassette sub-family B member 10, mitochondrial. (545 aa)
	ADGRF5	Probable G-protein coupled receptor 116 isoform X3; Belongs to the G-protein coupled receptor 2 family. (1346 aa)
	MAEA	Macrophage erythroblast attacher. (245 aa)
	DMTN	Dematin. (371 aa)
	SH2B3	SH2B adapter protein 3. (368 aa)
	GATA1	LOW QUALITY PROTEIN: erythroid transcription factor. (438 aa)
	SRF	Serum response factor. (446 aa)
	EPB42	Erythrocyte membrane protein band 4.2. (362 aa)
	EPO	LOW QUALITY PROTEIN: erythropoietin. (192 aa)
	NCKAP1L	Nck-associated protein 1-like. (1134 aa)
	JMJD6	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6. (314 aa)
	SLC4A1	Anion exchange protein. (924 aa)
	ARID4A	AT-rich interactive domain-containing protein 4A isoform X3. (1286 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
	FLVCR1	LOW QUALITY PROTEIN: feline leukemia virus subgroup C receptor-related protein 1. (448 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase. (451 aa)
	BAP1	Ubiquitin carboxyl-terminal hydrolase. (741 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB10	FLVCR1	ENSUMAP00000005963	ENSUMAP00000024767	ATP-binding cassette sub-family B member 10, mitochondrial.	LOW QUALITY PROTEIN: feline leukemia virus subgroup C receptor-related protein 1.	0.400
DMTN	EPB42	ENSUMAP00000009164	ENSUMAP00000013062	Dematin.	Erythrocyte membrane protein band 4.2.	0.622
DMTN	SLC4A1	ENSUMAP00000009164	ENSUMAP00000018760	Dematin.	Anion exchange protein.	0.421
EPB42	DMTN	ENSUMAP00000013062	ENSUMAP00000009164	Erythrocyte membrane protein band 4.2.	Dematin.	0.622
EPB42	GATA1	ENSUMAP00000013062	ENSUMAP00000010218	Erythrocyte membrane protein band 4.2.	LOW QUALITY PROTEIN: erythroid transcription factor.	0.489
EPB42	SLC4A1	ENSUMAP00000013062	ENSUMAP00000018760	Erythrocyte membrane protein band 4.2.	Anion exchange protein.	0.995
EPO	GATA1	ENSUMAP00000014808	ENSUMAP00000010218	LOW QUALITY PROTEIN: erythropoietin.	LOW QUALITY PROTEIN: erythroid transcription factor.	0.534
ERCC2	MED1	ENSUMAP00000032705	ENSUMAP00000023808	LOW QUALITY PROTEIN: TFIIH basal transcription factor complex helicase XPD subunit.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.524
FLVCR1	ABCB10	ENSUMAP00000024767	ENSUMAP00000005963	LOW QUALITY PROTEIN: feline leukemia virus subgroup C receptor-related protein 1.	ATP-binding cassette sub-family B member 10, mitochondrial.	0.400
GATA1	EPB42	ENSUMAP00000010218	ENSUMAP00000013062	LOW QUALITY PROTEIN: erythroid transcription factor.	Erythrocyte membrane protein band 4.2.	0.489
GATA1	EPO	ENSUMAP00000010218	ENSUMAP00000014808	LOW QUALITY PROTEIN: erythroid transcription factor.	LOW QUALITY PROTEIN: erythropoietin.	0.534
GATA1	SLC4A1	ENSUMAP00000010218	ENSUMAP00000018760	LOW QUALITY PROTEIN: erythroid transcription factor.	Anion exchange protein.	0.404
MED1	ERCC2	ENSUMAP00000023808	ENSUMAP00000032705	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	LOW QUALITY PROTEIN: TFIIH basal transcription factor complex helicase XPD subunit.	0.524
SLC4A1	DMTN	ENSUMAP00000018760	ENSUMAP00000009164	Anion exchange protein.	Dematin.	0.421
SLC4A1	EPB42	ENSUMAP00000018760	ENSUMAP00000013062	Anion exchange protein.	Erythrocyte membrane protein band 4.2.	0.995
SLC4A1	GATA1	ENSUMAP00000018760	ENSUMAP00000010218	Anion exchange protein.	LOW QUALITY PROTEIN: erythroid transcription factor.	0.404