STRINGSTRING
ZP4 ZP4 SLAMF1 SLAMF1 ENSUMAP00000000296 ENSUMAP00000000296 IL12B IL12B HES1 HES1 EFNB1 EFNB1 RASAL3 RASAL3 CD3E CD3E CD38 CD38 KITLG KITLG TFRC TFRC CD74 CD74 BCL6 BCL6 SPTA1 SPTA1 TLR4 TLR4 IL2 IL2 IL27RA IL27RA IL21 IL21 SASH3 SASH3 VTCN1 VTCN1 PPP3CA PPP3CA HHLA2 HHLA2 MEF2C MEF2C MYD88 MYD88 FGF10 FGF10 LEP LEP CD81 CD81 IL12RB2 IL12RB2 IL18 IL18 FOXP3 FOXP3 DHPS DHPS FADD FADD CARD11 CARD11 TMIGD2 TMIGD2 IL6ST IL6ST IL12RB1 IL12RB1 AGER AGER CD40LG CD40LG RPS3 RPS3 CORO1A CORO1A TNFSF9 TNFSF9 NCKAP1L NCKAP1L LOC103668179 LOC103668179 CD6 CD6 IL2RA IL2RA CLCF1 CLCF1 VAV3 VAV3 PRKCQ PRKCQ ZP3 ZP3 LOC103665509 LOC103665509 BTNL2 BTNL2 PTPN22 PTPN22 ENSUMAP00000018377 ENSUMAP00000018377 BMI1 BMI1 PYCARD PYCARD CD320 CD320 IL7 IL7 ENSUMAP00000020575 ENSUMAP00000020575 NCK1 NCK1 AIF1 AIF1 IL15 IL15 ATAD5 ATAD5 RIPK2 RIPK2 SYK SYK PDCD1LG2 PDCD1LG2 CD274 CD274 IL23A IL23A SLC7A1 SLC7A1 HMGB1 HMGB1 TRAF6 TRAF6 TNFSF4 TNFSF4 IGFBP2 IGFBP2 NCK2 NCK2 PELI1 PELI1 ANXA1 ANXA1 CD28 CD28 TNFSF13B TNFSF13B STAT5B STAT5B GPAM GPAM NFATC2 NFATC2 GPR183 GPR183 STAT5A STAT5A TYK2 TYK2 ZNF335 ZNF335 CD86 CD86 CD80 CD80 PTPRC PTPRC ADA ADA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZP4Zona pellucida sperm-binding protein 4. (568 aa)
SLAMF1Signaling lymphocytic activation molecule isoform X2. (338 aa)
ENSUMAP00000000296annotation not available (97 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
HES1Transcription factor HES-1. (166 aa)
EFNB1ephrin-B1; Belongs to the ephrin family. (418 aa)
RASAL3RAS protein activator like-3. (879 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (201 aa)
CD38ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. (290 aa)
KITLGKit ligand. (274 aa)
TFRCTransferrin receptor protein 1 isoform X1. (770 aa)
CD74LOW QUALITY PROTEIN: HLA class II histocompatibility antigen gamma chain. (279 aa)
BCL6B-cell lymphoma 6 protein isoform X1. (706 aa)
SPTA1LOW QUALITY PROTEIN: spectrin alpha chain, erythrocytic 1. (2388 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
IL27RAInterleukin-27 receptor subunit alpha. (636 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
SASH3SAM and SH3 domain-containing protein 3. (321 aa)
VTCN1V-set domain-containing T-cell activation inhibitor 1. (275 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
HHLA2HERV-H LTR-associating protein 2. (395 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X3. (433 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
CD81Tetraspanin. (429 aa)
IL12RB2Interleukin-12 receptor subunit beta-2. (862 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (217 aa)
FOXP3Forkhead box protein P3. (314 aa)
DHPSDeoxyhypusine synthase. (369 aa)
FADDFAS-associated death domain protein. (192 aa)
CARD11Caspase recruitment domain-containing protein 11. (1215 aa)
TMIGD2Transmembrane and immunoglobulin domain-containing protein 2. (155 aa)
IL6STInterleukin-6 receptor subunit beta isoform X1. (918 aa)
IL12RB1LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1. (724 aa)
AGERAdvanced glycosylation end product-specific receptor. (311 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
TNFSF9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (212 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
LOC103668179LOW QUALITY PROTEIN: high mobility group protein B1-like. (200 aa)
CD6T-cell differentiation antigen CD6. (613 aa)
IL2RAInterleukin-2 receptor subunit alpha isoform X1. (267 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (215 aa)
VAV3Guanine nucleotide exchange factor VAV3. (782 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
ZP3Zona pellucida sperm-binding protein 3. (426 aa)
LOC103665509HLA class II histocompatibility antigen, DM beta chain. (280 aa)
BTNL2Butyrophilin-like protein 2. (147 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X2. (806 aa)
ENSUMAP00000018377annotation not available (92 aa)
BMI1Polycomb complex protein BMI-1. (326 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
CD320CD320 antigen. (347 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
ENSUMAP00000020575annotation not available (177 aa)
NCK1NCK adaptor protein 1. (244 aa)
AIF1Leukocyte-specific transcript 1 protein. (191 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
ATAD5ATPase family AAA domain-containing protein 5. (1847 aa)
RIPK2LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2. (512 aa)
SYKTyrosine-protein kinase SYK; Belongs to the protein kinase superfamily. Tyr protein kinase family. (610 aa)
PDCD1LG2LOW QUALITY PROTEIN: programmed cell death 1 ligand 2. (236 aa)
CD274Programmed cell death 1 ligand 1. (291 aa)
IL23AInterleukin-23 subunit alpha. (190 aa)
SLC7A1High affinity cationic amino acid transporter 1. (629 aa)
HMGB1High mobility group protein B1. (215 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
IGFBP2Insulin-like growth factor-binding protein 2. (228 aa)
NCK2Cytoplasmic protein. (380 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
ANXA1Annexin. (345 aa)
CD28T-cell-specific surface glycoprotein CD28. (277 aa)
TNFSF13BTumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (293 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (840 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2. (206 aa)
GPR183G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (357 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
TYK2Tyrosine-protein kinase. (1043 aa)
ZNF335Zinc finger protein 335. (1320 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (343 aa)
CD80T-lymphocyte activation antigen CD80. (302 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1268 aa)
ADAAdenosine deaminase isoform X4. (423 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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