STRINGSTRING
NF1 NF1 ENSUMAP00000020575 ENSUMAP00000020575 TNF TNF FGF9 FGF9 GDF2 GDF2 CDH13 CDH13 BMP4 BMP4 JCAD JCAD XBP1 XBP1 ITGB3 ITGB3 PTN PTN LOC103669173 LOC103669173 ITGA4 ITGA4 RTN4 RTN4 RNASE4 RNASE4 HMOX1 HMOX1 OSR2 OSR2 HTR2B HTR2B HMGB1 HMGB1 MED1 MED1 IQGAP3 IQGAP3 PROX1 PROX1 SCG2 SCG2 VASH2 VASH2 APLNR APLNR HPN HPN BMP6 BMP6 RREB1 RREB1 EYA1 EYA1 ENSUMAP00000025747 ENSUMAP00000025747 CDH3 CDH3 ESRP2 ESRP2 AKT2 AKT2 APELA APELA AGAP2 AGAP2 HSF4 HSF4 STXBP4 STXBP4 PRKCA PRKCA TGFA TGFA DLX6 DLX6 DLX5 DLX5 FZD7 FZD7 BMPR2 BMPR2 PDCD6 PDCD6 MST1 MST1 PDPK1 PDPK1 TGM1 TGM1 EGFL7 EGFL7 OSR1 OSR1 VEGFC VEGFC PRKD2 PRKD2 C5AR1 C5AR1 TNFAIP3 TNFAIP3 PIK3CD PIK3CD VIP VIP TCF7L2 TCF7L2 FLT4 FLT4 AKT1 AKT1 STAT5A STAT5A STAT3 STAT3 IL10 IL10 SFRP1 SFRP1 NOTCH2 NOTCH2 SRSF6 SRSF6 VEGFB VEGFB ST8SIA1 ST8SIA1 FGFBP1 FGFBP1 BAD BAD THBS4 THBS4 WNT2 WNT2 CLDN1 CLDN1 ECM1 ECM1 ODAM ODAM TP63 TP63 BMP5 BMP5 ZNF304 ZNF304 PKHD1 PKHD1 FGF2 FGF2 EGR3 EGR3 WDR48 WDR48 AGGF1 AGGF1 BMP2 BMP2 KDM5B KDM5B HRAS HRAS FGF10 FGF10 VEGFA VEGFA NOD2 NOD2 B4GALT1 B4GALT1 KDR KDR PRKD1 PRKD1 EPGN EPGN SMO SMO SIRT1 SIRT1 SIRT6 SIRT6 PDCL3 PDCL3 LRG1 LRG1 NODAL NODAL MYDGF MYDGF ENSUMAP00000010977 ENSUMAP00000010977 PGF PGF ENSUMAP00000010986 ENSUMAP00000010986 ACVRL1 ACVRL1 F3 F3 EGFR EGFR YAP1 YAP1 EMC10 EMC10 FPR2 FPR2 SP1 SP1 LOC103668179 LOC103668179 FGF1 FGF1 NRAS NRAS AKT3 AKT3 TGFBR1 TGFBR1 CCL24 CCL24 CCL26 CCL26 MTA3 MTA3 PROK1 PROK1 GRN GRN BMPR1A BMPR1A SHH SHH PDGFB PDGFB FGF7 FGF7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NF1Neurofibromin. (2862 aa)
ENSUMAP00000020575annotation not available (177 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GDF2Growth/differentiation factor 2. (402 aa)
CDH13Cadherin-13 isoform X1. (713 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
JCADJunctional protein associated with coronary artery disease. (1375 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (211 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (783 aa)
PTNPleiotrophin. (210 aa)
LOC103669173LOW QUALITY PROTEIN: GTPase HRas-like. (170 aa)
ITGA4Integrin alpha-4 isoform X2; Belongs to the integrin alpha chain family. (944 aa)
RTN4Reticulon. (978 aa)
RNASE4Ribonuclease 4 isoform X1; Belongs to the pancreatic ribonuclease family. (319 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (264 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
HMGB1High mobility group protein B1. (215 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
IQGAP3Ras GTPase-activating-like protein IQGAP3. (1601 aa)
PROX1Prospero homeobox protein 1. (737 aa)
SCG2Secretogranin-2. (578 aa)
VASH2Vasohibin-2 isoform X2. (345 aa)
APLNRApelin receptor. (330 aa)
HPNSerine protease hepsin; Belongs to the peptidase S1 family. (237 aa)
BMP6Bone morphogenetic protein 6. (364 aa)
RREB1LOW QUALITY PROTEIN: ras-responsive element-binding protein 1. (1176 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
ENSUMAP00000025747annotation not available (76 aa)
CDH3Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. (790 aa)
ESRP2Epithelial splicing regulatory protein 2. (616 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
AGAP2LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (754 aa)
HSF4Heat shock factor protein 4 isoform X1. (492 aa)
STXBP4Syntaxin-binding protein 4 isoform X2. (565 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
TGFAProtransforming growth factor alpha. (92 aa)
DLX6Homeobox protein DLX-6. (167 aa)
DLX5Homeobox protein DLX-5. (285 aa)
FZD7LOW QUALITY PROTEIN: frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (541 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PDCD6Programmed cell death protein 6. (185 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (680 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (572 aa)
TGM1Protein-glutamine gamma-glutamyltransferase K. (819 aa)
EGFL7Epidermal growth factor-like protein 7 isoform X3. (434 aa)
OSR1Protein odd-skipped-related 1. (272 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (436 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (833 aa)
C5AR1LOW QUALITY PROTEIN: C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (331 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (714 aa)
PIK3CDLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (855 aa)
VIPVasoactive intestinal peptide. (170 aa)
TCF7L2Transcription factor 7-like 2. (587 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1344 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
STAT3Signal transducer and activator of transcription. (838 aa)
IL10Interleukin-10. (178 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2444 aa)
SRSF6Serine/arginine-rich splicing factor 6. (215 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (167 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (255 aa)
BADBcl2-associated agonist of cell death. (168 aa)
THBS4Thrombospondin-4. (981 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ECM1LOW QUALITY PROTEIN: extracellular matrix protein 1. (473 aa)
ODAMOdontogenic ameloblast-associated protein isoform X2. (275 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
BMP5Bone morphogenetic protein 5 isoform X2. (454 aa)
ZNF304LOW QUALITY PROTEIN: zinc finger protein 304. (617 aa)
PKHD1LOW QUALITY PROTEIN: fibrocystin. (4039 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
EGR3Early growth response protein 3. (335 aa)
WDR48WD repeat-containing protein 48 isoform X1. (677 aa)
AGGF1Angiogenic factor with G patch and FHA domains 1. (714 aa)
BMP2Bone morphogenetic protein 2 isoform X2. (395 aa)
KDM5BLysine-specific demethylase 5B. (1493 aa)
HRASGTPase HRas isoform X1. (189 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (179 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (817 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (340 aa)
KDRLOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1344 aa)
PRKD1Serine/threonine-protein kinase D1. (874 aa)
EPGNEpithelial mitogen. (138 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (745 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X2. (446 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (329 aa)
PDCL3Phosducin-like protein 3. (240 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (347 aa)
NODALNodal homolog. (271 aa)
MYDGFUPF0556 protein C19orf10 homolog. (175 aa)
ENSUMAP00000010977annotation not available (77 aa)
PGFPlacenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (156 aa)
ENSUMAP00000010986annotation not available (61 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
F3Tissue factor. (295 aa)
EGFRReceptor protein-tyrosine kinase. (1191 aa)
YAP1LOW QUALITY PROTEIN: yorkie homolog. (457 aa)
EMC10ER membrane protein complex subunit 10. (241 aa)
FPR2N-formyl peptide receptor 2-like; Belongs to the G-protein coupled receptor 1 family. (351 aa)
SP1Sp1 transcription factor. (780 aa)
LOC103668179LOW QUALITY PROTEIN: high mobility group protein B1-like. (200 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
CCL26C-C motif chemokine. (93 aa)
MTA3Metastasis associated 1 family member 3. (537 aa)
PROK1Prokineticin-1. (105 aa)
GRNGranulins isoform X1. (724 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SHHSonic hedgehog protein. (168 aa)
PDGFBPlatelet-derived growth factor subunit B. (234 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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