STRINGSTRING
CASK CASK ALOX5 ALOX5 SFRP2 SFRP2 TRIM24 TRIM24 ZEB1 ZEB1 BMP4 BMP4 GDF2 GDF2 TNF TNF NF1 NF1 A4GNT A4GNT PEX2 PEX2 CNMD CNMD THBS1 THBS1 MMRN2 MMRN2 MUC16 MUC16 WDR77 WDR77 MAGED1 MAGED1 TNMD TNMD TGFBR1 TGFBR1 CD109 CD109 DLL4 DLL4 PTEN PTEN GPC3 GPC3 SFN SFN KDF1 KDF1 AQP11 AQP11 IFT80 IFT80 ATP5IF1 ATP5IF1 NUPR1 NUPR1 OVOL1 OVOL1 PPARD PPARD CDKN1A CDKN1A PTCH1 PTCH1 SYNJ2BP SYNJ2BP LOC103675515 LOC103675515 SERPINF1 SERPINF1 ACVRL1 ACVRL1 LIMS2 LIMS2 B2M B2M VASH1 VASH1 WNT10B WNT10B SNAI2 SNAI2 B4GALT1 B4GALT1 STK11 STK11 IFT74 IFT74 LOC103677394 LOC103677394 CDKN2B CDKN2B SAV1 SAV1 MEF2C MEF2C IFT57 IFT57 GDF5 GDF5 FLCN FLCN DAB2IP DAB2IP PHB2 PHB2 DLG1 DLG1 PDCD10 PDCD10 ATP5F1A ATP5F1A CDKN1B CDKN1B CAV1 CAV1 CAV2 CAV2 PHOX2B PHOX2B ENSUMAP00000001239 ENSUMAP00000001239 IFT52 IFT52 VDR VDR PTPRK PTPRK AIMP1 AIMP1 TINF2 TINF2 DUSP10 DUSP10 MTSS1 MTSS1 BRCA2 BRCA2 TBC1D31 TBC1D31 IRF6 IRF6 APOH APOH IL26 IL26 TGFB2 TGFB2 CDC73 CDC73 SLURP1 SLURP1 STAT1 STAT1 PAX6 PAX6 STK4 STK4 SFRP1 SFRP1 EAF2 EAF2 DLG2 DLG2 INTU INTU CDK6 CDK6 KRIT1 KRIT1 SULF1 SULF1 GHRL GHRL HPN HPN RB1 RB1 NFIB NFIB MED1 MED1 MCC MCC FLT1 FLT1 ENSUMAP00000023341 ENSUMAP00000023341 STK3 STK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASKPeripheral plasma membrane protein CASK; Belongs to the MAGUK family. (843 aa)
ALOX5Arachidonate 5-lipoxygenase. (637 aa)
SFRP2Secreted frizzled-related protein 2. (299 aa)
TRIM24Transcription intermediary factor 1-alpha. (936 aa)
ZEB1Zinc finger E-box-binding homeobox 1. (1086 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GDF2Growth/differentiation factor 2. (402 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NF1Neurofibromin. (2862 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (339 aa)
PEX2Peroxisomal biogenesis factor 2. (305 aa)
CNMDLeukocyte cell-derived chemotaxin 1. (308 aa)
THBS1LOW QUALITY PROTEIN: thrombospondin-1. (1168 aa)
MMRN2Multimerin 2. (877 aa)
MUC16LOW QUALITY PROTEIN: mucin-16. (259 aa)
WDR77Methylosome protein 50. (342 aa)
MAGED1Melanoma-associated antigen D1 isoform X1. (821 aa)
TNMDTenomodulin. (343 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
CD109CD109 antigen. (1441 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (625 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (258 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (272 aa)
IFT80Intraflagellar transport protein 80 homolog isoform X1. (768 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (103 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
OVOL1Putative transcription factor Ovo-like 1. (114 aa)
PPARDLOW QUALITY PROTEIN: peroxisome proliferator-activated receptor delta. (397 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (176 aa)
PTCH1Protein patched homolog 1. (1388 aa)
SYNJ2BPSynaptojanin-2-binding protein. (145 aa)
LOC103675515Keratin, type II cytoskeletal 4; Belongs to the intermediate filament family. (532 aa)
SERPINF1Pigment epithelium-derived factor; Belongs to the serpin family. (418 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (339 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
VASH1Vasohibin-1. (363 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
SNAI2Zinc finger protein SNAI2. (263 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (340 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (457 aa)
IFT74Intraflagellar transport protein 74 homolog isoform X1. (600 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
CDKN2BAnkyrin repeat domain-containing protein 34A-like. (152 aa)
SAV1Salvador family WW domain containing protein 1. (351 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X3. (433 aa)
IFT57Intraflagellar transport protein 57 homolog. (390 aa)
GDF5LOW QUALITY PROTEIN: growth/differentiation factor 5. (306 aa)
FLCNFolliculin. (579 aa)
DAB2IPDisabled homolog 2-interacting protein. (877 aa)
PHB2Prohibitin. (297 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
PDCD10Programmed cell death protein 10. (212 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (185 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (106 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (187 aa)
ENSUMAP00000001239annotation not available (112 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (454 aa)
VDRVitamin D3 receptor isoform X2. (427 aa)
PTPRKReceptor-type tyrosine-protein phosphatase kappa. (1368 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (320 aa)
TINF2LOW QUALITY PROTEIN: TERF1-interacting nuclear factor 2. (394 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
MTSS1Metastasis suppressor protein 1. (782 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3418 aa)
TBC1D31TBC1 domain family member 31. (957 aa)
IRF6Interferon regulatory factor 6. (462 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
IL26Interleukin-26. (171 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
CDC73Parafibromin. (520 aa)
SLURP1Secreted LY6/PLAUR domain containing 1. (130 aa)
STAT1Signal transducer and activator of transcription. (809 aa)
PAX6Paired box protein Pax-6 isoform X2. (450 aa)
STK4Serine/threonine-protein kinase 4. (496 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
EAF2ELL-associated factor 2. (261 aa)
DLG2Disks large homolog 2 isoform X1. (843 aa)
INTUProtein inturned. (938 aa)
CDK6Cyclin-dependent kinase 6. (278 aa)
KRIT1Krev interaction trapped protein 1. (736 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (886 aa)
GHRLAppetite-regulating hormone isoform X1. (134 aa)
HPNSerine protease hepsin; Belongs to the peptidase S1 family. (237 aa)
RB1Retinoblastoma-associated protein. (920 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (559 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
MCCColorectal mutant cancer protein. (998 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (645 aa)
ENSUMAP00000023341annotation not available (433 aa)
STK3Serine/threonine-protein kinase 3. (497 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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