STRINGSTRING
SH3BP5L SH3BP5L FAM150A FAM150A IL31RA IL31RA IL6ST IL6ST CLEC6A CLEC6A PAK2 PAK2 INPP5F INPP5F SRC SRC FCGR1A FCGR1A CD74 CD74 FAM72A FAM72A PTPN6 PTPN6 HRG HRG ALKAL2 ALKAL2 IL2 IL2 IL21 IL21 CSF1R CSF1R AREG AREG EREG EREG EPGN EPGN ENSUMAP00000008777 ENSUMAP00000008777 ZFYVE28 ZFYVE28 CD81 CD81 DGKQ DGKQ NOD2 NOD2 VEGFA VEGFA FGF10 FGF10 CBLB CBLB KIT KIT BANK1 BANK1 AGT AGT ENSUMAP00000017050 ENSUMAP00000017050 SFRP1 SFRP1 FYN FYN PTPRC PTPRC CD80 CD80 HCLS1 HCLS1 PARP9 PARP9 VPS25 VPS25 IL11 IL11 LRRK1 LRRK1 PTPN1 PTPN1 ERRFI1 ERRFI1 NOX4 NOX4 GRM5 GRM5 IL22RA2 IL22RA2 CBL CBL ADRA2A ADRA2A MTOR MTOR CASS4 CASS4 TNFRSF18 TNFRSF18 KITLG KITLG CAV1 CAV1 CD3E CD3E ABI1 ABI1 ANGPT4 ANGPT4 HES1 HES1 AFAP1L2 AFAP1L2 HPX HPX PTK2B PTK2B CBLC CBLC SH2D1B SH2D1B LRP8 LRP8 MLST8 MLST8 GGNBP2 GGNBP2 SRMS SRMS PLPP3 PLPP3 ZGPAT ZGPAT ARL2BP ARL2BP TGFA TGFA GAS6 GAS6 ENPP2 ENPP2 IFNG IFNG CNOT7 CNOT7 TSG101 TSG101 HAX1 HAX1 IL6R IL6R TNFSF18 TNFSF18 RELN RELN ABL1 ABL1 GHRL GHRL ARHGEF2 ARHGEF2 CNTF CNTF BMP6 BMP6 IL5 IL5 IBTK IBTK EPHA4 EPHA4 NEDD9 NEDD9 CD44 CD44 SH3BP5 SH3BP5 IL34 IL34 PECAM1 PECAM1 HTR2A HTR2A IL23A IL23A LIF LIF OSM OSM SRCIN1-2 SRCIN1-2 SRCIN1 SRCIN1 TP53 TP53 NF2 NF2 ERBB3 ERBB3 PDGFC PDGFC SYK SYK SEMA4D SEMA4D SFRP2 SFRP2 SEMA4D-2 SEMA4D-2 FBXW7 FBXW7 NRP1 NRP1 ITGB3 ITGB3 SOCS4 SOCS4 GREM1 GREM1 ERCC6 ERCC6 TMEM102 TMEM102 HBEGF HBEGF RIPK2 RIPK2 BTC BTC CSF2 CSF2 DMTN DMTN FBXW9 FBXW9 SH2B3 SH2B3 TNFRSF1A TNFRSF1A PTPN2 PTPN2 GATA1 GATA1 NTF3 NTF3 PDCL3 PDCL3 RICTOR RICTOR CD300A CD300A PDGFD PDGFD EGFR EGFR CHMP6 CHMP6 PLCG2 PLCG2 IL15 IL15 DVL2 DVL2 NCF1 NCF1 EFNA5 EFNA5 IL7 IL7 APP APP FGF7 FGF7 SAMSN1 SAMSN1 PDGFB PDGFB LRP4 LRP4 HGF HGF CTF1 CTF1 NCAPG2 NCAPG2 STAP1 STAP1 PRKCE PRKCE ENSUMAP00000017592 ENSUMAP00000017592 CLCF1 CLCF1 ZZEF1 ZZEF1 TREML1 TREML1 TREM2 TREM2 VTN VTN UNC119 UNC119 THBS4 THBS4 ITGA5 ITGA5 MVP MVP LOC103672907 LOC103672907 TNFRSF14 TNFRSF14 PRKCZ PRKCZ PIBF1 PIBF1 SPINK1 SPINK1 PTPN11 PTPN11 LYN LYN RACK1 RACK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SH3BP5LSH3 binding domain protein 5 like. (385 aa)
FAM150AProtein FAM150A. (58 aa)
IL31RAInterleukin-31 receptor subunit alpha. (730 aa)
IL6STInterleukin-6 receptor subunit beta isoform X1. (918 aa)
CLEC6ALOW QUALITY PROTEIN: C-type lectin domain family 6 member A. (231 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
INPP5FPhosphatidylinositide phosphatase SAC2 isoform X1. (1131 aa)
SRCTyrosine-protein kinase. (618 aa)
FCGR1ALOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I. (492 aa)
CD74LOW QUALITY PROTEIN: HLA class II histocompatibility antigen gamma chain. (279 aa)
FAM72AProtein FAM72A. (149 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
HRGHistidine-rich glycoprotein. (521 aa)
ALKAL2Protein FAM150B. (126 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
AREGAmphiregulin. (253 aa)
EREGProepiregulin. (175 aa)
EPGNEpithelial mitogen. (138 aa)
ENSUMAP00000008777annotation not available (79 aa)
ZFYVE28Lateral signaling target protein 2 homolog. (791 aa)
CD81Tetraspanin. (429 aa)
DGKQDiacylglycerol kinase. (886 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (817 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (179 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (983 aa)
KITMast/stem cell growth factor receptor Kit; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
BANK1B-cell scaffold protein with ankyrin repeats. (753 aa)
AGTAngiotensinogen; Belongs to the serpin family. (475 aa)
ENSUMAP00000017050annotation not available (80 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
FYNTyrosine-protein kinase. (576 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1268 aa)
CD80T-lymphocyte activation antigen CD80. (302 aa)
HCLS1Hematopoietic lineage cell-specific protein. (510 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (827 aa)
VPS25Vacuolar protein-sorting-associated protein 25. (192 aa)
IL11LOW QUALITY PROTEIN: interleukin-11. (199 aa)
LRRK1LOW QUALITY PROTEIN: leucine-rich repeat serine/threonine-protein kinase 1. (1980 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (424 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (98 aa)
NOX4NADPH oxidase 4. (578 aa)
GRM5Glutamate metabotropic receptor 5. (959 aa)
IL22RA2Interleukin-22 receptor subunit alpha-2. (231 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X2. (910 aa)
ADRA2AAdrenoceptor alpha 2A. (418 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2531 aa)
CASS4Cas scaffolding protein family member 4. (806 aa)
TNFRSF18Tumor necrosis factor receptor superfamily member 18. (238 aa)
KITLGKit ligand. (274 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (201 aa)
ABI1Abl interactor 1 isoform X3. (468 aa)
ANGPT4Angiopoietin 4. (463 aa)
HES1Transcription factor HES-1. (166 aa)
AFAP1L2Actin filament-associated protein 1-like 2. (763 aa)
HPXHemopexin. (396 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CBLCE3 ubiquitin-protein ligase CBL-C. (437 aa)
SH2D1BSH2 domain-containing protein 1B. (143 aa)
LRP8LDL receptor related protein 8. (925 aa)
MLST8Target of rapamycin complex subunit LST8. (451 aa)
GGNBP2Gametogenetin-binding protein 2. (665 aa)
SRMSTyrosine-protein kinase. (581 aa)
PLPP3Lipid phosphate phosphohydrolase 3. (273 aa)
ZGPATZinc finger CCCH-type with G patch domain-containing protein. (508 aa)
ARL2BPADP-ribosylation factor-like protein 2-binding protein isoform X1. (175 aa)
TGFAProtransforming growth factor alpha. (92 aa)
GAS6LOW QUALITY PROTEIN: growth arrest-specific protein 6. (614 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1. (940 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
TSG101Tumor susceptibility gene 101 protein. (417 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (238 aa)
IL6RLOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha. (458 aa)
TNFSF18Tumor necrosis factor ligand superfamily member 18. (178 aa)
RELNLOW QUALITY PROTEIN: reelin. (3457 aa)
ABL1Tyrosine-protein kinase. (1135 aa)
GHRLAppetite-regulating hormone isoform X1. (134 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2. (725 aa)
CNTFCiliary neurotrophic factor. (200 aa)
BMP6Bone morphogenetic protein 6. (364 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (131 aa)
IBTKInhibitor of Bruton Tyrosine kinase. (1354 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (911 aa)
NEDD9Enhancer of filamentation 1. (842 aa)
CD44CD44 antigen isoform X7. (581 aa)
SH3BP5SH3 domain-binding protein 5. (428 aa)
IL34Interleukin-34 isoform X1. (236 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X1. (765 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
IL23AInterleukin-23 subunit alpha. (190 aa)
LIFLeukemia inhibitory factor. (204 aa)
OSMoncostatin-M isoform X1. (238 aa)
SRCIN1-2SRC kinase signaling inhibitor 1. (497 aa)
SRCIN1SRC kinase signaling inhibitor 1. (985 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
NF2LOW QUALITY PROTEIN: merlin. (595 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1342 aa)
PDGFCPlatelet-derived growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
SYKTyrosine-protein kinase SYK; Belongs to the protein kinase superfamily. Tyr protein kinase family. (610 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (777 aa)
SFRP2Secreted frizzled-related protein 2. (299 aa)
SEMA4D-2Semaphorin 4D. (117 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (706 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (783 aa)
SOCS4Suppressor of cytokine signaling 4. (439 aa)
GREM1Gremlin. (232 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1482 aa)
TMEM102Transmembrane protein 102. (320 aa)
HBEGFProheparin-binding EGF-like growth factor. (201 aa)
RIPK2LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2. (512 aa)
BTCProbetacellulin. (180 aa)
CSF2Granulocyte-macrophage colony-stimulating factor isoform X1. (277 aa)
DMTNDematin. (371 aa)
FBXW9F-box/WD repeat-containing protein 9. (367 aa)
SH2B3SH2B adapter protein 3. (368 aa)
TNFRSF1ALOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A. (507 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (400 aa)
GATA1LOW QUALITY PROTEIN: erythroid transcription factor. (438 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
PDCL3Phosducin-like protein 3. (240 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X3. (1684 aa)
CD300ACMRF35-like molecule 8. (168 aa)
PDGFDPlatelet-derived growth factor D. (365 aa)
EGFRReceptor protein-tyrosine kinase. (1191 aa)
CHMP6Charged multivesicular body protein 6. (191 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1191 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (391 aa)
NCF1Neutrophil cytosol factor 1. (389 aa)
EFNA5ephrin-A5; Belongs to the ephrin family. (188 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (747 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SAMSN1SAM domain, SH3 domain and nuclear localization signals 1. (635 aa)
PDGFBPlatelet-derived growth factor subunit B. (234 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1742 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
CTF1Cardiotrophin-1. (184 aa)
NCAPG2Condensin-2 complex subunit G2 isoform X1. (1138 aa)
STAP1Signal-transducing adaptor protein 1 isoform X1. (293 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (226 aa)
ENSUMAP00000017592annotation not available (120 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (215 aa)
ZZEF1LOW QUALITY PROTEIN: zinc finger ZZ-type and EF-hand domain-containing protein 1. (2732 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (313 aa)
TREM2Triggering receptor expressed on myeloid cells 2 isoform X2. (322 aa)
VTNVitronectin. (470 aa)
UNC119Unc-119 lipid binding chaperone. (174 aa)
THBS4Thrombospondin-4. (981 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1015 aa)
MVPLOW QUALITY PROTEIN: major vault protein. (199 aa)
LOC103672907Leukocyte immunoglobulin-like receptor subfamily A member 6. (297 aa)
TNFRSF14Tumor necrosis factor receptor superfamily member 14 isoform X1. (350 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
PIBF1Progesterone-induced-blocking factor 1 isoform X1. (757 aa)
SPINK1Pancreatic secretory trypsin inhibitor. (58 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
LYNTyrosine-protein kinase. (512 aa)
RACK1Guanine nucleotide-binding protein subunit beta-2-like 1. (374 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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