STRINGSTRING
HES1 HES1 WNT3A WNT3A MT3 MT3 TLX2 TLX2 SEMA4F SEMA4F ULK1 ULK1 SEMA6C SEMA6C LHX2 LHX2 BRINP1 BRINP1 GPR37L1 GPR37L1 DNAJB11 DNAJB11 GORASP1 GORASP1 SEMA7A SEMA7A PPP3CA PPP3CA B2M B2M SEMA6B SEMA6B SEMA4B SEMA4B REST REST DIP2B DIP2B PTPRS PTPRS SEMA6D SEMA6D SEMA4C SEMA4C TREM2 TREM2 TREML1 TREML1 SYNGAP1 SYNGAP1 PTEN PTEN SEMA3C SEMA3C BMPR1A BMPR1A LRP4 LRP4 F2 F2 DLX1 DLX1 NF1 NF1 RYK RYK WNT3 WNT3 TMEM98 TMEM98 YWHAH YWHAH PTN PTN SEMA4D-2 SEMA4D-2 SEMA4D SEMA4D CDK5 CDK5 SEMA3E SEMA3E NF2 NF2 RTN4 RTN4 TP53 TP53 EFNB3 EFNB3 SEMA3A SEMA3A SEMA3D SEMA3D APPL2 APPL2 KIFAP3 KIFAP3 NR1D1 NR1D1 CDKL3 CDKL3 FSTL4 FSTL4 PROX1 PROX1 RB1 RB1 SEMA4A SEMA4A SEMA6A SEMA6A GDI1 GDI1 PAX6 PAX6 CTDSP1 CTDSP1 RAPGEF2 RAPGEF2 NR2E1 NR2E1 TNR TNR PCM1 PCM1 SEMA3G SEMA3G LDLR LDLR IFRD2 IFRD2 SEMA3B SEMA3B SEMA3F SEMA3F DPYSL5 DPYSL5 SEMA5A SEMA5A SORL1 SORL1 DRAXIN DRAXIN NFATC4 NFATC4 SEMA4G SEMA4G PRTG PRTG THY1 THY1 SPART SPART HOOK3 HOOK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HES1Transcription factor HES-1. (166 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
MT3Metallothionein 3. (68 aa)
TLX2T-cell leukemia homeobox protein 2. (284 aa)
SEMA4Fsemaphorin-4F isoform X1; Belongs to the semaphorin family. (767 aa)
ULK1Serine/threonine-protein kinase ULK1. (835 aa)
SEMA6Csemaphorin-6C; Belongs to the semaphorin family. (804 aa)
LHX2LIM/homeobox protein Lhx2. (331 aa)
BRINP1BMP/retinoic acid-inducible neural-specific protein 1. (761 aa)
GPR37L1G protein-coupled receptor 37 like 1. (476 aa)
DNAJB11dnaJ homolog subfamily B member 11 isoform X2. (386 aa)
GORASP1Golgi reassembly-stacking protein 1 isoform X1. (508 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (662 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (648 aa)
SEMA4BLOW QUALITY PROTEIN: semaphorin-4B; Belongs to the semaphorin family. (847 aa)
RESTRE1-silencing transcription factor. (1213 aa)
DIP2BDisco-interacting protein 2 homolog B. (1459 aa)
PTPRSReceptor-type tyrosine-protein phosphatase S. (1655 aa)
SEMA6Dsemaphorin-6D isoform X1; Belongs to the semaphorin family. (1086 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (843 aa)
TREM2Triggering receptor expressed on myeloid cells 2 isoform X2. (322 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (313 aa)
SYNGAP1LOW QUALITY PROTEIN: ras/Rap GTPase-activating protein SynGAP. (1229 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
SEMA3CSemaphorin-3C; Belongs to the semaphorin family. (750 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1742 aa)
F2Prothrombin; Belongs to the peptidase S1 family. (569 aa)
DLX1LOW QUALITY PROTEIN: homeobox protein DLX-1. (243 aa)
NF1Neurofibromin. (2862 aa)
RYKTyrosine-protein kinase RYK. (572 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (175 aa)
TMEM98LOW QUALITY PROTEIN: transmembrane protein 98. (304 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (240 aa)
PTNPleiotrophin. (210 aa)
SEMA4D-2Semaphorin 4D. (117 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (777 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (361 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (781 aa)
NF2LOW QUALITY PROTEIN: merlin. (595 aa)
RTN4Reticulon. (978 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
EFNB3ephrin-B3; Belongs to the ephrin family. (326 aa)
SEMA3ASemaphorin-3A; Belongs to the semaphorin family. (772 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (743 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (619 aa)
KIFAP3Kinesin-associated protein 3. (793 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
CDKL3Cyclin-dependent kinase-like 3 isoform X2. (603 aa)
FSTL4Follistatin-related protein 4. (682 aa)
PROX1Prospero homeobox protein 1. (737 aa)
RB1Retinoblastoma-associated protein. (920 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (778 aa)
SEMA6ALOW QUALITY PROTEIN: semaphorin-6A; Belongs to the semaphorin family. (1028 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (443 aa)
PAX6Paired box protein Pax-6 isoform X2. (450 aa)
CTDSP1Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1. (336 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2 isoform X2. (1678 aa)
NR2E1LOW QUALITY PROTEIN: nuclear receptor subfamily 2 group E member 1. (372 aa)
TNRtenascin-R. (1349 aa)
PCM1Pericentriolar material 1 protein. (2187 aa)
SEMA3Gsemaphorin-3G; Belongs to the semaphorin family. (748 aa)
LDLRLow-density lipoprotein receptor. (927 aa)
IFRD2Interferon-related developmental regulator 2. (561 aa)
SEMA3Bsemaphorin-3B; Belongs to the semaphorin family. (677 aa)
SEMA3Fsemaphorin-3F; Belongs to the semaphorin family. (578 aa)
DPYSL5Dihydropyrimidinase-related protein 5. (564 aa)
SEMA5ALOW QUALITY PROTEIN: semaphorin-5A. (1055 aa)
SORL1Sortilin-related receptor. (2185 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (347 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (787 aa)
SEMA4GLOW QUALITY PROTEIN: semaphorin-4G; Belongs to the semaphorin family. (464 aa)
PRTGProtogenin. (1194 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
SPARTSpartin isoform X2. (672 aa)
HOOK3Protein Hook homolog 3. (678 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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