STRINGSTRING
EFNA5 EFNA5 SS18L1 SS18L1 BHLHB9 BHLHB9 HES1 HES1 WNT3A WNT3A CAPRIN2 CAPRIN2 LPAR3 LPAR3 WNT2 WNT2 SHTN1 SHTN1 PLXNC1 PLXNC1 KRAS KRAS TGM2 TGM2 CTNNB1 CTNNB1 TRIM32 TRIM32 FGF2 FGF2 NEFL NEFL CX3CR1 CX3CR1 MAP3K13 MAP3K13 SEMA7A SEMA7A BMP2 BMP2 ISLR2 ISLR2 NPTN NPTN NIN NIN FOXG1 FOXG1 LOC103677394 LOC103677394 STK11 STK11 RNF112 RNF112 GOLGA4 GOLGA4 GPER1 GPER1 DISC1 DISC1 EGR2 EGR2 TRPV2 TRPV2 SMO SMO SNW1 SNW1 LAYN LAYN CUX2 CUX2 ASPA ASPA ELL3 ELL3 BIN1 BIN1 SRF SRF CUL7 CUL7 CUL7-2 CUL7-2 CDKL5 CDKL5 NUMB NUMB OCM2 OCM2 IL6ST IL6ST PAFAH1B1 PAFAH1B1 SERPINF1 SERPINF1 PLAG1 PLAG1 DBNL DBNL GLI3 GLI3 STK25 STK25 FBXW8 FBXW8 SRRT SRRT PRKCI PRKCI NGF NGF TENM4 TENM4 DHX36 DHX36 KHDC3L KHDC3L CLCF1 CLCF1 KDM1A KDM1A TIAM2 TIAM2 OPRM1 OPRM1 HIF1A HIF1A ENSUMAP00000018664 ENSUMAP00000018664 PRKCH PRKCH LRP2 LRP2 LIMK1 LIMK1 ANKRD27 ANKRD27 GFAP GFAP PLXNA1 PLXNA1 CHODL CHODL SLITRK1 SLITRK1 FAIM FAIM BRAF BRAF SOX10 SOX10 TNF TNF MAN2A1 MAN2A1 ZNF488 ZNF488 WNT3 WNT3 XRCC2 XRCC2 ITGB1 ITGB1 PTN PTN SMARCD3 SMARCD3 SEMA4D-2 SEMA4D-2 SEMA4D SEMA4D LIF LIF PLXNA4 PLXNA4 PLXND1 PLXND1 JADE2 JADE2 CDKL3 CDKL3 IL34 IL34 METRNL METRNL SERPINE2 SERPINE2 IST1 IST1 OBSL1 OBSL1 PLXNB2 PLXNB2 CAPRIN1 CAPRIN1 RELN RELN PAX6 PAX6 NR2E1 NR2E1 NUMB-2 NUMB-2 XRCC5 XRCC5 PKHD1L1 PKHD1L1 IFNG IFNG MECP2 MECP2 SOX8 SOX8 TWF2 TWF2 UFL1 UFL1 SPEN SPEN BMPR2 BMPR2 TNFRSF1B TNFRSF1B PLXNA2 PLXNA2 LRP8 LRP8 FZD3 FZD3 ZFYVE27 ZFYVE27 MTOR MTOR VEGFC VEGFC DBN1 DBN1 ZNF335 ZNF335 ENSUMAP00000035037 ENSUMAP00000035037 DCT DCT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFNA5ephrin-A5; Belongs to the ephrin family. (188 aa)
SS18L1Calcium-responsive transactivator. (423 aa)
BHLHB9Protein BHLHb9. (550 aa)
HES1Transcription factor HES-1. (166 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CAPRIN2Caprin family member 2. (1067 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
SHTN1Shootin-1. (623 aa)
PLXNC1plexin-C1. (1355 aa)
KRASGTPase KRas isoform X3. (189 aa)
TGM2Protein-glutamine gamma-glutamyltransferase 2. (687 aa)
CTNNB1Catenin beta-1. (787 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32. (654 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
NEFLNeurofilament light polypeptide; Belongs to the intermediate filament family. (516 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (944 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (662 aa)
BMP2Bone morphogenetic protein 2 isoform X2. (395 aa)
ISLR2LOW QUALITY PROTEIN: immunoglobulin superfamily containing leucine-rich repeat protein 2. (448 aa)
NPTNNeuroplastin. (367 aa)
NINLOW QUALITY PROTEIN: ninein. (1951 aa)
FOXG1Forkhead box protein G1. (221 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (457 aa)
RNF112RING finger protein 112. (425 aa)
GOLGA4LOW QUALITY PROTEIN: golgin subfamily A member 4. (2262 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
DISC1LOW QUALITY PROTEIN: disrupted in schizophrenia 1 protein. (861 aa)
EGR2LOW QUALITY PROTEIN: E3 SUMO-protein ligase EGR2. (323 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (797 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (745 aa)
SNW1SNW domain-containing protein 1. (536 aa)
LAYNLayilin. (355 aa)
CUX2Homeobox protein cut-like. (1499 aa)
ASPAAspartoacylase. (313 aa)
ELL3RNA polymerase II elongation factor ELL3. (324 aa)
BIN1Myc box-dependent-interacting protein 1 isoform X14. (523 aa)
SRFSerum response factor. (446 aa)
CUL7LOW QUALITY PROTEIN: cullin-7; Belongs to the cullin family. (613 aa)
CUL7-2Cullin 7. (229 aa)
CDKL5Cyclin-dependent kinase-like 5. (932 aa)
NUMBProtein numb homolog isoform X3. (673 aa)
OCM2Putative oncomodulin-2; Belongs to the parvalbumin family. (109 aa)
IL6STInterleukin-6 receptor subunit beta isoform X1. (918 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
SERPINF1Pigment epithelium-derived factor; Belongs to the serpin family. (418 aa)
PLAG1Zinc finger protein PLAG1 isoform X1. (499 aa)
DBNLLOW QUALITY PROTEIN: drebrin-like protein. (139 aa)
GLI3Transcriptional activator GLI3. (524 aa)
STK25Serine/threonine-protein kinase 25. (422 aa)
FBXW8F-box/WD repeat-containing protein 8. (553 aa)
SRRTSerrate RNA effector molecule homolog isoform X1. (876 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (569 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (356 aa)
TENM4Teneurin-4-like. (2643 aa)
DHX36ATP-dependent RNA helicase DHX36. (1011 aa)
KHDC3LKHDC3-like protein. (218 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (215 aa)
KDM1ALysine-specific histone demethylase 1A isoform X2. (671 aa)
TIAM2T-lymphoma invasion and metastasis-inducing protein 2. (617 aa)
OPRM1LOW QUALITY PROTEIN: mu-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (468 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
ENSUMAP00000018664annotation not available (401 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (403 aa)
LIMK1LIM domain kinase 1. (653 aa)
ANKRD27LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 27. (1046 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (515 aa)
PLXNA1LOW QUALITY PROTEIN: plexin-A1. (1729 aa)
CHODLChondrolectin isoform X1. (273 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
FAIMFas apoptotic inhibitory molecule 1. (201 aa)
BRAFSerine/threonine-protein kinase B-raf. (715 aa)
SOX10Transcription factor SOX-10. (305 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAN2A1Alpha-mannosidase. (1148 aa)
ZNF488Zinc finger protein 488. (324 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (175 aa)
XRCC2X-ray repair cross complementing 2. (279 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PTNPleiotrophin. (210 aa)
SMARCD3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (502 aa)
SEMA4D-2Semaphorin 4D. (117 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (777 aa)
LIFLeukemia inhibitory factor. (204 aa)
PLXNA4plexin-A4 isoform X1. (1884 aa)
PLXND1LOW QUALITY PROTEIN: plexin-D1. (1503 aa)
JADE2LOW QUALITY PROTEIN: protein Jade-2. (805 aa)
CDKL3Cyclin-dependent kinase-like 3 isoform X2. (603 aa)
IL34Interleukin-34 isoform X1. (236 aa)
METRNLMeteorin-like protein. (358 aa)
SERPINE2Glia-derived nexin; Belongs to the serpin family. (397 aa)
IST1IST1 factor associated with ESCRT-III. (366 aa)
OBSL1Obscurin-like protein 1. (1222 aa)
PLXNB2LOW QUALITY PROTEIN: plexin-B2. (1590 aa)
CAPRIN1Caprin-1. (660 aa)
RELNLOW QUALITY PROTEIN: reelin. (3457 aa)
PAX6Paired box protein Pax-6 isoform X2. (450 aa)
NR2E1LOW QUALITY PROTEIN: nuclear receptor subfamily 2 group E member 1. (372 aa)
NUMB-2Protein numb homolog isoform X7. (70 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa)
PKHD1L1fibrocystin-L. (4236 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
MECP2methyl-CpG-binding protein 2. (172 aa)
SOX8Transcription factor SOX-8. (216 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
UFL1E3 UFM1-protein ligase 1. (792 aa)
SPENLOW QUALITY PROTEIN: msx2-interacting protein. (3648 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TNFRSF1BLOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1B. (313 aa)
PLXNA2LOW QUALITY PROTEIN: plexin-A2. (1891 aa)
LRP8LDL receptor related protein 8. (925 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (404 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2531 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (436 aa)
DBN1LOW QUALITY PROTEIN: drebrin. (966 aa)
ZNF335Zinc finger protein 335. (1320 aa)
ENSUMAP00000035037annotation not available (85 aa)
DCTL-dopachrome tautomerase. (516 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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