STRINGSTRING
SPART SPART CDH4 CDH4 WNT3A WNT3A MT3 MT3 SEMA4F SEMA4F LPAR3 LPAR3 UST UST ULK1 ULK1 SEMA6C SEMA6C SHTN1 SHTN1 PAK2 PAK2 PLXNC1 PLXNC1 CNTN2 CNTN2 RUFY3 RUFY3 NEFL NEFL MAP3K13 MAP3K13 SEMA7A SEMA7A EPHB3 EPHB3 ISLR2 ISLR2 NIN NIN STK11 STK11 GOLGA4 GOLGA4 TRPV2 TRPV2 LAYN LAYN SEMA6B SEMA6B SEMA4B SEMA4B DIP2B DIP2B SRF SRF CDKL5 CDKL5 OCM2 OCM2 SIPA1L1 SIPA1L1 PTPRS PTPRS SEMA6D SEMA6D DBNL DBNL ENSUMAP00000035037 ENSUMAP00000035037 STK25 STK25 PAK1 PAK1 NGF NGF SEMA4C SEMA4C KEL KEL SYNGAP1 SYNGAP1 PTEN PTEN TIAM2 TIAM2 SEMA3C SEMA3C LIMK1 LIMK1 LRP4 LRP4 PLXNA1 PLXNA1 CHODL CHODL SLITRK1 SLITRK1 EFNA5 EFNA5 BRAF BRAF RYK RYK WNT3 WNT3 SEMA4D-2 SEMA4D-2 SEMA4D SEMA4D RET RET CDK5 CDK5 SEMA3E SEMA3E RTN4 RTN4 EFNB3 EFNB3 SEMA3A SEMA3A SEMA3D SEMA3D PLXNA4 PLXNA4 PLXND1 PLXND1 CDKL3 CDKL3 METRNL METRNL FSTL4 FSTL4 IST1 IST1 EPHA4 EPHA4 SEMA4A SEMA4A PLXNB2 PLXNB2 SEMA6A SEMA6A GDI1 GDI1 PKHD1L1 PKHD1L1 TNR TNR SEMA3G SEMA3G TWF2 TWF2 CDH2 CDH2 BMPR2 BMPR2 IFRD2 IFRD2 SEMA3B SEMA3B SEMA3F SEMA3F PLXNA2 PLXNA2 SEMA5A SEMA5A ZFYVE27 ZFYVE27 DRAXIN DRAXIN SEMA4G SEMA4G PAK3 PAK3 THY1 THY1 ARHGAP35 ARHGAP35
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPARTSpartin isoform X2. (672 aa)
CDH4Cadherin-4; Cadherins are calcium-dependent cell adhesion proteins. (868 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
MT3Metallothionein 3. (68 aa)
SEMA4Fsemaphorin-4F isoform X1; Belongs to the semaphorin family. (767 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
USTUronyl 2-sulfotransferase. (378 aa)
ULK1Serine/threonine-protein kinase ULK1. (835 aa)
SEMA6Csemaphorin-6C; Belongs to the semaphorin family. (804 aa)
SHTN1Shootin-1. (623 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PLXNC1plexin-C1. (1355 aa)
CNTN2Contactin-2. (1008 aa)
RUFY3RUN and FYVE domain containing 3. (620 aa)
NEFLNeurofilament light polypeptide; Belongs to the intermediate filament family. (516 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (944 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (662 aa)
EPHB3Ephrin type-B receptor 3. (930 aa)
ISLR2LOW QUALITY PROTEIN: immunoglobulin superfamily containing leucine-rich repeat protein 2. (448 aa)
NINLOW QUALITY PROTEIN: ninein. (1951 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (457 aa)
GOLGA4LOW QUALITY PROTEIN: golgin subfamily A member 4. (2262 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (797 aa)
LAYNLayilin. (355 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (648 aa)
SEMA4BLOW QUALITY PROTEIN: semaphorin-4B; Belongs to the semaphorin family. (847 aa)
DIP2BDisco-interacting protein 2 homolog B. (1459 aa)
SRFSerum response factor. (446 aa)
CDKL5Cyclin-dependent kinase-like 5. (932 aa)
OCM2Putative oncomodulin-2; Belongs to the parvalbumin family. (109 aa)
SIPA1L1Signal-induced proliferation-associated 1-like protein 1 isoform X1. (1785 aa)
PTPRSReceptor-type tyrosine-protein phosphatase S. (1655 aa)
SEMA6Dsemaphorin-6D isoform X1; Belongs to the semaphorin family. (1086 aa)
DBNLLOW QUALITY PROTEIN: drebrin-like protein. (139 aa)
ENSUMAP00000035037annotation not available (85 aa)
STK25Serine/threonine-protein kinase 25. (422 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (356 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (843 aa)
KELKell blood group glycoprotein isoform X1. (752 aa)
SYNGAP1LOW QUALITY PROTEIN: ras/Rap GTPase-activating protein SynGAP. (1229 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
TIAM2T-lymphoma invasion and metastasis-inducing protein 2. (617 aa)
SEMA3CSemaphorin-3C; Belongs to the semaphorin family. (750 aa)
LIMK1LIM domain kinase 1. (653 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1742 aa)
PLXNA1LOW QUALITY PROTEIN: plexin-A1. (1729 aa)
CHODLChondrolectin isoform X1. (273 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
EFNA5ephrin-A5; Belongs to the ephrin family. (188 aa)
BRAFSerine/threonine-protein kinase B-raf. (715 aa)
RYKTyrosine-protein kinase RYK. (572 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (175 aa)
SEMA4D-2Semaphorin 4D. (117 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (777 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1131 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (361 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (781 aa)
RTN4Reticulon. (978 aa)
EFNB3ephrin-B3; Belongs to the ephrin family. (326 aa)
SEMA3ASemaphorin-3A; Belongs to the semaphorin family. (772 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (743 aa)
PLXNA4plexin-A4 isoform X1. (1884 aa)
PLXND1LOW QUALITY PROTEIN: plexin-D1. (1503 aa)
CDKL3Cyclin-dependent kinase-like 3 isoform X2. (603 aa)
METRNLMeteorin-like protein. (358 aa)
FSTL4Follistatin-related protein 4. (682 aa)
IST1IST1 factor associated with ESCRT-III. (366 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (911 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (778 aa)
PLXNB2LOW QUALITY PROTEIN: plexin-B2. (1590 aa)
SEMA6ALOW QUALITY PROTEIN: semaphorin-6A; Belongs to the semaphorin family. (1028 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (443 aa)
PKHD1L1fibrocystin-L. (4236 aa)
TNRtenascin-R. (1349 aa)
SEMA3Gsemaphorin-3G; Belongs to the semaphorin family. (748 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
CDH2Cadherin-2; Cadherins are calcium-dependent cell adhesion proteins. (904 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
IFRD2Interferon-related developmental regulator 2. (561 aa)
SEMA3Bsemaphorin-3B; Belongs to the semaphorin family. (677 aa)
SEMA3Fsemaphorin-3F; Belongs to the semaphorin family. (578 aa)
PLXNA2LOW QUALITY PROTEIN: plexin-A2. (1891 aa)
SEMA5ALOW QUALITY PROTEIN: semaphorin-5A. (1055 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (404 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (347 aa)
SEMA4GLOW QUALITY PROTEIN: semaphorin-4G; Belongs to the semaphorin family. (464 aa)
PAK3Non-specific serine/threonine protein kinase. (554 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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