(47 nodes) Extracellular matrix binding network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ELN	Elastin. (503 aa)
	ITGA2B	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1086 aa)
	VTN	Vitronectin. (470 aa)
	CD248	Endosialin. (443 aa)
	GPC1	Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (531 aa)
	SMOC1	SPARC-related modular calcium-binding protein 1. (466 aa)
	ZAN	LOW QUALITY PROTEIN: zonadhesin. (2464 aa)
	NID1	Nidogen-1. (1172 aa)
	LRRC15	Leucine-rich repeat-containing protein 15. (413 aa)
	CCN1	Cellular communication network factor 1. (382 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (355 aa)
	AGRN	Agrin. (1680 aa)
	OLFML2A	Olfactomedin-like protein 2A. (659 aa)
	SPARC	Secreted protein acidic and cysteine rich. (330 aa)
	SLIT2	Slit homolog 2 protein isoform X1. (1530 aa)
	NTN4	Netrin-4 isoform X1. (591 aa)
	ECM1	LOW QUALITY PROTEIN: extracellular matrix protein 1. (473 aa)
	PXDN	Peroxidasin homolog. (1405 aa)
	RPSA	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (323 aa)
	ENSUMAP00000007108	annotation not available (349 aa)
	GPR126	G-protein coupled receptor 126; Belongs to the G-protein coupled receptor 2 family. (543 aa)
	ADAMTS15	A disintegrin and metalloproteinase with thrombospondin motifs 15. (894 aa)
	PXDNL	Peroxidasin-like protein. (1278 aa)
	CLEC14A	C-type lectin domain family 14 member A. (495 aa)
	SPOCK2	LOW QUALITY PROTEIN: testican-2. (370 aa)
	SMOC2	SPARC-related modular calcium-binding protein 2. (423 aa)
	TINAGL1	Tubulointerstitial nephritis antigen like 1; Belongs to the peptidase C1 family. (424 aa)
	ADAM9	Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (819 aa)
	DMP1	Dentin matrix acidic phosphoprotein 1 isoform X2. (502 aa)
	SPARCL1	SPARC-like protein 1 isoform X2. (633 aa)
	SSC5D	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D. (1449 aa)
	BCAM	Basal cell adhesion molecule. (705 aa)
	LYPD3	ly6/PLAUR domain-containing protein 3. (347 aa)
	DAG1	Dystroglycan 1. (888 aa)
	OLFML2B	Olfactomedin-like protein 2B. (721 aa)
	ADGRG1	LOW QUALITY PROTEIN: G-protein coupled receptor 56; Belongs to the G-protein coupled receptor 2 family. (660 aa)
	BGN	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (369 aa)
	C6orf15	Uncharacterized protein C6orf15 homolog. (305 aa)
	FCGBP	LOW QUALITY PROTEIN: IgGFc-binding protein. (2327 aa)
	ITGAV	LOW QUALITY PROTEIN: integrin alpha-V; Belongs to the integrin alpha chain family. (1056 aa)
	TGFBI	Transforming growth factor-beta-induced protein ig-h3. (650 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (783 aa)
	LGALS3	Galectin. (282 aa)
	FBLN2	Fibulin-2. (1112 aa)
	ADAMTS5	A disintegrin and metalloproteinase with thrombospondin motifs 5. (809 aa)
	THBS1	LOW QUALITY PROTEIN: thrombospondin-1. (1168 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS5	BGN	ENSUMAP00000020304	ENSUMAP00000029299	A disintegrin and metalloproteinase with thrombospondin motifs 5.	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.440
AGRN	BGN	ENSUMAP00000003074	ENSUMAP00000029299	Agrin.	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.730
AGRN	DAG1	ENSUMAP00000003074	ENSUMAP00000031621	Agrin.	Dystroglycan 1.	0.994
AGRN	DCN	ENSUMAP00000003074	ENSUMAP00000002856	Agrin.	Decorin; May affect the rate of fibrils formation.	0.635
AGRN	GPC1	ENSUMAP00000003074	ENSUMAP00000014832	Agrin.	Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.576
AGRN	ITGB1	ENSUMAP00000003074	ENSUMAP00000021969	Agrin.	Integrin beta; Belongs to the integrin beta chain family.	0.595
AGRN	NID1	ENSUMAP00000003074	ENSUMAP00000012999	Agrin.	Nidogen-1.	0.799
AGRN	SPARC	ENSUMAP00000003074	ENSUMAP00000004061	Agrin.	Secreted protein acidic and cysteine rich.	0.494
AGRN	VTN	ENSUMAP00000003074	ENSUMAP00000016414	Agrin.	Vitronectin.	0.494
BGN	ADAMTS5	ENSUMAP00000029299	ENSUMAP00000020304	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	A disintegrin and metalloproteinase with thrombospondin motifs 5.	0.440
BGN	AGRN	ENSUMAP00000029299	ENSUMAP00000003074	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Agrin.	0.730
BGN	CD248	ENSUMAP00000029299	ENSUMAP00000015213	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Endosialin.	0.417
BGN	DAG1	ENSUMAP00000029299	ENSUMAP00000031621	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Dystroglycan 1.	0.457
BGN	DCN	ENSUMAP00000029299	ENSUMAP00000002856	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Decorin; May affect the rate of fibrils formation.	0.851
BGN	ELN	ENSUMAP00000029299	ENSUMAP00000019058	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Elastin.	0.681
BGN	FBLN2	ENSUMAP00000029299	ENSUMAP00000021697	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Fibulin-2.	0.480
BGN	GPC1	ENSUMAP00000029299	ENSUMAP00000014832	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.646
BGN	SPARC	ENSUMAP00000029299	ENSUMAP00000004061	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Secreted protein acidic and cysteine rich.	0.639
BGN	THBS1	ENSUMAP00000029299	ENSUMAP00000019620	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	LOW QUALITY PROTEIN: thrombospondin-1.	0.510
BGN	VTN	ENSUMAP00000029299	ENSUMAP00000016414	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Vitronectin.	0.495