STRINGSTRING
PRKG1 PRKG1 GPAT4 GPAT4 TRAF3IP2 TRAF3IP2 ADA ADA F13B F13B HEG1 HEG1 ENSUMAP00000035005 ENSUMAP00000035005 WNK4 WNK4 STAT5A STAT5A GP6 GP6 HABP2 HABP2 ELOVL1 ELOVL1 F12 F12 ANO6 ANO6 BPIFA1 BPIFA1 FOXB1 FOXB1 ADRA2A ADRA2A TPH1 TPH1 RAB27A RAB27A STAT5B STAT5B HPS6 HPS6 WFS1 WFS1 CREB1 CREB1 CYP26B1 CYP26B1 UBASH3B UBASH3B CD34 CD34 AGR2 AGR2 HAS2 HAS2 AQP4 AQP4 SLC6A3 SLC6A3 ATP6V1B1 ATP6V1B1 ENSUMAP00000029735 ENSUMAP00000029735 F7 F7 F10 F10 APOH APOH GAS6 GAS6 EXT1 EXT1 HPS5 HPS5 ENSUMAP00000028297 ENSUMAP00000028297 PRKCD PRKCD SERPINC1 SERPINC1 ATG5 ATG5 PDSS2 PDSS2 FBLN1 FBLN1 TFPI2 TFPI2 EMILIN2 EMILIN2 ENSUMAP00000026814 ENSUMAP00000026814 UGCG UGCG BLOC1S6 BLOC1S6 TFPI TFPI F13A1 F13A1 ENSUMAP00000025302 ENSUMAP00000025302 LSR LSR SERPING1 SERPING1 ADTRP ADTRP EDN1 EDN1 SERPINE2 SERPINE2 PEAR1 PEAR1 DTNBP1 DTNBP1 TIFAB TIFAB MED1 MED1 F8 F8 ALOX12B ALOX12B MLLT6 MLLT6 FGG FGG FGA FGA ENSUMAP00000022362 ENSUMAP00000022362 FGB FGB CPB2 CPB2 ENSUMAP00000022061 ENSUMAP00000022061 ITGB3 ITGB3 AKAP11 AKAP11 XBP1 XBP1 CEL CEL NFE2L2 NFE2L2 PRSS56 PRSS56 LNPK LNPK EXT2 EXT2 ADAMTS18 ADAMTS18 SLC7A11 SLC7A11 ALOX12 ALOX12 CHRM1 CHRM1 PDGFB PDGFB F2 F2 ENSUMAP00000019674 ENSUMAP00000019674 THBS1 THBS1 NR1H3 NR1H3 C1QTNF1 C1QTNF1 MPIG6B MPIG6B FA2H FA2H VKORC1 VKORC1 GP1BA GP1BA NPR3 NPR3 SLC4A1 SLC4A1 TMPRSS11F TMPRSS11F HIF1A HIF1A STK39 STK39 KCNMA1 KCNMA1 CELSR2 CELSR2 GRHL3 GRHL3 PRKCE PRKCE ENSUMAP00000017592 ENSUMAP00000017592 STXBP3 STXBP3 PLAU PLAU CHRM3 CHRM3 CORO2A CORO2A STARD7 STARD7 KLKB1 KLKB1 F11 F11 ADRA2B ADRA2B PAPSS2 PAPSS2 P2RY12 P2RY12 TYRO3 TYRO3 TRPV5 TRPV5 SFN SFN KDF1 KDF1 PLG PLG CORO2B CORO2B LOC103660820 LOC103660820 GNA13 GNA13 ENSUMAP00000000459 ENSUMAP00000000459 HNF4A HNF4A ABCA12 ABCA12 STXBP1 STXBP1 VDR VDR SLC4A5 SLC4A5 LOC103667593 LOC103667593 FLG FLG FERMT3 FERMT3 PROS1 PROS1 CAV1 CAV1 AQP1 AQP1 TRPV4 TRPV4 GHRHR GHRHR ST3GAL4 ST3GAL4 PTPRO PTPRO ENSUMAP00000003507 ENSUMAP00000003507 CFTR CFTR SOCS2 SOCS2 PDGFRA PDGFRA SERPIND1 SERPIND1 CLDN1 CLDN1 EMP2 EMP2 ANXA5 ANXA5 TP63 TP63 PTPN6 PTPN6 KNG1 KNG1 HRG HRG MMRN1 MMRN1 TFAP2B TFAP2B F2RL1 F2RL1 PROCR PROCR PPP3CA PPP3CA ENPP4 ENPP4 NLRP6 NLRP6 PDGFA PDGFA FGF10 FGF10 AXL AXL AQP7 AQP7 AQP3 AQP3 TSPAN32 TSPAN32 ADCY6 ADCY6 VAMP8 VAMP8 PPBP PPBP LOC103665311 LOC103665311 IL18 IL18 DMTN DMTN F2RL2 F2RL2 ANO1 ANO1 SH2B3 SH2B3 P2RX1 P2RX1 SCNN1A SCNN1A CD9 CD9 VWF VWF TFAP2E TFAP2E GATA1 GATA1 AQP6 AQP6 CSN2 CSN2 LOC103673846 LOC103673846 SRF SRF COMP COMP MERTK MERTK HPSE HPSE F3 F3 NR1H2 NR1H2 KRT1 KRT1 SERPINF2 SERPINF2 SCNN1B SCNN1B SCNN1G SCNN1G OPRK1 OPRK1 PRL PRL PPIA PPIA INPP5K INPP5K PNPLA1 PNPLA1 ENSUMAP00000013924 ENSUMAP00000013924 CD40LG CD40LG ZNF385A ZNF385A F9 F9 FIBP FIBP BLOC1S4 BLOC1S4 ACER1 ACER1 ENSUMAP00000015139 ENSUMAP00000015139
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKG1cGMP-dependent protein kinase 1. (472 aa)
GPAT4Glycerol-3-phosphate acyltransferase 6 isoform X1. (456 aa)
TRAF3IP2TRAF3 interacting protein 2. (563 aa)
ADAAdenosine deaminase isoform X4. (423 aa)
F13BCoagulation factor XIII B chain. (627 aa)
HEG1LOW QUALITY PROTEIN: protein HEG homolog 1. (138 aa)
ENSUMAP00000035005annotation not available (128 aa)
WNK4Serine/threonine-protein kinase WNK4. (1215 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
GP6Platelet glycoprotein VI isoform X4. (278 aa)
HABP2Hyaluronan-binding protein 2. (561 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (296 aa)
F12Coagulation factor XII; Belongs to the peptidase S1 family. (517 aa)
ANO6Anoctamin. (807 aa)
BPIFA1BPI fold-containing family A member 1. (270 aa)
FOXB1Forkhead box protein B1. (255 aa)
ADRA2AAdrenoceptor alpha 2A. (418 aa)
TPH1Tryptophan 5-hydroxylase 1. (444 aa)
RAB27ARAB27A, member RAS oncogene family. (221 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
HPS6Hermansky-Pudlak syndrome 6 protein. (592 aa)
WFS1LOW QUALITY PROTEIN: wolframin. (853 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CYP26B1Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (304 aa)
UBASH3BUbiquitin-associated and SH3 domain-containing protein B. (630 aa)
CD34Hematopoietic progenitor cell antigen CD34. (227 aa)
AGR2Anterior gradient protein 2 homolog. (167 aa)
HAS2Hyaluronan synthase 2 isoform X1. (588 aa)
AQP4Aquaporin-4 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (301 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (509 aa)
ENSUMAP00000029735annotation not available (98 aa)
F7Coagulation factor VII. (414 aa)
F10Coagulation factor X. (499 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
GAS6LOW QUALITY PROTEIN: growth arrest-specific protein 6. (614 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (501 aa)
HPS5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (986 aa)
ENSUMAP00000028297annotation not available (137 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (725 aa)
SERPINC1antithrombin-III; Belongs to the serpin family. (465 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PDSS2Decaprenyl-diphosphate synthase subunit 2 isoform X1; Belongs to the FPP/GGPP synthase family. (400 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (751 aa)
TFPI2Tissue factor pathway inhibitor. (240 aa)
EMILIN2EMILIN-2. (1030 aa)
ENSUMAP00000026814annotation not available (119 aa)
UGCGCeramide glucosyltransferase. (392 aa)
BLOC1S6Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (172 aa)
TFPITissue factor pathway inhibitor. (333 aa)
F13A1Coagulation factor XIII A chain. (732 aa)
ENSUMAP00000025302annotation not available (209 aa)
LSRLipolysis-stimulated lipoprotein receptor. (598 aa)
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (481 aa)
ADTRPAndrogen-dependent TFPI-regulating protein. (246 aa)
EDN1Endothelin-1. (202 aa)
SERPINE2Glia-derived nexin; Belongs to the serpin family. (397 aa)
PEAR1LOW QUALITY PROTEIN: platelet endothelial aggregation receptor 1. (912 aa)
DTNBP1Dysbindin isoform X1. (305 aa)
TIFABTRAF-interacting protein with FHA domain-containing protein B. (201 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
F8Coagulation factor VIII isoform X2; Belongs to the multicopper oxidase family. (2337 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R-type. (687 aa)
MLLT6Protein AF-17. (1123 aa)
FGGFibrinogen gamma chain. (446 aa)
FGAFibrinogen alpha chain. (294 aa)
ENSUMAP00000022362annotation not available (212 aa)
FGBFibrinogen beta chain. (484 aa)
CPB2Carboxypeptidase B2. (361 aa)
ENSUMAP00000022061annotation not available (81 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (783 aa)
AKAP11A-kinase anchor protein 11. (1804 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (211 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (572 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X2. (590 aa)
PRSS56Serine protease 56; Belongs to the peptidase S1 family. (330 aa)
LNPKLunapark, ER junction formation factor. (429 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (718 aa)
ADAMTS18A disintegrin and metalloproteinase with thrombospondin motifs 18. (1156 aa)
SLC7A11Cystine/glutamate transporter isoform X2. (486 aa)
ALOX12LOW QUALITY PROTEIN: arachidonate 12-lipoxygenase, 12S-type. (604 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (418 aa)
PDGFBPlatelet-derived growth factor subunit B. (234 aa)
F2Prothrombin; Belongs to the peptidase S1 family. (569 aa)
ENSUMAP00000019674annotation not available (104 aa)
THBS1LOW QUALITY PROTEIN: thrombospondin-1. (1168 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
C1QTNF1Complement C1q tumor necrosis factor-related protein 1. (276 aa)
MPIG6BProtein G6b. (205 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
VKORC1Vitamin K Epoxide reductase complex subunit 1. (163 aa)
GP1BAPlatelet glycoprotein Ib alpha chain. (379 aa)
NPR3Atrial natriuretic peptide receptor 3. (492 aa)
SLC4A1Anion exchange protein. (924 aa)
TMPRSS11FTransmembrane protease serine; Belongs to the peptidase S1 family. (435 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
STK39STE20/SPS1-related proline-alanine-rich protein kinase. (502 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1. (1117 aa)
CELSR2Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2758 aa)
GRHL3Grainyhead-like protein 3 homolog isoform X1. (700 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (226 aa)
ENSUMAP00000017592annotation not available (120 aa)
STXBP3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (611 aa)
PLAUUrokinase-type plasminogen activator; Belongs to the peptidase S1 family. (432 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (552 aa)
CORO2ACoronin; Belongs to the WD repeat coronin family. (520 aa)
STARD7stAR-related lipid transfer protein 7, mitochondrial. (372 aa)
KLKB1Plasma kallikrein; Belongs to the peptidase S1 family. (653 aa)
F11LOW QUALITY PROTEIN: coagulation factor XI; Belongs to the peptidase S1 family. (604 aa)
ADRA2BLOW QUALITY PROTEIN: alpha-2B adrenergic receptor. (463 aa)
PAPSS2Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2. (629 aa)
P2RY12Purinergic receptor P2Y12. (329 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3. (845 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (258 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (812 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (623 aa)
LOC103660820Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (154 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (300 aa)
ENSUMAP00000000459annotation not available (218 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X2. (474 aa)
ABCA12ATP-binding cassette sub-family A member 12. (2594 aa)
STXBP1Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (580 aa)
VDRVitamin D3 receptor isoform X2. (427 aa)
SLC4A5Anion exchange protein. (1124 aa)
LOC103667593Filaggrin-2-like. (267 aa)
FLGFilaggrin. (1515 aa)
FERMT3LOW QUALITY PROTEIN: fermitin family homolog 3. (628 aa)
PROS1Vitamin K-dependent protein S. (631 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
TRPV4LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (837 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
ST3GAL4CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 4 isoform X2; Belongs to the glycosyltransferase 29 family. (390 aa)
PTPROReceptor-type tyrosine-protein phosphatase O. (1205 aa)
ENSUMAP00000003507annotation not available (155 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1475 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
SERPIND1Serpin family D member 1; Belongs to the serpin family. (527 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ANXA5Annexin. (321 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
KNG1Kininogen-1 isoform X1. (624 aa)
HRGHistidine-rich glycoprotein. (521 aa)
MMRN1Multimerin-1. (1227 aa)
TFAP2BTranscription factor AP-2-beta. (460 aa)
F2RL1Proteinase-activated receptor 2. (399 aa)
PROCREndothelial protein C receptor. (241 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
ENPP4Ectonucleotide pyrophosphatase/phosphodiesterase 4. (453 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (795 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (288 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
AXLTyrosine-protein kinase receptor UFO isoform X1. (887 aa)
AQP7Aquaporin-7 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (354 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (286 aa)
TSPAN32Tetraspanin-32; Belongs to the tetraspanin (TM4SF) family. (210 aa)
ADCY6Adenylate cyclase type 6. (919 aa)
VAMP8Vesicle-associated membrane protein 8. (108 aa)
PPBPC-X-C motif chemokine. (119 aa)
LOC103665311C-X-C motif chemokine. (106 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (217 aa)
DMTNDematin. (371 aa)
F2RL2Proteinase-activated receptor 3. (313 aa)
ANO1Anoctamin. (972 aa)
SH2B3SH2B adapter protein 3. (368 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
SCNN1AAmiloride-sensitive sodium channel subunit alpha; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (634 aa)
CD9Tetraspanin. (242 aa)
VWFVon Willebrand factor. (2721 aa)
TFAP2ETranscription factor AP-2-epsilon. (416 aa)
GATA1LOW QUALITY PROTEIN: erythroid transcription factor. (438 aa)
AQP6Aquaporin-6; Belongs to the MIP/aquaporin (TC 1.A.8) family. (160 aa)
CSN2Beta-casein. (218 aa)
LOC103673846Cytochrome b-245 light chain. (218 aa)
SRFSerum response factor. (446 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
MERTKTyrosine-protein kinase Mer. (975 aa)
HPSEHeparanase. (623 aa)
F3Tissue factor. (295 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (479 aa)
KRT1LOW QUALITY PROTEIN: keratin, type II cytoskeletal 1; Belongs to the intermediate filament family. (528 aa)
SERPINF2LOW QUALITY PROTEIN: alpha-2-antiplasmin; Belongs to the serpin family. (402 aa)
SCNN1BAmiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (641 aa)
SCNN1GLOW QUALITY PROTEIN: amiloride-sensitive sodium channel subunit gamma; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (599 aa)
OPRK1Kappa-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
PRLProlactin. (245 aa)
PPIAPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (170 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (455 aa)
PNPLA1Patatin-like phospholipase domain-containing protein 1 isoform X2. (565 aa)
ENSUMAP00000013924annotation not available (104 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
ZNF385AZinc finger protein 385A. (244 aa)
F9Coagulation factor IX. (460 aa)
FIBPAcidic fibroblast growth factor intracellular-binding protein. (357 aa)
BLOC1S4Biogenesis of lysosome-related organelles complex 1 subunit 4. (214 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (263 aa)
ENSUMAP00000015139annotation not available (194 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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