STRINGSTRING
DRD5 DRD5 NCSTN NCSTN RAPGEF3 RAPGEF3 BHLHB9 BHLHB9 NTF4 NTF4 ATP8A1 ATP8A1 ENSUMAP00000001610 ENSUMAP00000001610 CHMP2B CHMP2B CIC CIC ST3GAL4 ST3GAL4 GRIA1 GRIA1 KRAS KRAS PTPRZ1 PTPRZ1 GM2A GM2A CNTN2 CNTN2 GRIN2A GRIN2A LOC103656180 LOC103656180 BRINP1 BRINP1 SHROOM4 SHROOM4 NETO1 NETO1 CX3CR1 CX3CR1 DGCR2 DGCR2 NTRK2 NTRK2 PTCHD4 PTCHD4 LGMN LGMN ADGRF1 ADGRF1 RIC8A RIC8A STRA6 STRA6 NPTN NPTN MEF2C MEF2C BTG2 BTG2 PLCB1 PLCB1 TTBK1 TTBK1 TANC1 TANC1 LOC103671133 LOC103671133 LOC103671135 LOC103671135 HMGCR HMGCR CUX2 CUX2 PAK5 PAK5 SNAP25 SNAP25 NTF3 NTF3 B2M B2M CHST10 CHST10 CTNS CTNS LOC103673946 LOC103673946 ENSUMAP00000010865 ENSUMAP00000010865 SPG11 SPG11 SRF SRF CRTC1 CRTC1 NPTX2 NPTX2 DDHD2 DDHD2 NPS NPS PAFAH1B1 PAFAH1B1 BTBD9 BTBD9 ENSUMAP00000012742 ENSUMAP00000012742 LOC103674561 LOC103674561 HTT HTT JAKMIP3 JAKMIP3 JAKMIP2 JAKMIP2 AGER AGER PRRT1 PRRT1 KLK8 KLK8 AAAS AAAS ZNF385A ZNF385A GIT1 GIT1 CLN3 CLN3 ITGA5 ITGA5 NPAS4 NPAS4 PDE1B PDE1B NIPBL NIPBL PTCHD1 PTCHD1 NGF NGF PARK2 PARK2 ENSUMAP00000015922 ENSUMAP00000015922 PARK2-2 PARK2-2 IFT20 IFT20 TREM2 TREM2 TREML1 TREML1 ATAD1 ATAD1 SYNGAP1 SYNGAP1 PTEN PTEN ZZEF1 ZZEF1 PAK6 PAK6 METTL23 METTL23 CHD7 CHD7 HIF1A HIF1A TMPRSS11E TMPRSS11E UBA6 UBA6 CHRM1 CHRM1 APP APP CCND2 CCND2 SLC7A11 SLC7A11 BRAF BRAF NF1 NF1 ITGA3 ITGA3 GPR155 GPR155 CALB1 CALB1 GIP GIP PAIP2 PAIP2 ITGB1 ITGB1 LOC103669115 LOC103669115 PTN PTN ENSUMAP00000021992 ENSUMAP00000021992 CAMK4 CAMK4 TSC1 TSC1 CDK5 CDK5 MAPK8IP2 MAPK8IP2 MFSD2A MFSD2A TIFAB TIFAB PPP1R1B PPP1R1B TACO1 TACO1 VDAC1 VDAC1 NEDD9 NEDD9 SLC6A1 SLC6A1 PRKAR2B PRKAR2B SYT11 SYT11 ABL1 ABL1 ENSUMAP00000025822 ENSUMAP00000025822 GATM GATM RELN RELN SETD5 SETD5 SYNJ1 SYNJ1 SOBP SOBP TNR TNR TUSC3 TUSC3 MECP2 MECP2 SLC1A4 SLC1A4 NDRG4 NDRG4 LDLR LDLR NLGN3 NLGN3 EP300 EP300 ENSUMAP00000030862 ENSUMAP00000030862 DNAH11 DNAH11 ADCY8 ADCY8 ADCY3 ADCY3 CREB1 CREB1 RTL4 RTL4 NFATC4 NFATC4 JAKMIP1 JAKMIP1 CSMD1 CSMD1 KAT2A KAT2A ELAVL4 ELAVL4 CHRFAM7A CHRFAM7A DNAAF4 DNAAF4 SORCS3 SORCS3 C5AR1 C5AR1 SLC8A2 SLC8A2 FOXB1 FOXB1 CHL1 CHL1 GRM5 GRM5 VIP VIP RGS14 RGS14 B4GALT2 B4GALT2 S100B S100B LINS1 LINS1 SLC12A5 SLC12A5 CD164 CD164 POMK POMK GABRA5 GABRA5 CYFIP1 CYFIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DRD5D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (442 aa)
NCSTNNicastrin. (753 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (789 aa)
BHLHB9Protein BHLHb9. (550 aa)
NTF4LOW QUALITY PROTEIN: neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
ATP8A1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (978 aa)
ENSUMAP00000001610annotation not available (159 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
CICProtein capicua homolog. (2136 aa)
ST3GAL4CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 4 isoform X2; Belongs to the glycosyltransferase 29 family. (390 aa)
GRIA1Glutamate receptor 1 isoform X2. (907 aa)
KRASGTPase KRas isoform X3. (189 aa)
PTPRZ1Receptor-type tyrosine-protein phosphatase zeta. (2368 aa)
GM2AGanglioside GM2 activator-like. (195 aa)
CNTN2Contactin-2. (1008 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1412 aa)
LOC103656180LOW QUALITY PROTEIN: protein C10. (192 aa)
BRINP1BMP/retinoic acid-inducible neural-specific protein 1. (761 aa)
SHROOM4LOW QUALITY PROTEIN: protein Shroom4. (1453 aa)
NETO1Neuropilin and tolloid-like protein 1. (514 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
DGCR2Integral membrane protein DGCR2/IDD. (551 aa)
NTRK2BDNF/NT-3 growth factors receptor. (466 aa)
PTCHD4Patched domain-containing protein 4. (885 aa)
LGMNLegumain. (433 aa)
ADGRF1Probable G-protein coupled receptor 110; Belongs to the G-protein coupled receptor 2 family. (848 aa)
RIC8Asynembryn-A. (501 aa)
STRA6LOW QUALITY PROTEIN: stimulated by retinoic acid gene 6 protein homolog. (630 aa)
NPTNNeuroplastin. (367 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X3. (433 aa)
BTG2BTG anti-proliferation factor 2. (162 aa)
PLCB1Phosphoinositide phospholipase C. (1129 aa)
TTBK1Tau-tubulin kinase 1. (756 aa)
TANC1Protein TANC1. (1853 aa)
LOC103671133SH3 and multiple ankyrin repeat domains protein 1-like. (118 aa)
LOC103671135SH3 and multiple ankyrin repeat domains protein 2-like. (287 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
CUX2Homeobox protein cut-like. (1499 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (195 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
CHST10Carbohydrate sulfotransferase. (381 aa)
CTNSCystinosin, lysosomal cystine transporter. (404 aa)
LOC103673946LOW QUALITY PROTEIN: junctophilin-3-like. (107 aa)
ENSUMAP00000010865annotation not available (218 aa)
SPG11Spatacsin isoform X2. (2445 aa)
SRFSerum response factor. (446 aa)
CRTC1CREB-regulated transcription coactivator 1. (578 aa)
NPTX2Neuronal pentraxin-2. (291 aa)
DDHD2Phospholipase DDHD2. (731 aa)
NPSNeuropeptide S. (108 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
BTBD9BTB/POZ domain-containing protein 9 isoform X6. (391 aa)
ENSUMAP00000012742annotation not available (80 aa)
LOC103674561Adenylate cyclase type 1-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (328 aa)
HTTLOW QUALITY PROTEIN: huntingtin. (3048 aa)
JAKMIP3Janus kinase and microtubule-interacting protein 3. (763 aa)
JAKMIP2Janus kinase and microtubule-interacting protein 2. (815 aa)
AGERAdvanced glycosylation end product-specific receptor. (311 aa)
PRRT1LOW QUALITY PROTEIN: proline-rich transmembrane protein 1. (83 aa)
KLK8LOW QUALITY PROTEIN: kallikrein-8; Belongs to the peptidase S1 family. (139 aa)
AAASAladin WD repeat nucleoporin. (547 aa)
ZNF385AZinc finger protein 385A. (244 aa)
GIT1ARF GTPase-activating protein GIT1. (699 aa)
CLN3Battenin. (485 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1015 aa)
NPAS4Neuronal PAS domain-containing protein 4. (800 aa)
PDE1BPhosphodiesterase. (524 aa)
NIPBLNipped-B protein. (2805 aa)
PTCHD1Patched domain-containing protein 1. (803 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (356 aa)
PARK2E3 ubiquitin-protein ligase parkin isoform X5. (153 aa)
ENSUMAP00000015922annotation not available (110 aa)
PARK2-2E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (176 aa)
IFT20Intraflagellar transport protein 20 homolog. (132 aa)
TREM2Triggering receptor expressed on myeloid cells 2 isoform X2. (322 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (313 aa)
ATAD1ATPase family AAA domain-containing protein 1; Belongs to the AAA ATPase family. (361 aa)
SYNGAP1LOW QUALITY PROTEIN: ras/Rap GTPase-activating protein SynGAP. (1229 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
ZZEF1LOW QUALITY PROTEIN: zinc finger ZZ-type and EF-hand domain-containing protein 1. (2732 aa)
PAK6Non-specific serine/threonine protein kinase. (677 aa)
METTL23Methyltransferase-like protein 23. (190 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2976 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
TMPRSS11ETransmembrane protease serine 11E-like; Belongs to the peptidase S1 family. (419 aa)
UBA6Ubiquitin-like modifier-activating enzyme 6. (993 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (418 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (747 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (299 aa)
SLC7A11Cystine/glutamate transporter isoform X2. (486 aa)
BRAFSerine/threonine-protein kinase B-raf. (715 aa)
NF1Neurofibromin. (2862 aa)
ITGA3Integrin alpha-3; Belongs to the integrin alpha chain family. (1012 aa)
GPR155Integral membrane protein GPR155 isoform X1. (869 aa)
CALB1Calbindin 1. (261 aa)
GIPGastric inhibitory polypeptide. (176 aa)
PAIP2Polyadenylate-binding protein-interacting protein 2. (260 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
LOC103669115Diacylglycerol kinase. (770 aa)
PTNPleiotrophin. (210 aa)
ENSUMAP00000021992annotation not available (123 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (481 aa)
TSC1Hamartin. (1168 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (361 aa)
MAPK8IP2C-Jun-amino-terminal kinase-interacting protein 2. (559 aa)
MFSD2ASodium-dependent lysophosphatidylcholine symporter 1. (524 aa)
TIFABTRAF-interacting protein with FHA domain-containing protein B. (201 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (169 aa)
TACO1Translational activator of cytochrome c oxidase 1. (269 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
NEDD9Enhancer of filamentation 1. (842 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (222 aa)
SYT11Synaptotagmin-11. (404 aa)
ABL1Tyrosine-protein kinase. (1135 aa)
ENSUMAP00000025822annotation not available (158 aa)
GATMGlycine amidinotransferase, mitochondrial. (430 aa)
RELNLOW QUALITY PROTEIN: reelin. (3457 aa)
SETD5SET domain-containing protein 5 isoform X5. (1458 aa)
SYNJ1Synaptojanin-1 isoform X2. (1601 aa)
SOBPSine oculis-binding protein homolog. (577 aa)
TNRtenascin-R. (1349 aa)
TUSC3Tumor suppressor candidate 3. (291 aa)
MECP2methyl-CpG-binding protein 2. (172 aa)
SLC1A4Neutral amino acid transporter A. (427 aa)
NDRG4Protein NDRG4 isoform X1. (356 aa)
LDLRLow-density lipoprotein receptor. (927 aa)
NLGN3Neuroligin-3 isoform X1. (843 aa)
EP300LOW QUALITY PROTEIN: histone acetyltransferase p300. (2390 aa)
ENSUMAP00000030862annotation not available (66 aa)
DNAH11LOW QUALITY PROTEIN: dynein heavy chain 11, axonemal. (4485 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1163 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1274 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
RTL4Zinc finger CCHC domain-containing protein 16. (301 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (787 aa)
JAKMIP1Janus kinase and microtubule-interacting protein 1. (593 aa)
CSMD1CUB and sushi domain-containing protein 1. (3099 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (787 aa)
ELAVL4ELAV-like protein; Belongs to the RRM elav family. (402 aa)
CHRFAM7ACHRNA7-FAM7A fusion protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (540 aa)
DNAAF4Dyslexia susceptibility 1 candidate gene 1 protein isoform X1. (420 aa)
SORCS3VPS10 domain-containing receptor SorCS3. (1193 aa)
C5AR1LOW QUALITY PROTEIN: C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (331 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (197 aa)
FOXB1Forkhead box protein B1. (255 aa)
CHL1Neural cell adhesion molecule L1-like protein isoform X2. (1195 aa)
GRM5Glutamate metabotropic receptor 5. (959 aa)
VIPVasoactive intestinal peptide. (170 aa)
RGS14Regulator of G-protein signaling 14 isoform X4. (563 aa)
B4GALT2Beta-1,4-galactosyltransferase 2. (389 aa)
S100BProtein S100; Belongs to the S-100 family. (104 aa)
LINS1Protein Lines homolog isoform X1. (758 aa)
SLC12A5Solute carrier family 12 member 5. (1101 aa)
CD164Sialomucin core protein 24. (167 aa)
POMKProtein O-mannose kinase. (356 aa)
GABRA5Gamma-aminobutyric acid receptor subunit alpha-5 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (463 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1185 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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