(49 nodes) Regulation of release of sequestered calcium ion into cytosol network (Ursus maritimus)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	PTK2B	Protein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
	TRDN	Triadin. (285 aa)
	HRC	Sarcoplasmic reticulum histidine-rich calcium-binding protein. (704 aa)
	NPSR1	Neuropeptide S receptor isoform X1. (374 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
	PKD2	Polycystin-2. (831 aa)
	CAPN9	Calpain-9 isoform X1; Belongs to the peptidase C2 family. (669 aa)
	GPER1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	PRKD1	Serine/threonine-protein kinase D1. (874 aa)
	CD19	LOW QUALITY PROTEIN: B-lymphocyte antigen CD19. (555 aa)
	CXCL9	C-X-C motif chemokine 9 isoform X1. (153 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	CXCL11	C-X-C motif chemokine. (94 aa)
	LOC103673946	LOW QUALITY PROTEIN: junctophilin-3-like. (107 aa)
	LOC103673846	Cytochrome b-245 light chain. (218 aa)
	HTT	LOW QUALITY PROTEIN: huntingtin. (3048 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	CEMIP	Cell migration-inducing and hyaluronan-binding protein. (1358 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	CAPN3	Calpain-3 isoform X8; Belongs to the peptidase C2 family. (202 aa)
	CAPN3-2	Calpain-3 isoform X2; Belongs to the peptidase C2 family. (493 aa)
	ENSUMAP00000015030	annotation not available (82 aa)
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (411 aa)
	SEPN1	LOW QUALITY PROTEIN: selenoprotein N. (66 aa)
	ENSUMAP00000017592	annotation not available (120 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (226 aa)
	RYR2	Ryanodine receptor 2. (4923 aa)
	CALM2	Calmodulin 2. (149 aa)
	TRPC1	LOW QUALITY PROTEIN: short transient receptor potential channel 1; Belongs to the transient receptor (TC 1.A.4) family. (752 aa)
	CHD7	chromodomain-helicase-DNA-binding protein 7. (2976 aa)
	TMEM38B	Trimeric intracellular cation channel type B. (291 aa)
	F2	Prothrombin; Belongs to the peptidase S1 family. (569 aa)
	ENSUMAP00000022019	annotation not available (90 aa)
	ENSUMAP00000023188	annotation not available (93 aa)
	CLIC2	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (239 aa)
	DHRS7C	Dehydrogenase/reductase SDR family member 7C isoform X2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (311 aa)
	APLNR	Apelin receptor. (330 aa)
	ABL1	Tyrosine-protein kinase. (1135 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	LIME1	Lck-interacting transmembrane adapter 1. (277 aa)
	UBASH3B	Ubiquitin-associated and SH3 domain-containing protein B. (630 aa)
	FKBP1B	Peptidylprolyl isomerase. (79 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1 isoform X1. (572 aa)
	THY1	Thy-1 membrane glycoprotein. (161 aa)
	ENSUMAP00000032915	annotation not available (148 aa)
	DRD1	D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG5	HTT	ENSUMAP00000027625	ENSUMAP00000012947	Autophagy protein 5; Involved in autophagic vesicle formation.	LOW QUALITY PROTEIN: huntingtin.	0.425
CALM1	FKBP1B	ENSUMAP00000008358	ENSUMAP00000031652	Calmodulin 1; Belongs to the calmodulin family.	Peptidylprolyl isomerase.	0.861
CALM1	RYR2	ENSUMAP00000008358	ENSUMAP00000017715	Calmodulin 1; Belongs to the calmodulin family.	Ryanodine receptor 2.	0.973
CALM2	FKBP1B	ENSUMAP00000017876	ENSUMAP00000031652	Calmodulin 2.	Peptidylprolyl isomerase.	0.861
CALM2	RYR2	ENSUMAP00000017876	ENSUMAP00000017715	Calmodulin 2.	Ryanodine receptor 2.	0.747
CAPN3	CAPN3-2	ENSUMAP00000015012	ENSUMAP00000015025	Calpain-3 isoform X8; Belongs to the peptidase C2 family.	Calpain-3 isoform X2; Belongs to the peptidase C2 family.	0.899
CAPN3-2	CAPN3	ENSUMAP00000015025	ENSUMAP00000015012	Calpain-3 isoform X2; Belongs to the peptidase C2 family.	Calpain-3 isoform X8; Belongs to the peptidase C2 family.	0.899
CASQ1	CASQ2	ENSUMAP00000000713	ENSUMAP00000015637	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.901
CASQ1	RYR2	ENSUMAP00000000713	ENSUMAP00000017715	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 2.	0.935
CASQ1	TRDN	ENSUMAP00000000713	ENSUMAP00000001428	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Triadin.	0.548
CASQ2	CASQ1	ENSUMAP00000015637	ENSUMAP00000000713	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.901
CASQ2	FKBP1B	ENSUMAP00000015637	ENSUMAP00000031652	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Peptidylprolyl isomerase.	0.521
CASQ2	HRC	ENSUMAP00000015637	ENSUMAP00000001673	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Sarcoplasmic reticulum histidine-rich calcium-binding protein.	0.532
CASQ2	LOC103673946	ENSUMAP00000015637	ENSUMAP00000010600	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	LOW QUALITY PROTEIN: junctophilin-3-like.	0.535
CASQ2	PLN	ENSUMAP00000015637	ENSUMAP00000003472	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.587
CASQ2	RYR2	ENSUMAP00000015637	ENSUMAP00000017715	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 2.	0.993
CASQ2	TRDN	ENSUMAP00000015637	ENSUMAP00000001428	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Triadin.	0.946
CD19	CXCL10	ENSUMAP00000009893	ENSUMAP00000010170	LOW QUALITY PROTEIN: B-lymphocyte antigen CD19.	C-X-C motif chemokine.	0.519
CD19	CXCL9	ENSUMAP00000009893	ENSUMAP00000010163	LOW QUALITY PROTEIN: B-lymphocyte antigen CD19.	C-X-C motif chemokine 9 isoform X1.	0.447
CD19	LYN	ENSUMAP00000009893	ENSUMAP00000013226	LOW QUALITY PROTEIN: B-lymphocyte antigen CD19.	Tyrosine-protein kinase.	0.987