STRINGSTRING
WNT10A WNT10A HESX1 HESX1 LGR4 LGR4 FOXO3 FOXO3 FZD6 FZD6 WNT5A WNT5A FZD10 FZD10 EXT1 EXT1 AXIN1 AXIN1 FZD7 FZD7 SOSTDC1 SOSTDC1 PLPP3 PLPP3 FZD3 FZD3 JUP JUP SDC1 SDC1 PYGO1 PYGO1 SFRP1 SFRP1 FZD4 FZD4 TCF7L2 TCF7L2 GSK3B GSK3B STK4 STK4 EDNRA EDNRA WNT3 WNT3 WNT9B WNT9B WNT1 WNT1 WNT10B WNT10B TCF7L1 TCF7L1 ENSUMAP00000007957 ENSUMAP00000007957 DVL3 DVL3 FGF2 FGF2 CTNNB1 CTNNB1 WNT16 WNT16 WNT2 WNT2 LRP6 LRP6 CAV1 CAV1 LOC103682075 LOC103682075 SCYL2 SCYL2 EDA EDA CTDNEP1 CTDNEP1 DVL2 DVL2 FGF9 FGF9 LATS2 LATS2 CBY1 CBY1 LRP5 LRP5 WNT2B WNT2B WNT4 WNT4 PTEN PTEN SIAH2 SIAH2 GPC3 GPC3 WNT5B WNT5B RECK RECK SFRP4 SFRP4 BCL9 BCL9 YAP1 YAP1 DIXDC1 DIXDC1 CDH3 CDH3 WNT7A WNT7A FZD1 FZD1 RAB5A RAB5A EDN1 EDN1 TCF7 TCF7 RAPGEF1 RAPGEF1 FRZB FRZB RSPO3 RSPO3 BCL9L BCL9L WNT9A WNT9A WNT3A WNT3A LEF1 LEF1 STK3 STK3 WNT8A WNT8A SFRP2 SFRP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (270 aa)
HESX1Homeobox expressed in ES cells 1. (181 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (905 aa)
FOXO3Forkhead box protein O3. (453 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
WNT5AWingless-type MMTV integration site family, member 5. (123 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (398 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (501 aa)
AXIN1Axin-1 isoform X2. (867 aa)
FZD7LOW QUALITY PROTEIN: frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (541 aa)
SOSTDC1Sclerostin domain-containing protein 1. (206 aa)
PLPP3Lipid phosphate phosphohydrolase 3. (273 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
JUPJunction plakoglobin. (716 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (68 aa)
PYGO1LOW QUALITY PROTEIN: pygopus homolog 1. (380 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (534 aa)
TCF7L2Transcription factor 7-like 2. (587 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
STK4Serine/threonine-protein kinase 4. (496 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (175 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (334 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
TCF7L1Transcription factor 7-like 1. (535 aa)
ENSUMAP00000007957annotation not available (154 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (423 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
CTNNB1Catenin beta-1. (787 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
LRP6Low-density lipoprotein receptor-related protein 6 isoform X1. (1462 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
LOC103682075Segment polarity protein dishevelled homolog DVL-1-like. (893 aa)
SCYL2SCY1 like pseudokinase 2. (928 aa)
EDAectodysplasin-A; Belongs to the tumor necrosis factor family. (242 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (228 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (391 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LATS2Non-specific serine/threonine protein kinase. (1030 aa)
CBY1Chibby family member 1, beta catenin antagonist. (132 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1602 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (315 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (625 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (107 aa)
RECKReversion-inducing cysteine-rich protein with Kazal motifs. (926 aa)
SFRP4Secreted frizzled-related protein 4. (254 aa)
BCL9B-cell CLL/lymphoma 9 protein isoform X3. (1352 aa)
YAP1LOW QUALITY PROTEIN: yorkie homolog. (457 aa)
DIXDC1DIX domain containing 1. (472 aa)
CDH3Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. (790 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
EDN1Endothelin-1. (202 aa)
TCF7Transcription factor 7 isoform X4. (316 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1230 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
RSPO3R-spondin-3. (275 aa)
BCL9LLOW QUALITY PROTEIN: B-cell CLL/lymphoma 9-like protein. (1497 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X2. (450 aa)
STK3Serine/threonine-protein kinase 3. (497 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (326 aa)
SFRP2Secreted frizzled-related protein 2. (299 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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